Review of Synthesis of 1,3,4-Oxadiazole Derivatives

Synthesis and biological activity of 1,3,4-oxa(thia)diazole, 1,2,4-triazole-5-(thio)one and S-substituted derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid

“…Bistriazolethione 13 has shown excellent antioxidant activity of 95 %. Just slightly lower free radical scavenging activity has been identified for Salkylated triazole derivatives possessing phenacyl fragment (23)(24)(25) in their structure. S-alkylated triazole derivatives 15-27 exhibit significant antimicrobial activity.…”

“…Cyclization of hydrazine derivatives is a well-known method for the synthesis of polyfunctionalized derivatives of 1,3,4-thiadiazole, 1,3,4-oxadiazole, and 1,2,4-triazole [3,23,24].…”

“…Graphical Abstract Synthesis of compounds 2-27. R: 2,5,7,10,13,[15][16][17][18][19][20][21][22][23][24][25][26][27]3,8,4,9,12 …”

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis­ Using Diverted Umpolung Amide Synthesis

“…1 Another large group of approaches involve oxidative transformations of an aromatic heterocycle’s precursor. 2 Syntheses of both 1,3,4-oxadiazoles 3,4,5 and 1,2,4-triazoles largely fall into these two categories. 6 Collectively, these approaches often invoke the use of highly electrophilic reagents or strong oxidants, and some have noted the inefficient nature (i.e.…”

Strategies for the Efficient Synthesis of Biheterocyclic 5-[2-(Trifluoromethylheteroaryl)-ethyl]-1,3,4-oxadiazoles from Levulinic Acid

“…4 The ability of 1,3,4-oxadiazole heterocyclic compounds to undergo various chemical reactions has made them important for molecule planning, which has enormous biological potential. [6][7][8][9][10][11][12][13] Recently we have reported the synthesis of methyl 1,1,1-trifluoro-4-methoxy-6-oxo-4-heptenoate as a building block for trifluoromethyl containing heterocyclic systems. This substrate has three electrophilic centers allowing its use in [4 + 1], [3 + 2], and [3 + 3] cyclocondensation processes, as shown in Scheme 1.…”