Review of vascularized bone marrow transplantation: Current status and future clinical applications

Gordon, Robert D.; Tai, Chau; Suzuki, H.; Strande, Louise; Ramsamooj, Rajendra; Matthews, Martha S.; Black, Kirby S.; Hewitt, Charles W.

doi:10.1002/micr.20367

Cited by 25 publications

(13 citation statements)

References 50 publications

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“…These studies confirmed the superiority of VBMT for the hematopoietic reconstitution of donor bone marrow cells when compared with cellular bone marrow transplantations (BMT). [3][4][5][6][15][16][17][18][19][20][21][22][23] In their recent comprehensive review on VBMT, Gordon et al examined the newly found benefits, the unique characteristics and the applicability of VBMT as an alternative to BMT. They emphasized the importance of VBMT to potentially reduce the risk of engraftment failure, provide a more rapid engraftment, enhance cellular function, reduce graft-versus-host disease, and aid in inducing immunologic tolerance.…”

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confidence: 99%

“…They emphasized the importance of VBMT to potentially reduce the risk of engraftment failure, provide a more rapid engraftment, enhance cellular function, reduce graft-versus-host disease, and aid in inducing immunologic tolerance. 16 Different VBMT models were introduced in the literature, including marrow sources from the limb, sternum, femoral bone, and bilateral vascularized femoral bones. 3-6,16 -23 In addition, we have introduced different models of face allotransplantation in rats including a full-face, hemi-face and hemiface/calvaria model.…”

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confidence: 99%

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A New Composite Hemiface/Mandible/Tongue Transplantation Model in Rats

Külahçi

Siemionow²

2010

Annals of Plastic Surgery

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Extensive head and neck deformities, including bone and soft tissue defects, are always challenging for reconstructive surgeons. The purpose of this study was to extend the application of the face/scalp transplantation model in rats by the incorporation of vascularized mandible, masseter and tongue (based on the same vascular pedicle), and to use this as a model to test new reconstructive options for extensive head and neck deformities with involving large soft and bone tissue defects.A total of 10 composite hemiface/mandible/tongue transplantations were performed in Lewis rats (RT1). Hemimandibular bone, masseter muscle, tongue and hemifacial skin flaps were dissected based on the same vascular pedicle of common carotid artery and external jugular vein. The flaps were then transplanted to the recipient inguinal region. Evaluation methods included flap angiography, plain x-ray, computed tomographic scan, and histology.All transplants survived indefinitely and no graft loss was noted. Flap angiography demonstrated intact vascular supply to the bone. Computed tomography scan and bone histology confirmed the viability of the bone components for the composite grafts. Hematoxylin and eosin staining determined the presence of viable bone marrow cells within the transplanted mandible. Viability of the tongue was confirmed by the presence of pink color and bleeding after puncture, as well as by histology.We have introduced a new composite hemiface/mandible/tongue transplant model. The main advantage of this model is the presence of vascularized bone marrow within the mandibular component, which may facilitate future studies on chimerism and tolerance induction. Although this mandible composite allograft is placed heterotopically to the recipient inguinal region, we believe that it may serve as a new reconstructive option for the coverage of combined bone and soft tissue defects within the head and neck region.

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confidence: 99%

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confidence: 99%

A New Composite Hemiface/Mandible/Tongue Transplantation Model in Rats

Külahçi

Siemionow²

2010

Annals of Plastic Surgery

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“…This phenomenon has been demonstrated in several VBM transplant models in rats using limb, sternum, bone in vascularized continuity with the composite transplant, and alternate-recipient site femoral bone transplants. 17,[27][28][29] Additionally, graft-versus-host-disease (GVHD) has not developed following VBM transplantation, supporting the use of VBM contained in composite grafts as an immunomodulatory strategy. 9 The rat combined SIEA myocutaneous/vascularized femur transplant is a promising single-anastomosis model to explore the contributions of VBM to VCA survival, as the VBM component can be either included or excluded without major technical modifications.…”

Section: Discussionmentioning

confidence: 99%

Tunneled superficial inferior epigastric artery (SIEA) myocutaneous/vascularized femur chimeric flaps: A model to study the role of vascularized bone marrow in composite allografts

et al. 2011

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The role of vascularized bone marrow in promoting composite allograft survival can be assessed by intrinsically chimeric flaps. In this study, we introduce a significant modification to a previously described rat model of combined superficial inferior epigastric artery (SIEA) myocutaneous/vascularized femur transplantation. We previously noted autocannibalization in orthotopic myocutaneous SIEA allotransplants, which complicated clinical and histologic evaluation of rejection. We therefore designed syngeneic experiments in eight Lewis (RTl(1) ) rat pairs to explore the feasibility of tunneling the SIEA component of chimeric SIEA myocutaneous/vascularized femur flaps to the recipient dorsum. Vascularized SIEA myocutaneous/femur transplants survived in their entirety to POD 63 study endpoint with patent anastomoses in seven of eight (87.5%) transplants as confirmed clinically, histologically, and via near-infrared fluorescent angiography. Tunneling of the SIEA component of SIEA myocutaneous/vascularized femur flaps to the recipient dorsum can be achieved with high success rate and acceptable operative times, and is a technically easy method to study the role of vascularized bone marrow in composite allografts. This modification facilitates SIEA component monitoring, removes it from constant contact with cage bedding, and places it in a location where autocannibalization is unlikely.

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“…[15][16][17][18] For instance, abdominal wall transplants contain large skin/muscle components and accompany no underlying bone. In contrast, CTAs containing bone, such as osteocutaneous face and hand, may contain a tolerogenic advantage analogous to vascularized bone marrow transplantation, 19,20 which is present in osteocutaneous face and hand transplants.…”

Section: Immunologic Problemsmentioning

confidence: 97%

Concomitant Face and Hand Transplantation

Gordon¹,

Zor²,

Cetrulo³

et al. 2011

Annals of Plastic Surgery

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Face and hand composite tissue allotransplantations have evolved into a promising subset of reconstructive transplant surgery due to recent advances in immunotherapy. Concomitant composite tissue allotransplantation, which involves a variable combination of facial (myocutaneous versus osteomyocutaneous) and upper extremity (ie, various levels) composite subtypes, has been performed infrequently at this time. In this review, we will describe many reasons as to why this field remains unexplored. Undoubtedly, future investigation is warranted to investigate the potential advantages and disadvantages of using this approach versus a staged manner for alloreconstruction and to identify the complexities of cortical reorganization and rehabilitation in this setting.

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Review of vascularized bone marrow transplantation: Current status and future clinical applications

Cited by 25 publications

References 50 publications

A New Composite Hemiface/Mandible/Tongue Transplantation Model in Rats

A New Composite Hemiface/Mandible/Tongue Transplantation Model in Rats

Tunneled superficial inferior epigastric artery (SIEA) myocutaneous/vascularized femur chimeric flaps: A model to study the role of vascularized bone marrow in composite allografts

Concomitant Face and Hand Transplantation

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