Review of the Efficacy, Durability, and Safety Data of Two Nonanimal Stabilized Hyaluronic Acid Fillers from a Prospective, Randomized, Comparative, Multicenter Study

Abstract

Although both NASHA fillers demonstrated similar efficacy, durability, and safety, the fanning injection technique, and a faster rate of injection played a key role in the increase in incidence of adverse experiences. Furthermore, the safety of each NASHA product was demonstrated at volumes well beyond the volume range listed on the product inserts.

Letter: Foreign Body Reaction to Hyaluronic Acid Filler Injection: In Search of an Etiology

“…[1][2][3][4] Complications caused by the injection of HA can be secondary to the implantation procedure itself or the implanted material. For example, erythema and edema are expected, unwanted side effects and are most likely due to the hydrophilic properties of HA.…”

Soft tissue augmentation for facial lipoatrophy and volumization

“…Postinjection swelling, erythema, and bruising are not atypical and may be more prolonged than with other HA fillers. When comparing small particle gels and large particle gels, they both demonstrate similar efficacy, durability, and safety [6]. Perlane has also been shown to be effective for the treatment of HIV lipoatrophy.…”

Macrolane for Volume Restoration and Contouring of the Buttocks

“…Although nonanimal stabilized hyaluronic acid gel is no longer marketed for the breast because of an ongoing debate regarding issues with radiologic imaging, numerous studies have found that the injection of the gel for breast and facial aesthetic procedures is effective and well tolerated. [8][9][10][11][12][13][14] Magnetic resonance imaging can be used to distinguish between muscle and fat in tissue and has been used in the past to determine degradation rates and localization of fat after autologous fat grafting of the buttocks. 15,16 Magnetic resonance imaging has also been used to visualize nonanimal stabilized hyaluronic acid gel within the breasts.…”