Review of trends in essential oils as alternatives to antibiotics in bovine mastitis treatment

Tomanić, Dragana; Stanojević, Jovan; Galić, Ivan; Ružić, Zoran; Kukuric, Tijana; Tešin, Nadežda; Prpa, Blagoje; Kovačević, Zorana

doi:10.2298/zmspn2242047t

Cited by 5 publications

(5 citation statements)

References 54 publications

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“…Scientific data have reported the effectiveness of many plant-derived compounds in the treatment of mastitis, where essential oils (EOs) such as aromatic oily liquids obtained from plant materials are employed in phytotherapy for a long period of time [ 96 , 107 ]. Physiological and therapeutic benefits displayed by EOs along with GRAS (generally recognized as safe) status provide their wide range of application in veterinary medicine [ 108 ]. Due to antimicrobial and antibiofilm activities [ 109 ] EOs are being considered as a subject of interest to the scientific community in the development of novel therapeutic options.…”

Section: Alternative Strategies—potential Solutionsmentioning

confidence: 99%

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

2023

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Despite preventive and therapeutic measures, mastitis continues to be the most prevalent health problem in dairy herds. Considering the risks associated with antibiotic therapy, such as compromised effectiveness due to the emergence of resistant bacteria, food safety issues, and environmental impact, an increasing number of scientific studies have referred to the new therapeutic procedures that could serve as alternatives to conventional therapy. Therefore, the aim of this review was to provide insight into the currently available literature data in the investigation of non-antibiotic alternative approaches. In general, a vast number of in vitro and in vivo available data offer the comprehension of novel, effective, and safe agents with the potential to reduce the current use of antibiotics and increase animal productivity and environmental protection. Constant progress in this field could overcome treatment difficulties associated with bovine mastitis and considerable global pressure being applied on reducing antimicrobial therapy in animals.

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Section: Alternative Strategies—potential Solutionsmentioning

confidence: 99%

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

2023

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“…In addition to different types of EOs, the pharmaceutical formulations and the dosage regimens used are diverse. Essential oils can be applied intramammarily or topically by the application of semisolid pharmaceutical formulations (gel or ointment) [131].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update

et al. 2023

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Bovine mastitis is a major concern for the dairy cattle community worldwide. Mastitis, subclinical or clinical, can be caused by contagious or environmental pathogens. Costs related to mastitis include direct and indirect losses, leading to global annual losses of USD 35 billion. The primary treatment of mastitis is represented by antibiotics, even if that results in the presence of residues in milk. The overuse and misuse of antibiotics in livestock is contributing to the development of antimicrobial resistance (AMR), resulting in a limited resolution of mastitis treatments, as well as a serious threat for public health. Novel alternatives, like the use of plant essential oils (EOs), are needed to replace antibiotic therapy when facing multidrug-resistant bacteria. This review aims to provide an updated overview of the in vitro and in vivo studies available on EOs and their main components as an antibacterial treatment against a variety of mastitis causing pathogens. There are many in vitro studies, but only several in vivo. Given the promising results of treatments with EOs, further clinical trials are needed.

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“…Essential oils (EO) could be an interesting natural alternative to prevent teat infections and to limit antibiotic use in mastitis treatment [15]. In addition, EOs are generally considered safe, and unlike antibiotics, bacteria do not appear to develop resistance to them, even during prolonged use [16,17]. As current treatment options become increasingly ineffective against resistant bacteria, the development of alternative phytotherapy products can combat antimicrobial resistance and provide sustainable animal health solutions that ensure safe and high-quality food production [18].…”

Section: Introductionmentioning

confidence: 99%

Clinical Evidence on Expansion of Essential Oil-Based Formulation’s Pharmacological Activity in Bovine Mastitis Treatment: Antifungal Potential as Added Value

Tomanić,

Božić,

Kladar

et al. 2024

Antibiotics

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Bovine mastitis, as a significant and prevalent health problem in dairy herds, is primarily attributed to bacterial infections. Yeasts, although considered relatively rare causative agents, have also been associated with mastitis in dairy cattle. Current mastitis treatment predominantly relies on antibiotics, with limited emphasis on antifungal treatment. However, mycotic mastitis is challenging to treat, since these fungi are often resistant to antibiotics and may even utilize them for energy. In the current research, the in vivo antimicrobial activity of the essential oil-based formulation (Phyto-Bomat), as a possible alternative mastitis treatment associated with yeasts, was studied. This study involved a total of 68 animals from two dairy farms with diagnosed mastitis, and three treatment groups were established: conventional antibiotic treatment, Phyto-Bomat treatment, and the combination of both. The findings suggest significant variations in the presence of Candida samples based on the treatment administered, and the most significant difference was noted in cows treated with the combination (Phyto-Bomat and antibiotics). Yet, it is important to note that the results reveal that, regardless of the treatment type, there are statistically significant differences in the presence of Candida samples across the examined time points. These results aim to provide valuable insights into the potential of EOs as an alternative therapy in bovine mastitis, specifically targeting yeasts. Such findings could offer new strategies in the mycotic mastitis control and reducing the occurrence of secondary infections following antibiotic treatment.

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Review of trends in essential oils as alternatives to antibiotics in bovine mastitis treatment

Cited by 5 publications

References 54 publications

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

Plant Essential Oils as a Tool in the Control of Bovine Mastitis: An Update

Clinical Evidence on Expansion of Essential Oil-Based Formulation’s Pharmacological Activity in Bovine Mastitis Treatment: Antifungal Potential as Added Value

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