1995
DOI: 10.1002/jlb.57.3.361
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Review of the macrophage disappearance reaction

Abstract: Macrophages (M phi s) undergo a physiological response known as the macrophage disappearance reaction (MDR) in response to certain stimuli in the peritoneal compartment. The types of stimuli that can cause the MDR, the relationship of the MDR to the host immunological response, and the possible role of the MDR in M phi activation are reviewed. The data indicate that the MDR occurs in response to both acute nonspecific inflammatory and specific immune delayed hypersensitivity processes and that the MDR may play… Show more

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Cited by 156 publications
(134 citation statements)
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“…One hour after infection, the number of leukocytes collected by peritoneal lavage decreased in both Onzin Ϫ/Ϫ mice and controls, despite the initiation of neutrophil recruitment to the site of infection. This initial decrease in the number of leukocytes collected by peritoneal lavage after induction of peritonitis has been noted previously and is likely due to macrophage activation and adhesion of the cells to membranes within the peritoneal cavity (38,39). However, consistent with the elevated serum proteins recovered in the lavage fluid, the total leukocyte counts of the Onzin Ϫ/Ϫ mice are significantly higher than that of the control animals.…”
Section: Enhanced Response Of Onzinsupporting
confidence: 75%
“…One hour after infection, the number of leukocytes collected by peritoneal lavage decreased in both Onzin Ϫ/Ϫ mice and controls, despite the initiation of neutrophil recruitment to the site of infection. This initial decrease in the number of leukocytes collected by peritoneal lavage after induction of peritonitis has been noted previously and is likely due to macrophage activation and adhesion of the cells to membranes within the peritoneal cavity (38,39). However, consistent with the elevated serum proteins recovered in the lavage fluid, the total leukocyte counts of the Onzin Ϫ/Ϫ mice are significantly higher than that of the control animals.…”
Section: Enhanced Response Of Onzinsupporting
confidence: 75%
“…Within 1 h infection all macrophages disappear from the peritoneal wash (22). The function of this "macrophage disappearance reaction" is not understood, although it is likely that these peritoneal wash cells act as a strategic reserve that is mobilized on infection.…”
Section: Discussionmentioning
confidence: 99%
“…However, it is difficult to subsequently recover resident peritoneal macrophages after the onset of acute inflammation as they strongly adhere to peritoneal membranes, a poorly understood phenomenon described as macrophage disappearance reaction. 34 Thus, we performed in vitro studies to address whether X-CGD myeloid cells have a differential response to agonists inducing IL-1a. When challenged with necrotic lysates, X-CGD resident peritoneal macrophages released significantly higher amounts of both IL-1a and IL-1b, compared with WT cells ( Figure 3A).…”
Section: Ly6cmentioning
confidence: 99%