Review of the macrophage disappearance reaction

Mw, Barth; Hendrzak, Jill A.; Melnicoff, Meryle J.; Morahan, Page S.

doi:10.1002/jlb.57.3.361

Cited by 156 publications

(134 citation statements)

References 34 publications

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“…One hour after infection, the number of leukocytes collected by peritoneal lavage decreased in both Onzin Ϫ/Ϫ mice and controls, despite the initiation of neutrophil recruitment to the site of infection. This initial decrease in the number of leukocytes collected by peritoneal lavage after induction of peritonitis has been noted previously and is likely due to macrophage activation and adhesion of the cells to membranes within the peritoneal cavity (38,39). However, consistent with the elevated serum proteins recovered in the lavage fluid, the total leukocyte counts of the Onzin Ϫ/Ϫ mice are significantly higher than that of the control animals.…”

Section: Enhanced Response Of Onzinsupporting

confidence: 75%

Impaired Host Defense in Mice Lacking ONZIN

Ledford

Kovářová

Koller

2007

The Journal of Immunology

101

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ONZIN is a small, cysteine-rich peptide of unique structure that is conserved in all vertebrates examined to date. We show that ONZIN is expressed at high levels in epithelial cells of the intestinal tract, the lung, and in cells of the immune system including macrophages and granulocytes. Because this pattern of expression is suggestive of a role in innate immune function, we have generated mice lacking this protein and examined their ability to respond to challenge with infectious agents. Onzin−/− mice show a heightened innate immune response after induction of acute peritonitis with Klebsiella pneumoniae. This increased response is consistent with an increased bacterial burden in the Onzin−/− mice. Ex vivo studies show that, whereas phagocytosis is not altered in Onzin−/− neutrophils, phagocytes lacking this protein kill bacteria less effectively. This result identifies ONZIN as a novel class of intracellular protein required for optimal function of the neutrophils after uptake of bacteria.

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Section: Enhanced Response Of Onzinsupporting

confidence: 75%

Impaired Host Defense in Mice Lacking ONZIN

Ledford

Kovářová

Koller

2007

The Journal of Immunology

101

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“…Within 1 h infection all macrophages disappear from the peritoneal wash (22). The function of this "macrophage disappearance reaction" is not understood, although it is likely that these peritoneal wash cells act as a strategic reserve that is mobilized on infection.…”

Section: Discussionmentioning

confidence: 99%

IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection

Nguyen

Tran

Müller

et al. 2012

The Journal of Immunology

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The peritoneal wash of BALB/c or C57BL/6 mice contains two populations of macrophages that differ in their level of expression of MHC class II (MHC II). Although both populations efficiently phagocytose bacteria in vivo, only the MHC IIlo population is effective at phagocytosing apoptotic cells in vivo and only the MHC IIhi population is effective at presenting Ag to T cells in vitro. Soon after induction of a peritoneal infection both of these macrophage populations are lost from the peritoneal wash fraction. Blood monocytes then enter the inflamed peritoneum and develop into new peritoneal macrophages. Whether these monocytes develop into MHC IIlo or into MHC IIhi macrophages is crucially dependent on the cytokine IL-10, which is transiently elevated in the peritoneal wash during the early phase of infection. Monocytes from CD45.1 animals transferred early in infection when the IL-10 concentration is high into congenic CD45.2 recipients develop into the MHC IIlo macrophage population. Monocytes transferred later, when the IL-10 concentration has fallen, develop into the MHC IIhi population. In infected IL-10–deficient animals monocytes fail to develop into the MHC IIlo population but can be induced to do so by exogenous application of IL-10. Finally, high numbers of wild-type monocytes injected into IL-10R1–deficient animals develop into MHC IIlo macrophages and were able by a bystander effect to induce the differentiation of the endogenous monocytes to the same fate.

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“…However, it is difficult to subsequently recover resident peritoneal macrophages after the onset of acute inflammation as they strongly adhere to peritoneal membranes, a poorly understood phenomenon described as macrophage disappearance reaction. 34 Thus, we performed in vitro studies to address whether X-CGD myeloid cells have a differential response to agonists inducing IL-1a. When challenged with necrotic lysates, X-CGD resident peritoneal macrophages released significantly higher amounts of both IL-1a and IL-1b, compared with WT cells ( Figure 3A).…”

Section: Ly6cmentioning

confidence: 99%