Review of the Ethno-dentistry Activities of Calotropis gigantea

Ningsih, Diana Setya; Çeli̇k, İsmail; Abas, Abdul Hawil; Bachtiar, B. M.; Kemala, Pati; Idroes, Ghazi Mauer; Maulydia, Nur Balqis

doi:10.60084/mp.v1i1.31

Cited by 12 publications

(9 citation statements)

References 61 publications

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“…Indonesia is rich in plants that can be used for medicine [8][9][10]. One notable medicinal plant in Indonesia is the leilem plant (Clerodendrum minahassae), which is endemic to North Sulawesi.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Test of Antioxidant Activity of Leilem Leaf Ethanol Extract (Clerodendrum minahassae) Using DPPH and FRAP Methods

Malino,

Kepel,

Budiarso

et al. 2024

Heca J. Appl. Sci.

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The risk of degenerative diseases is increasing due to unhealthy lifestyles. Many people consume junk food, smoke, and do not protect themselves from sun exposure and pollution, exposing their bodies to free radicals. Free radicals can cause oxidative stress, necessitating the need for antioxidants to neutralize them. The leilem plant (Clerodendrum minahassae) is an endemic plant from North Sulawesi that is often used in traditional dishes and medicine. Moreover, leilem leaves are believed to be a source of natural antioxidants. This study aimed to determine the efficacy of leilem leaf ethanol extract as a source of antioxidants. The antioxidant potential was evaluated using phytochemical screening and antioxidant assays such as 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) methods, with ascorbic acid as a comparison. The level of antioxidant activity was measured by determining the IC50 value, which corresponds to the concentration of extract required to inhibit 50% of free radicals. The results of phytochemical screening showed that the ethanol extract of leilem (Clerodendrum minahassae) leaves contains active compounds such as phenols, flavonoids, saponins, tannins, steroids/triterpenoids, and alkaloids, indicating a high potential for antioxidant activity. The IC50 value for the DPPH method was 78.799 ppm, and the IC50 value for the FRAP method was 92.127 ppm. These results demonstrate that the ethanol extract of leilem leaves has strong antioxidant activity in both the DPPH and FRAP methods.

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Section: Introductionmentioning

confidence: 99%

In Vitro Test of Antioxidant Activity of Leilem Leaf Ethanol Extract (Clerodendrum minahassae) Using DPPH and FRAP Methods

Malino,

Kepel,

Budiarso

et al. 2024

Heca J. Appl. Sci.

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“…Utilizing bioinformatic assays like molecular docking is one of the most time-and cost-efficient high-throughput approaches [13,14]. A computer research method called molecular docking integrates the disciplines of biology and chemistry to forecast interactions between various molecules, including ligands and proteins.…”

Section: Introductionmentioning

confidence: 99%

“…A computer research method called molecular docking integrates the disciplines of biology and chemistry to forecast interactions between various molecules, including ligands and proteins. These interactions can provide information that makes it less difficult to find drug targets, side effects, and drug resistance [13][14][15][16]. The aim of this study is to explore the interactions between ligands from C. gigantea in the Ie Jue, geothermal zone of mount Seulawah Agam and the proteins from the halitosis-causing bacteria P. gingivalis.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Antibacterial Potential of C. Gigantea in the Geothermal Area of Ie Jue: A Bioinformatics Approach

NINGSIH,

IDROES,

KHAIRAN

et al. 2024

Int J App Pharm

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Objective: The Aceh geothermal region offers an enticing possibility for research into prospective contributions to the medical field, particularly in dentistry. C. gigantea, a hardy plant that can withstand high temperatures, grows in this area. Methods: This plant contains a large number of secondary metabolites that are known to be useful in herbal medicine. However, there has not been much research done in this field of oral health; thus finding the plant's potential will require a cheap detecting tool. One method for this investigation is molecular docking, which is a part of bioinformatics. Molecular docking is a method used to examine how drugs interact with proteins, such as the proteins from the halitosis-related bacteria Porphyromonas gingivalis (P. gingivalis). Results: In this study, computational technologies will be used to find antibacterial properties. In particular, the antibacterial effects of chemical compounds from Biduri leaves (C. gigantea) discovered in the Ie Jue geothermal zone are examined. The study uses molecular docking to compute the interactions of the five Biduri metabolites: lupenyl acetate, α-amyrin, phytol, β-amyrenyl acetate, and methyl ester with the Kgp protein in P. gingivalis. Conclusion: The data show a range of binding affinities, with α-amyrin showing the most promising results with a binding affinity of -9.7 kcal/mol for Kgp protein. According to this study, P. gingivalis, the bacteria that cause halitosis, may be susceptible to the antibacterial effects of C. gigantea leaves.

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“…

Along with technological advancements, innovation is imperative in the formulation of toothpaste, incorporating additional substances that promote dental health while ensuring safety [8][9][10]. One such addition is herbal ingredients known for their antibacterial properties.

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mentioning

confidence: 99%

Impact of Cocoa Seed Extract Toothpaste on Plaque Reduction in Pediatric Populations

Nuraskin,

Salfiyadi,

Reca

et al. 2024

Grimsa J. Sci. Eng. Technol.

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Plaque is a soft deposit that forms a helical biofilm layer and attached tightly to the tooth surface, in which its presence requiring the use of specific control agents. The safest and most effective plaque control is to use a toothbrush and toothpaste. On the other hand, extract from Theobroma cacao L. seeds contains antioxidant and antibacterial secondary metabolites which could act as a toothpaste active agent. The aim of this research was to determine the impact of Theobroma cacao L. seeds-added toothpaste in reducing plaque index of among children. This is a non-blinding clinical experiment with a pre-test and post-test research design. The research subjects were 30 healthy children aged 8-10 years which were randomly divided into three arms (treatment and control). The results revealed that Theobroma cacao L. extract used as the active ingredient contained contains phenolics, tannins, flavonoids, terpenoids, saponins, and alkaloids. Significantly higher plaque index reductions were observed among children treated with toothpaste containing 1% (mean difference=2.060; p=0.06) as compared to control. In conclusion, the Theobroma cacao L. seeds-added toothpaste could significantly reduce plaque index among healthy children.

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Review of the Ethno-dentistry Activities of Calotropis gigantea

Cited by 12 publications

References 61 publications

In Vitro Test of Antioxidant Activity of Leilem Leaf Ethanol Extract (Clerodendrum minahassae) Using DPPH and FRAP Methods

In Vitro Test of Antioxidant Activity of Leilem Leaf Ethanol Extract (Clerodendrum minahassae) Using DPPH and FRAP Methods

Exploring the Antibacterial Potential of C. Gigantea in the Geothermal Area of Ie Jue: A Bioinformatics Approach

Impact of Cocoa Seed Extract Toothpaste on Plaque Reduction in Pediatric Populations

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