Review of Siebers's Disability Aesthetics

Abstract

No abstract available

Nitric Oxide-Releasing Alginates as Mucolytic Agents

“…Formation of the Ndiazeniumdiolate NO donors was confirmed by UV-vis spectroscopy and the appearance of a characteristic absorbance band at 253 nm ( Figure S8). 16 The resulting N-diazeniumdiolatemodified alginates possessed a broad range of NO payloads and release kinetics (Table 1), with Alg5-PAPA/NO and Alg5-DETA/NO having the fastest and shortest NO-release halflives (0.1 and 2.0 h, respectively). Overall, the NO payloads were comparable to that of previously reported water-soluble systems (0.3-0.6 μmol/mg; Table 1).…”

“…Nitric oxide (NO), an endogenously-produced free radical, holds promise as a potential therapeutic agent for treating respiratory diseases due to its broad spectrum antibacterial activity against planktonic and biofilm-based bacteria. [8][9][10][11][12][13][14][15] Present studies indicated that bacteria are unlikely to foster resistance to NO owing to the multi-mechanistic pathways (e.g., nitrosation of thiols on bacterial proteins) involved in NO's antibacterial action. 16,17 While initial studies have demonstrated the efficacy of exogenous NO in the gas form, the hazards associated with the use of pressurized cylinders and NO's high reactivity in biological media has to date limited its therapeutic utility.…”

“…[8][9][10][11][12][13][14][15] Present studies indicated that bacteria are unlikely to foster resistance to NO owing to the multi-mechanistic pathways (e.g., nitrosation of thiols on bacterial proteins) involved in NO's antibacterial action. 16,17 While initial studies have demonstrated the efficacy of exogenous NO in the gas form, the hazards associated with the use of pressurized cylinders and NO's high reactivity in biological media has to date limited its therapeutic utility. 18 Research has thus also focused on the development of water soluble macromolecules capable of storing and releasing NO under specific environmental conditions as an alternative to direct NO inhalation.…”