Review of the mutagenicity/genotoxicity of butylated hydroxytoluene

Bomhard, E.; Bremmer, Jan Ν.; Herbold, B.

doi:10.1016/0165-1110(92)90043-9

Cited by 29 publications

(15 citation statements)

References 60 publications

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“…As reported in Bomhard et al [6] , with regard to point mutation assays, negative results were obtained in most of the genotoxicity tests with BHT. These tests include in vitro studies performed with various bacterial species, strains and various mammalian cell lines as well as in vivo studies with Drosophila melanogaster, silk worms and mouse specific locus tests [6,18] .…”

Section: Discussionmentioning

confidence: 77%

“…As reported in Bomhard et al [6] study, there were a large number of genotoxicity studies done with BHT in Salmonella typhimurium in the 1980's and 1990's. The study conducted by Shelef and Chin , indicated that the addition of BHT (5-20 µg/plate) caused a 2-fold increase on mutagenic potential of aflatoxin B1 using Salmonella typhimurium TA98 and TA100 strains [20] .…”

Section: Discussionmentioning

confidence: 97%

“…These tests include in vitro studies performed with various bacterial species, strains and various mammalian cell lines as well as in vivo studies with Drosophila melanogaster, silk worms and mouse specific locus tests [6,18] . According to the European Food Safety Authority Panel (EFSA Panel), effects of BHT on tumor formation reported by Olsen et al are subject to a threshold because the genotoxicity studies generally show a lack of potential for BHT to induce point mutations, chromosomal aberrations, or to interact with or damage DNA [18,19] .…”

Section: Discussionmentioning

confidence: 99%

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Bütil Hidroksitoluen Tarafından Mikronükleus İndüksiyonunun Wistar Sıçan Kemik İliği Hücrelerinde Araştırılması

Polat¹,

Bingöl²,

Turaçlar³

2014

Kafkas Univ Vet Fak Derg

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SummaryThis study aims to investigate whether Butylated Hydroxytoluene (BHT), the synthetic antioxidant and food additive, increases the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in rat bone marrow. BHT, dissolved in corn oil, was administered intraperitoneally to 8-10 week old male and female Wistar rats (n=36) in three different doses (125, 250 and 500 mg/kg b.w.) for two different time periods. 12-and 24-h after BHT treatment, the bone marrow samples were analyzed for the frequency of MNPCEs. Additionally, by evaluating the ratio of polychromatic erythrocyte to normochromatic erythrocyte (PCE/NCE), the cytotoxic effect of BHT on bone marrow was tested. It was found that all BHT doses at two time periods significantly increased the MNPCEs frequency about 1.9-2.84 fold. On the other hand, BHT caused significant decreased in the PCE/NCE ratio, which is indicative of bone marrow cytotoxicity when compared to the control groups. This study showed that BHT increased the formation of MNPCEs in rat bone marrow and we think that this increase might be related to the applied doses and the administration way BHT. Keywords: Butylated hydroxytoluene, Cytotoxicity, Genotoxicity, Micronucleus Bütil Hidroksitoluen Tarafından Mikronükleus İndüksiyonunun Wistar Sıçan Kemik İliği Hücrelerinde Araştırılması ÖzetBu çalışma ile sentetik antioksidan ve yiyeceklerde katkı maddesi olarak kullanılan Bütil Hidroksitoluenin (BHT) rat kemik iliğinde mikronükleuslu polikromatik eritrositlerin sayılarında herhangi bir artışa neden olup olmadığı araştırıldı. Mısır yağında çözülen BHT, iki farklı zaman periyodu ve üç farklı dozda (125, 250, 500 mg/kg v.a.), 8-10 haftalık erkek ve dişi Wistar albino sıçanlara (n=36) intraperitonal olarak verildi. BHT muamelesinden 12 ve 24 saat sonra kemik iliği örnekleri MNPCE sayısı için analiz edildi. Ayrıca, polikromatik eritrositlerin normokromatik eritrositlere oranı (PCE/NCE) değerlendirilerek BHT'nin kemik iliğindeki sitotoksik etkisine bakıldı. Bütün BHT dozları ve iki farklı zaman periyodunda MNPCE'lerin sayısında 1.9-2.84 kat önemli artışlar bulundu. Diğer taraftan BHT, kemik iliği sitotoksisite belirteci olan PCE/NCE oranını kontrol grubuna kıyasla düşürdü. Sonuç olarak bu çalışmada BHT'nin rat kemik iliğinde MNPCE oluşumunu artırdığını ve bu artışın, uygulanan dozlar ve verilme şekliyle ilişkili olabileceğini düşünmekteyiz.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Bütil Hidroksitoluen Tarafından Mikronükleus İndüksiyonunun Wistar Sıçan Kemik İliği Hücrelerinde Araştırılması

Polat¹,

Bingöl²,

Turaçlar³

2014

Kafkas Univ Vet Fak Derg

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“…Auch diese Untersuchung lässt eher auf einen unspezifischen Effekt schließen. Massive Zytotoxizität, die jedoch nicht quantifiziert wurde, wurde auch in der Untersuchung von Patterson et al (1987) (Bomhard et al 1992). …”

Section: Chromosomenaberrationstestsunclassified

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 39. Lieferung, Ausgabe 2004 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkungen auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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“…BHT alone is believed to have little mutagenic and clastogenic potential, and has ability to suppress tumorigenic, carcinogenic and clastogenic damage induced by various chemical compounds [34][35][36][37]. For example, BHT was reported to suppress aflatoxin B1-induced hepato carcinoma formation in male rats [38].…”

Section: Bhtmentioning

confidence: 99%

Disruption of Vitamin E and Butylated Hydroxytoluene Antioxidant Function in Response to Paraquat-Induced Chromosomal Damage in Cultured Anuran Leukocytes

Hanada¹

2014

Biol Med (Aligarh)

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Researchers have reported that the phenolic antioxidants vitamin E and butylated hydroxyltoluene (BHT) effect on cultured cells and human low-density lipoprotein is disrupted by various synthetic chemical compounds and Cu 2+ involved in reactive oxygen species (ROS) generation by redox reaction. In this paper, information involved in prooxidative action of vitamin E and BHT in cultured anuran leukocytes is provided in attempt to clarify such disruption mechanisms of antioxidant function.

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Review of the mutagenicity/genotoxicity of butylated hydroxytoluene

Cited by 29 publications

References 60 publications

Bütil Hidroksitoluen Tarafından Mikronükleus İndüksiyonunun Wistar Sıçan Kemik İliği Hücrelerinde Araştırılması

Bütil Hidroksitoluen Tarafından Mikronükleus İndüksiyonunun Wistar Sıçan Kemik İliği Hücrelerinde Araştırılması

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

Disruption of Vitamin E and Butylated Hydroxytoluene Antioxidant Function in Response to Paraquat-Induced Chromosomal Damage in Cultured Anuran Leukocytes

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