Review of the evidence of the effects of human papillomavirus infection and Gardnerella vaginalis, and their co-infection on infertility

Gholizadeh, Omid; Yekanipour, Zahra; Kivi, Setareh; Farahbod, Farnoosh; Aqayinejad, Mohadeseh; Tasoujizade, Yalda; Yasamineh, Saman; Amini, Parya; Akbarzadeh, Sama; Hajiesmaeili, Mehrnaz; Poortahmasebi, Vahdat

doi:10.1016/j.micpath.2023.105980

Cited by 11 publications

(9 citation statements)

References 89 publications

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“…Interesting, vaginal microecology can affect the process of HPV infection through various mechanisms. [ 26 , 27 ] Vaginal lactobacilli maintain a low pH, prevent HPV invasion, and produce bacteriocins, effectively inhibiting HPV entry into basal keratinocytes of the cervix. [ 28 ] Anaerobic bacteria in vaginal bacterial vaginosis produce enzymes and metabolites that may disrupt the barrier of cervical epithelial cells and promote HPV entry.…”

Section: Discussionmentioning

confidence: 99%

Analysis of HPV prevalence among individuals with reproductive tract infections in a Chinese population

Zhou,

Wang,

Wang

et al. 2023

Medicine

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The previous research has found that human papillomavirus (HPV) infection is the main cause of cervical cancer, but it is still unclear whether HPV infection, as well as the HPV genotypes, are related to reproductive tract infections in the Chinese population. Patients who underwent HPV screening at Shandong Maternal and Child Health Hospital were selected, and the HPV infection status was analyzed among patients with cervical lesions, bacterial vaginosis, cervical inflammation, fungal vaginitis, and pelvic infections. SPSS 22 statistical analysis was used to analyze the differences in HPV infection types and rates between the control group and the experimental group. The HPV infection rate of bacterial vaginosis (χ2 = 13.4; P < .001) and fungal vaginitis (χ2 = 3.3; P < .045) are both significantly different from the control group. The single HPV infections reveals significant differences from control group in bacterial vaginosis (χ2 = 7.3; P = .004), fungal vaginitis (χ2 = 4.5; P = .023), and cervical lesions (χ2 = 58.8; P < .001). In the bacterial infection group, HPV51 (1.9%; χ2 = 6.0; P = .008) and HPV58 (4.7%; χ2 = 3.3; P = .044) showed significant differences in infection compared to the control group. In the fungal infection group, HPV39 (2.7%; χ2 = 4.7; P = .032) showed a significant difference in infection compared to the control group. Cervical lesions, bacterial vaginosis, fungal vaginitis, and cervical lesions among Chinese population exhibit age-specified distribution. HPV infection rate in bacterial vaginitis, fungal vaginitis and cervical lesions was higher than that in normal group. HPV52 and HPV16 infection are different, and HPV39 is different between bacterial vaginitis and fungal vaginitis.

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Section: Discussionmentioning

confidence: 99%

Analysis of HPV prevalence among individuals with reproductive tract infections in a Chinese population

Zhou,

Wang,

Wang

et al. 2023

Medicine

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“…BV may create an environment that favors HPV persistence and progression to cervical dysplasia. 87,90,91 While less studied, other bacterial infections, such as Neisseria gonorrhoeae and Haemophilus ducreyi , have been reported in association with HPV infection. These coinfections may impact the clinical course, progression, and treatment outcomes of HPV-related diseases.…”

Section: Hpv Types Global Distributionmentioning

confidence: 99%

Human Papillomavirus Infection: Epidemiology, Biology, Host Interactions, Cancer Development, Prevention, and Therapeutics

Wolf

2023

Preprint

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Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections worldwide. It is caused by the human papillomavirus, a DNA virus that infects epithelial cells in various mucous membranes and skin surfaces. HPV can be categorized into high-risk and low-risk types based on their association with the development of certain cancers. High-risk HPV types, such as HPV-16 and HPV-18, are known to be oncogenic and are strongly associated with the development of cervical, anal, vaginal, vulvar, penile, and oropharyngeal cancers. These types of HPV can persist in the body for an extended period and, in some cases, lead to the formation of precancerous lesions that may progress to cancer if left untreated. Low-risk HPV types, such as HPV-6 and HPV-11, are not typically associated with cancer but can cause benign conditions like genital warts. Genital warts are characterized by the growth of small, cauliflower-like bumps on the genital and anal areas. Although not life-threatening, they can cause discomfort and psychological distress. HPV is primarily transmitted through sexual contact, including vaginal, anal, and oral sex. It can also be transmitted through non-penetrative sexual activities that involve skin-to-skin contact. In addition to sexual transmission, vertical transmission from mother to child during childbirth is possible but relatively rare. Prevention of HPV infection includes vaccination and safe sexual practices. HPV vaccines, such as Gardasil and Cervarix, are highly effective in preventing infection with the most common high-risk HPV types. These vaccines are typically administered to adolescents and young adults before they become sexually active. Safe sexual practices, such as consistent and correct condom use and limiting the number of sexual partners, can also reduce the risk of HPV transmission. Diagnosis of HPV infection can be challenging because the infection is often asymptomatic, especially in men. In women, HPV testing can be done through cervical screening programs, which involve the collection of cervical cells for analysis. Abnormal results may lead to further diagnostic procedures, such as colposcopy or biopsy, to detect precancerous or cancerous changes. Overall, HPV infection is a prevalent sexually transmitted infection with significant implications for public health. Vaccination, regular screening, and early treatment of precancerous lesions are key strategies to reduce the burden of HPV-related diseases and their associated complications. Education and awareness about HPV and its prevention are crucial in promoting optimal sexual health. This study aimed to carry out a literature review considering several aspects involving HPV infection: Global distribution, prevalence, biology, host interactions, cancer development, prevention, therapeutics, coinfection with other viruses, coinfection with bacteria, association with head and neck squamous cell carcinomas (HNSCC), and association with anal cancer.

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“…Some studies have shown an association between BV and HPV infection, particularly high‐risk HPV types. BV may create an environment that favours HPV persistence and progression to cervical dysplasia 93,96,97 …”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics

Wolf,

Kist,

Pereira

et al. 2024

Reviews in Medical Virology

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Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections worldwide. It is caused by the HPV, a DNA virus that infects epithelial cells in various mucous membranes and skin surfaces. HPV can be categorised into high‐risk and low‐risk types based on their association with the development of certain cancers. High‐risk HPV types, such as HPV‐16 and HPV‐18, are known to be oncogenic and are strongly associated with the development of cervical, anal, vaginal, vulvar, penile, and oropharyngeal cancers. These types of HPV can persist in the body for an extended period and, in some cases, lead to the formation of precancerous lesions that may progress to cancer if left untreated. Low‐risk HPV types, such as HPV‐6 and HPV‐11, are not typically associated with cancer but can cause benign conditions like genital warts. Genital warts are characterised by the growth of small, cauliflower‐like bumps on the genital and anal areas. Although not life‐threatening, they can cause discomfort and psychological distress. HPV is primarily transmitted through sexual contact, including vaginal, anal, and oral sex. It can also be transmitted through non‐penetrative sexual activities that involve skin‐to‐skin contact. In addition to sexual transmission, vertical transmission from mother to child during childbirth is possible but relatively rare. Prevention of HPV infection includes vaccination and safe sexual practices. HPV vaccines, such as Gardasil and Cervarix, are highly effective in preventing infection with the most common high‐risk HPV types. These vaccines are typically administered to adolescents and young adults before they become sexually active. Safe sexual practices, such as consistent and correct condom use and limiting the number of sexual partners, can also reduce the risk of HPV transmission. Diagnosis of HPV infection can be challenging because the infection is often asymptomatic, especially in men. In women, HPV testing can be done through cervical screening programs, which involve the collection of cervical cells for analysis. Abnormal results may lead to further diagnostic procedures, such as colposcopy or biopsy, to detect precancerous or cancerous changes. Overall, HPV infection is a prevalent sexually transmitted infection with significant implications for public health. Vaccination, regular screening, and early treatment of precancerous lesions are key strategies to reduce the burden of HPV‐related diseases and their associated complications. Education and awareness about HPV and its prevention are crucial in promoting optimal sexual health. This study aimed to carry out a literature review considering several aspects involving HPV infection: Global distribution, prevalence, biology, host interactions, cancer development, prevention, therapeutics, coinfection with other viruses, coinfection with bacteria, association with head and neck squamous cell carcinomas, and association with anal cancer.

show abstract

Review of the evidence of the effects of human papillomavirus infection and Gardnerella vaginalis, and their co-infection on infertility

Cited by 11 publications

References 89 publications

Analysis of HPV prevalence among individuals with reproductive tract infections in a Chinese population

Analysis of HPV prevalence among individuals with reproductive tract infections in a Chinese population

Human Papillomavirus Infection: Epidemiology, Biology, Host Interactions, Cancer Development, Prevention, and Therapeutics

Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics

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