Review of the reproductive biology of amphipods and their endocrine regulation: Identification of mechanistic pathways for reproductive toxicants

Hyne, Ross V.

doi:10.1002/etc.673

Cited by 68 publications

(76 citation statements)

References 135 publications

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“…Indeed, it was established that the molt cycle of M. rosenbergii lasts an average of 15 days (Ross, 2001). Moreover, several studies have highlighted the variation of the 20-HE concentration during the different stages of the molt cycle of crustaceans (Hyne, 2011;Okumura and Aida, 2000;Zou and Bonvillain, 2004;Zou, 2005). The variation of 20-HE concentration observed here could be due to variations of ecdysteroid synthesis according to the developmental stage of prawns.…”

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 52%

“…The 20-HE decrease observed here could also be explained by a modification of the excretion rate of the hormone or an inactivation of the enzyme involved in the ecdysteroid biotransformation. Because of the fact that CLD impacts the 20-HE concentration, it could therefore in the long-term disturb the molting of organisms which is induced by this hormone (Hyne, 2011;Rodríguez et al, 2007). This hypothesis is supported by the studies of Hirano et al (2009) which have shown that low 20-HE concentration in the shrimp Americamysis bahia exposed to nonylphenol (also known to be an inhibitor of ecdysteroid activity) affected the growth of organisms.…”

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 89%

“…Thus, it could be hypothesized that CLD decreased the 20-HE concentration by binding directly to ecdysteroid receptor, as a consequence of its anti-ecdysteroidal activity (Zou and Fingerman, 1999d;Zou, 2005). However, as other EDCs, CLD can also interfere the endocrine system indirectly by several mechanisms, at any step of the transduction pathway of the hormones (Hyne, 2011;Rodríguez et al, 2007). The 20-HE decrease observed here could also be explained by a modification of the excretion rate of the hormone or an inactivation of the enzyme involved in the ecdysteroid biotransformation.…”

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 99%

“…Snyder and Mulder (2001) have also suggested that the delay in the beginning of molting of larvae in the lobster H. americanus when exposed to heptachlor, probably correlated to a drop in the concentrations of circulating ecdysteroids. Moreover, knowing that crustacean reproduction is linked to the molt cycle (Hyne, 2011), disruption in the molting process could also cause disturbances in reproduction as hypothesized by Gismondi and Thomé (2014) in the amphipod, G. pulex. Indeed, it was observed that the anti-ecdysteroidal activity of nonylphenol caused a reduction in fecundity of many insects (LeBlanc et al, 2000).…”

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 99%

“…Indeed, as explained above, a decrease of the 20-HE concentration was observed after 15 days of exposure. 20-HE is known to induce the molt cycle, which involves the chitobiase enzyme to break down the old cuticle (Hyne, 2011). Nevertheless, no information is available on the duration of the molt cycle and the different pathway cascades in M. rosenbergii (i.e.…”

Section: Chlordecone Effects On Chitobiase Activitymentioning

confidence: 99%

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Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii

et al. 2016

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a b s t r a c tChlordecone (CLD) is an organochlorine insecticide abundant in aquatic environment of the French West Indies. However, few studies have investigated its impact on freshwater invertebrates. Whereas CLD is suspected of inducing endocrine disruption, this work aimed to study the effects of environmentally relevant concentrations of CLD on the 20-hydroxyecdysone (20-HE) hormone concentration and on the chitobiase activity, both having key roles in the molting process of crustaceans. In addition, the bioaccumulation of CLD was measured in the muscle tissue of Macrobrachium rosenbergii to underline potential dose-response relationship. The results have shown that CLD was bioaccumulated in exposed organisms according to a trend to a dose-response relationship. Moreover, it was observed that CLD decreased the 20-HE concentration in exposed prawns when compared to control, whatever the duration of exposure, as well as it inhibited the chitobiase activity after 30 days of exposure. The present study indicates that CLD could interfere with molting process of M. rosenbergii by disturbing the 20-HE concentration and the activity of chitobiase, suggesting consequences at the long term on the shrimp development. This study also confirmed that CLD could be an endocrine disruptor in decapod crustaceans, as it was already observed in vertebrates.

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Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 52%

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 89%

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 99%

Section: Chlordecone Effects On the 20-he Concentrationmentioning

confidence: 99%

Section: Chlordecone Effects On Chitobiase Activitymentioning

confidence: 99%

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Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii

et al. 2016

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In Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 1—Gauging the Confounding Influence of Temperature and Water Hardness

Chaumot

Coulaud

Adam

et al. 2020

Enviro Toxic and Chemistry

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Monitoring the adverse effects of environmental contaminants on the reproduction of invertebrate species in the field remains a challenge in aquatic ecotoxicology. To meet the need for reliable tools for in situ toxicity assessment, we present the first part of a methodological study of the in situ implementation of a reproductive bioassay in Gammarus previously developed for screening the toxicity of chemical compounds during laboratory exposure. To ensure the correct interpretation of the modulation of reproductive markers (molting, fecundity, follicle growth, and embryonic development) in uncontrolled environmental conditions, we experimentally assessed and statistically modeled the variability in the female reproductive cycle during laboratory exposure under several temperature and water hardness conditions. Whereas water hardness did not influence the reproductive cycle, the significant accelerating effect of temperature on the dynamics of molting and marsupial development was finely modeled, by detailing the influence of temperature on the probability of transition between all molt and embryonic stages along the female cycle. In addition, no effect of temperature or water hardness was detected on the number of oocytes and embryos carried by females. Furthermore, the finding that the relative durations of the first 4 molt and embryonic stages are constant whatever the temperature makes it possible to predict the molting dynamics in fluctuating temperature conditions. Because this could allow us to take into account the confounding influence of temperature on the measurement of reproductive markers, the implications of these findings for an optimal in situ implementation of the reproductive bioassay with G. fossarum are discussed. The relevance of this modeling approach during in situ implementation is tested in a companion study. Environ Toxicol Chem 2020;39:667–677. © 2019 SETAC

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Optimizing Sex Ratios of Hyalella azteca to Reduce Variability in Reproduction and Improve Reproductive Toxicity Test Methods

Khan,

Bartlett,

Kudla

et al. 2023

Enviro Toxic and Chemistry

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Standard toxicological test methods with Hyalella azteca incorporate both lethal and sublethal (growth, reproduction) endpoints, though lethal endpoints are often favoured in routine testing. However, sublethal endpoints are important to consider as they are ecologically relevant and are often more sensitive than lethality. It is difficult to achieve robust data for reproduction in H. azteca because a high biological variability associated with reproductive yield, likely due to complex interactions in mate selection which can add to the variability in brood sizes that female produce. In addition, effects on reproduction often co‐occur with effects on growth, making it difficult to differentiate effects of growth from those on reproduction in standard tests initiated with juveniles. This study characterized the reproductive capacity of H. azteca by investigating the role of sex ratios in reproductive yield. Experiments were initiated in the absence of toxicants with sexually mature (6‐8‐week‐old) individuals that were placed in different female to male ratios (1:1, 2:3, 3:2 and 7:3). Reproduction was monitored during weekly static renewals for seven weeks. Results indicated that a higher female:male ratio (7 females to 3 males) improved reproductive success and lowered biological variability in reproduction. In addition, the body lengths and weights of newly mature amphipods were used to create a size distribution to aid in the identification of small female amphipods. Based on the results of this study, a novel reproductive toxicity test method is proposed that begins with sexually mature amphipods in a ratio of seven females to three males to minimize reproductive variability in amphipods and to enable a more effective assessment of contaminants using reproduction as a highly sensitive endpoint.

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Review of the reproductive biology of amphipods and their endocrine regulation: Identification of mechanistic pathways for reproductive toxicants

Cited by 68 publications

References 135 publications

Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii

Effects of chlordecone on 20-hydroxyecdysone concentration and chitobiase activity in a decapod crustacean, Macrobrachium rosenbergii

In Situ Reproductive Bioassay with Caged Gammarus fossarum (Crustacea): Part 1—Gauging the Confounding Influence of Temperature and Water Hardness

Optimizing Sex Ratios of Hyalella azteca to Reduce Variability in Reproduction and Improve Reproductive Toxicity Test Methods

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