Review of the computational models for the signaling pathway

Abstract

Abstract.In the past few years, systems biology methods have been widely used to explore the mechanism of cancer. Various signaling pathways play the important role in cancer. And a large number of computational methods are used to model the signaling pathway. Here, we reviewed many existing mechanisms and modeling techniques, which are used to model different signaling pathways. Then we introduced the systematic workflow of a system biology approach and some fundamental analysis methods. Finally we discuss some known challenges in the process of modeling signaling pathways and what we should handle in our future work.