Review of uterine fibroids: imaging of typical and atypical features, variants, and mimics with emphasis on workup and FIGO classification

Awiwi, Muhammad O.; Badawy, Mohamed; Shaaban, Akram M.; Menias, Christine O.; Horowitz, Jeanne M.; Soliman, Moataz; Jensen, Corey T.; Gaballah, Ayman H.; Ibarra-Rovira, Juan J.; Feldman, Myra K.; Wang, Mindy X.; Liu, Peter S.; Elsayes, Khaled M.

doi:10.1007/s00261-022-03545-x

Cited by 13 publications

(8 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Retrospective examination of the whole set of biochemical and radiological results can help us reach diagnostic insights. Typically, uterine leiomyomas present as well-defined masses demonstrating homogeneous density and intensity on CT and MRI, respectively [ 12 ]. On the other hand, uterine leiomyosarcomas tend to have ill-defined borders and a heterogeneous pattern [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Al-Ibraheem,

Abdulrahman,

Abdlkadir

et al. 2023

Cureus

View full text Add to dashboard Cite

Over the past decade, a series of rare and extraordinary uterine tumors have been discovered, with some featuring exceptionally uncommon tumor types. This highlights the growing recognition of these rare tumors due to evolutionary radiologic advancements. However, evaluating these patients requires adequate understanding to avoid misinterpretation and potential confusion with alternative differential diagnoses. This case is the first documented instance of two coexistent uterine benign tumors in a 45-year-old unmarried female patient. The patient's medical, gynecological, and surgical histories were unremarkable. Conventional abdominopelvic imaging via computed tomography (CT) and magnetic resonance imaging (MRI) revealed significant uterine expansion, indicating an atypical leiomyomatous or potentially leiomyosarcomatous mass. Subsequently, [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography (PET)/CT revealed hypermetabolic uterine enlargement, suggesting further evaluation. The patient underwent radical hysterectomy, and histopathological analysis revealed multiple uterine fibroids concurrently existing against the uterine angiomatosis. This case is the first documented instance of intricate pathological interplay within the uterus.

show abstract

Section: Discussionmentioning

confidence: 99%

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Al-Ibraheem,

Abdulrahman,

Abdlkadir

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…UL is diagnosed by pelvic exam, ultrasonography, and if necessary, contrast-enhanced magnetic resonance imaging (MRI) [ 6 ]. If the findings obtained from ultrasonography or contrast-enhanced MRI are not typical for UL or if the patient is experiencing rapid or postmenopausal mass enlargement, the rare malignant tumor uterine sarcoma, which also derives from uterine smooth muscle, should be added to the differential [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor

Hayashi

Sakai

Yaegashi

et al. 2023

CIMB

View full text Add to dashboard Cite

The benign tumor uterine leiomyoma (UL) develops from the smooth muscle tissue that constitutes the uterus, whereas malignant tumor uterine sarcoma develops from either the smooth muscle tissue or stroma and is different from UL and endometrial cancer. Uterine sarcoma is broadly classified into three types: uterine leiomyosarcoma, endometrial stromal sarcoma (ESS), and carcinosarcoma. Although uterine leiomyosarcoma and ESS are both classified as uterine sarcoma, they significantly differ in terms of their sites of occurrence, symptoms, and treatment methods. Uterine leiomyosarcoma develops from the muscle tissue constituting the wall of the uterus and accounts for approximately 70% of all uterine sarcoma cases. In contrast, ESS develops from the stromal tissue beneath the endometrium and accounts for approximately 25% of all uterine sarcoma cases. ESS is classified as either low grade (LG) or high grade (HG). This case report aimed to highlight the importance of histopathologic examinations based on surgical specimens. Herein, we reported the case of a 45-year-old woman suspected of having submucosal leiomyoma of the uterus based on imaging results. Transvaginal ultrasonography and endometrial biopsy or partial dilation and curettage were performed. Contrast-enhanced magnetic resonance imaging (MRI) revealed a 32-mm mass projecting from the posterior wall of the uterus into the uterine cavity. T2-weighted imaging revealed a low signal within the mass; thus, submucosal UL was suspected. Histopathologic examination of surgical specimens obtained from a patient suspected of having submucosal UL after contrast-enhanced MRI indicated that the patient had ESS. Despite the remarkable advancements in medical imaging technology, the accuracy of contrast-enhanced MRI for detecting uterine mesenchymal tumors is limited. Therefore, histopathologic diagnosis based on surgical specimens should be performed when medical grounds for diagnosing a benign tumor on contrast-enhanced MRI are lacking.

show abstract

“…Transvaginal US (TV-US) has greater sensitivity than transabdominal US in detecting uterine leiomyomas. However, in consideration of the advantages of magnetic resonance imaging (MRI), this imaging method can be used to precisely determine the number and localization of myomas and even perform volumetric calculations; thus, it is now regarded as the best imaging technique for the study of myomas [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Uterine Artery Embolization for the Treatment of Symptomatic Uterine Fibroids of Different Sizes: A Single Center Experience

Cappelli

Mosconi

Cocozza

et al. 2023

JPM

View full text Add to dashboard Cite

The present study aimed to evaluate the clinical and radiological 1-year outcomes of uterine artery embolization (UAE) performed in a selected population of women with symptomatic myomas and who do not wish to conceive. Between January 2004 and January 2018, a total of 62 patients with pre-menopausal status and with no wish to conceive in the future underwent UAE for the treatment of symptomatic fibroids. All the patients underwent magnetic resonance imaging (MRI) and/or transvaginal ultrasonography (TV-US) before and after the procedure at 1-year follow-up. Clinical and radiological parameters were recorded, stratifying the population into 3 groups according to the size of the dominant myoma (group 1: <50 mm; group 2: ≥50 and ≤80 mm; group 3: >80 mm). Mean fibroid diameter was significantly reduced (42.6% ± 21.6%) at 1-year follow-up, with excellent improvements in terms of both symptoms and quality of life. No significant difference was observed regarding baseline dimension and the number of myomas. No major complications were reported (2.5%). The present study confirms the safety and efficacy of UAE in the treatment of symptomatic fibroids in pre-menopausal women with no desire to conceive.

show abstract

Review of uterine fibroids: imaging of typical and atypical features, variants, and mimics with emphasis on workup and FIGO classification

Cited by 13 publications

References 97 publications

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Characteristic of Endometrial Stromal Sarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor

Uterine Artery Embolization for the Treatment of Symptomatic Uterine Fibroids of Different Sizes: A Single Center Experience

Contact Info

Product

Resources

About