Review of Scabies Infestation and Selected Common Cutaneous Infections

Brockman, Ross; Leitenberger, Sabra

doi:10.1542/pir.2018-0305

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…Group A received 400 mg/day oral albendazole for three consecutive days at first and second week, as recommended for soil-transmitted helminth infection [16]. Group B was applied permethrin 5% cream throughout the body at night on the first and second week as previously recommended [17]. Clinical evaluation was done every week for four weeks by experienced investigators blinded to the treatments received.…”

Section: Treatment Measurement and Evaluationmentioning

confidence: 99%

Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia

Azmi¹,

Fitrianingrum²,

Fiqri³

et al. 2022

IJCEMS

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Scabies is a skin disease caused by Sarcoptes scabiei infestation and is classified as a neglected tropical disease (NTD). Permethrin 5% is the first-line treatment for scabies. However, adherence and accuracy in topical creams are common problems. Thus, it is necessary to think of alternative medication that is more accessible, more straightforward, and lower the risk of resistance. Albendazole appears to be an alternative therapy for eradicating scabies in the community base. Sixty subjects diagnosed with scabies were recruited and divided into two groups with randomization. The first group was given 400 mg oral albendazole for three consecutive days on the first and second week. The second group was applied permethrin 5% to the whole body once on the first night of the first and second week. The evaluation was carried out for four weeks, and improvement was stated absence of new lesions and healing of old lesions and pruritus. Data were analyzed using SPSS software (version 25, SPSS Inc., Chicago., IL). The X 2 test was used to examine the difference between groups, and p < 0.05 was considered significant. The cure rate of albendazole was significantly superior to permethrin topical (90.0% vs. 63.3%) with a p-value of 0.015. This study revealed the effectiveness of oral albendazole 400 mg/day for three consecutive days in the first and second weeks for treating scabies to topical permethrin 5%. No side effect seen in the use of albendazole and topical permethrin during the study. Albendazole could be an alternative drug option to eradicate scabies in low-middle-income countries.

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Section: Treatment Measurement and Evaluationmentioning

confidence: 99%

Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia

Azmi¹,

Fitrianingrum²,

Fiqri³

et al. 2022

IJCEMS

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“…In high-income countries, delays in diagnosing scabies may be due to reduced familiarity with this disorder among non-dermatologists. This diagnostic delay can lead to outbreaks in daycare facilities, schools, and other institutions [9]. The International Alliance for the Control of Scabies (IACS) recently developed international consensus diagnostic criteria and guidelines for common scabies [10].…”

Section: Introductionmentioning

confidence: 99%

National survey in Switzerland calls for improved diagnosis and treatment in children with scabies

Buettcher

2023

Swiss Med Wkly

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AIM OF THE STUDY: The global prevalence of scabies is estimated to be up to 200 million cases annually, with young children particularly affected. In Europe, most cases are thought to originate in migrant populations. Scabies management is challenging in children. To identify knowledge gaps and research needs, we aimed to descriptively evaluate the management of children with scabies by different Swiss healthcare providers. METHODS: An invitation for an anonymous online survey (36 questions) was sent to members of Swiss societies of dermatologists, general practitioners, paediatricians, paediatric dermatologists, paediatric infectious diseases specialists, and tropical medicine specialists, inviting clinicians to participate from 25th May to 8th August 2020. One reminder invitation was sent. Hospital pharmacies and the distributor of permethrin were contacted to report consumption trends of scabicides in 2018 and 2019. RESULTS: The survey was completed by 248 clinicians: 146 (59%) paediatricians, 47 (19%) dermatologists, 28 (11%) general practitioners, 6 (2%) paediatric dermatologists, 13 (5%) paediatric infectious diseases specialists, and 8 (3%) tropical medicine specialists. Most consulted up to 10 scabies cases within a 16-month period, with similar numbers in migrant and Swiss children. Dermoscopy was used by 24% of non-dermatologists. Non-dermatologists did not consider co-treatment of close contacts in up to 59% of cases. While permethrin was the first-line treatment, treatment failures were frequently reported in children aged <5 years. Up to 67% of paediatric dermatologists regularly used oral ivermectin off-label in children weighing <15 kg. None of the paediatric dermatologists, 15% of the dermatologists, and 9% of the non-dermatologists used only one treatment cycle.Scabicide consumption increased. Treatment studies on ivermectin use in children weighing <15 kg had the highest research priority. CONCLUSION: In Switzerland, scabies is a frequent dermatosis in migrant and Swiss children. While accessible, optimal diagnostics are underutilised, and treatment is suboptimal. Permethrin resistance appears to be an increasing problem. Dermatologists regularly use ivermectin off-label in children weighing <15 kg. Treatment studies on ivermectin use in children weighing <15 kg, user-friendly diagnostic tools, new treatment protocols, and child-friendly dosage forms are needed to improve the diagnosis and treatment of children with scabies.

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Review of Scabies Infestation and Selected Common Cutaneous Infections

Cited by 2 publications

References 41 publications

Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia

Oral Albendazole Is Superior to Permethrin 5% for Scabies Treatment in Boarding School Indonesia

National survey in Switzerland calls for improved diagnosis and treatment in children with scabies

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