Review of the M.D. Anderson experience in the treatment of bladder sarcoma

Spiess, Philippe E.; Kassouf, Wassim; Steinberg, Jordan; Tuziak, Tomasz; Hernandez, Mike; Tibbs, Rita F.; Czerniak, Bogdan; Kamat, Ashish M.; Dinney, Colin P.; Grossman, H. Barton

doi:10.1016/j.urolonc.2006.02.003

Cited by 63 publications

(65 citation statements)

References 13 publications

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“…This is the key question for clinicians and the focus of this review. Patients with non-urothelial primary bladder cancer, such as pure squamous cell carcinoma, pure bladder sarcoma or pure adenocarcinoma, are known to have different outcomes, 9,10 and hence different management, when compared to urothelial carcinoma. It is unclear whether this result extends to urothelial cancer patients with divergent differentiation.…”

Section: Introductionmentioning

confidence: 99%

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Chalasani

Chin

Izawa

2013

CUAJ

156

113

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Bladder cancer can be classified histologically as urothelial or non-urothelial. Urothelial cancer has a propensity for divergent differentiation, which has increasingly been recognized in recent years due to heightened awareness and improved immunohistochemistry techniques. Furthermore, the recent World Health Organization classification of urothelial cancers improved clarity on this issue, with its listing of 13 histologic variants of urothelial cancer. The divergent differentiation patterns include, amongst others, squamous, glandular, micropapillary, nested, lymphepithelioma-like, plasmacytoid and sarcomatoid variants of urothelial cancer. Attempts to quantify the amount of divergent differentiation present, such as using the nonconventional differentiation number, have been made recently, which will improve the ability to compare publications from different centres. Genetic-based studies have indicated that the histologic variants of urothelial cancer arise from a common clonal precursor. Mostly, the current evidence suggests that urothelial cancer with divergent differentiation has a worse prognosis when compared with pure urothelial cancer. This article will review the current literature on variant histologies of urothelial cancer, and well as new developments in pure squamous cell carcinoma, small cell carcinoma and adenocarcinoma of the bladder.

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Section: Introductionmentioning

confidence: 99%

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Chalasani

Chin

Izawa

2013

CUAJ

156

113

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“…However, as chemotherapy is generally effective in treating patients with RMS, the concept of radiotherapy use has been partially modified and it is recommended on an individual basis (2,9). In adult RMS of the prostate or bladder, adjuvant radiotherapy is not regarded as necessary when the patient has undergone complete surgical resection and chemotherapy (23,24). In the present literature review, no patients received radiotherapy for the treatment of primary ITRMS.…”

Section: Discussionmentioning

confidence: 95%

Primary intratesticular rhabdomyosarcoma: A case report and literature review

Zhou

Huo

et al. 2015

Oncology Letters

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Abstract. Rhabdomyosarcoma (RMS) that primarily occurs in the testes is particularly rare, with only retrospective studies and sporadic cases reported in the literature. The present study describes the case of a large, primary intratesticular RMS (ITRMS) that was treated with a radical inguinal orchiectomy (RIO) and a regimen of chemotherapy. The study also presents a review of the literature regarding primary ITRMSs, aiming to elucidate the clinical characteristics and optimal treatment of the disease. A 14-year-old male presented with a 1-year history of a slow-growing, painless, left scrotal mass. Magnetic resonance imaging identified a mass in the left scrotum with mixed signal intensity; no abnormal signals were identified in the right testicle and retroperitoneal lymph node. An X-ray of the chest demonstrated no evidence of metastasis. Subsequent to this, a left RIO was performed. Histopathological and immunohistochemical examination confirmed the final diagnosis of embryonal ITRMS. At 21 days post-surgery, an 18

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“…Multimodal and individual treatment is preferable in patients who present with distant metastasis, and chemotherapeutic agent doxorubicin and ifosfamide are known to have the greatest response. 7 More recent studies suggest that bladder leiomyosarcoma may have a better prognosis than once believed, with a remarkable 5-year disease-specific survival rate of more than 50%. 6 …”

Section: Discussionmentioning

confidence: 99%

“…Whether neoadjuvant chemotherapy is given or not, surgical resection remains the cornerstone of treatment, with the surgical margin status being a strong predictor of outcome. 7 Conventionally, radical cystectomy with wide margins is the gold standard in cases where surgical resection is possible. Although strict adherence to standard surgical technique (radical excision of the tumour with en bloc removal of the bladder to encompass the prostate and seminal vesicles in men and the uterus, cervix and vaginal cuff in women) results in low rates of positive surgical margins and low rates of local tumour recurrence, the loss of bladder function and large surgical trauma significantly decreases the quality of postoperative life.…”

Section: Discussionmentioning

confidence: 99%

“…The overall recurrence of distant metastases is about 53%, the most common sites are the lungs, liver, bone and brain. 7 Therefore, a close surveillance with abdominopelvic CT, chest X-ray and cystoscopy should be performed, especially in the first year postoperatively, which may be conducive to the early diagnosis of tumour recurrence and metastasis. Local recurrences should be treated with systemic chemotherapy and/or pelvic external beam radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Partial cystectomy: Is it a reliable option for the treatment of bladder

Wang²,

Zheng³

et al. 2011

CUAJ

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Bladder leiomyosarcoma is a unique mesenchymal tumour, accounting for less than 0.5% of all primary bladder malignancies. Bladder leiomyosarcoma used to be treated with radical surgery in either old or young patients, often resulting in significant impact on the patients's quality of life after surgery. We report on a case of bladder leiomyosarcoma in a 31-year-old female who was treated with partial cystectomy. Fortunately, no tumour metastasis or relapse was observed during the 7-year follow-up period and the patient now has a good quality of life. We found that partial cystectomy may be an acceptable option to treat bladder leiomyosarcoma in the low MSKCC (Memorial Sloan-Kettering Cancer Center) stage.

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Review of the M.D. Anderson experience in the treatment of bladder sarcoma

Cited by 63 publications

References 13 publications

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Primary intratesticular rhabdomyosarcoma: A case report and literature review

Partial cystectomy: Is it a reliable option for the treatment of bladder

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