Review of the Treatment of Periocular Infantile Hemangiomas With Beta Blockers

Tamez, Heather

doi:10.1097/iio.0000000000000147

Cited by 3 publications

(2 citation statements)

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“…2 IH in the periocular region deserves special attention as it causes life-long vision-threatening complications. 11 Many IH in the periocular region are small and do not require treatment, although direct compression caused by a deep component of the lesion or secondary to induced ptosis may reshape the globe, resulting in unequal refractive power between the eyes. Periocular IH should be diagnosed early and treated promptly because of its serious complications due to their specific location.…”

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Excellent Response of Infantile Hemangioma with Oral Propranolol: A Case Report

Denissafitri

Pramitha

Widia

et al. 2022

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Background: Infantile hemangioma (IH) is the most common benign tumor in infancy. Most IHs resolve spontaneously and do not require treatment. Therapeutic intervention is necessary for life-threatening IH, tumors posing functional risks, ulceration, and severe anatomic distortion, especially on the face. Beta-blockers, most specifically propranolol, have been shown to induce involution of IH, which should be administered as early as possible to avoid potential complications. Purpose: To report a case of IH with visual impairment treated successfully using oral propranolol. Case: A 4-month-old girl weighing, 6.3 kg, with redness plaques on the right face since 3 weeks after birth. The lesions rapidly increased in size within 2 months, and the lesions on her right eyelid made it difficult to open her right eye. Dermatological examination showed erythematous plaques, compressible and varying in size and ptosis. The patient was diagnosed with periocular infantile hemangioma and was given oral propranolol therapy with an initiated dose 3x1 mg. The dose was increased gradually. The lesions were significantly decreased and she could open her right eye normally after 5 months of propranolol therapy. Discussion: Some cases of IH require early treatment. Early treatment is indicated for IH causing functional impairment. The use of propranolol in the management of IH is very effective in the reduction of the lesions and Has minimal side effects. Conclusion: Early diagnosis and intervention with propranolol for IH play an important role in determining the optimal outcomes.

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confidence: 99%

Excellent Response of Infantile Hemangioma with Oral Propranolol: A Case Report

Denissafitri

Pramitha

Widia

et al. 2022

BIKK

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“…O tratamento com propranolol sistêmico é recomendado nas lesões que causam risco de ambliopia, na fase proliferativa, sendo capaz de reduzir as alterações anatômicas e funcionais (alterações de refração) (Snir et al, 2011;Spiteri Cornish;Reddy, 2011). A melhor resposta na fase proliferativa da lesão pode estar ligada a um diferente perfil de expressão de receptores beta-adrenérgico em cada estágio da lesão (Tamez;Sobel 2017). A presença de receptores adrenérgicos em distintas fases clínicas do hemangioma infantil foi investigada empregando diferentes metodologias (Chisholm et al, 2012;Boucek et al, 2013;Phillips et al, 2017).…”

Section: Prognóstico Visualunclassified

Avaliação in vivo da segurança de tartarato de metoprolol intravítreo em olhos com hemangioma circunscrito de coroide. Estudo fase I

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Agradeço às pessoas às quais dedico toda a minha vida, pois são a razão dela existir: meus pais, Ronaldo e Shirley. Muito obrigado pelo amor infinito, apoio e investimento constante nos meus estudos. Por terem me dado todas as ferramentas para que eu alcançasse meus sonhos, mesmo abdicando dos seus. Aos meus irmãosLuciano e Ângelo, à Danielle, ao Lucas e aos meus amigos próximos, pelo amor, companheirismo e apoio incondicional. Por estarem presentes e serem meu porto seguro. A todos os mestres e amigos da UFJF que me proporcionaram fundações sólidas. Em especial ao Prof. Dr. Leonardo Provetti Cunha, por despertar meu interesse pela Oftalmologia.

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