Recently while attending a pathologicoclinical conference devoted exclusively to the demonstration of material obtained from children at autopsy, which is conducted once each month by Dr. Richard H. Jaff\l =e' \, director of the department of pathology of the Cook County Hospital in Chicago, I was much impressed by the gross demonstration of several infants' hearts. The first specimen, from a baby 4 months old, showed marked hypertrophy and dilatation. The musculature was reddish brown and occupied a large space in the thoracic cavity. Before death the child presented symptoms of cyanosis and marked dyspnea. Dr. Jaff\l=e'\thought that the condition shown by this specimen belonged to the yet unexplained group of idiopathic cardiac hypertrophies.The second specimen came from an infant about 7 months old who had suffered from a severe anemia. The heart was pale, whitish and markedly increased in size. The right heart was dilated, though the myocardium was not as firm as in the former case. Careful postmortem examination, including the inspection of bone marrow and of the spleen, as well as of lymphatic tissues, threw no light on the nature of the anemia. Examination of the blood during life gave results correspond¬ ing to the findings in a severe case of secondary anemia. I became reflective about the possible nature of these unexplained morbid processes. I recalled that formerly as a member of the attend¬ ing staff in hospital service I was not infrequently approached by a younger member of the house staff and asked to suggest a subject for investigation or for a paper. Unless I had something definitely in mind, I often told the young man to note carefully on his daily rounds among his patients all the facts about a certain disease which were known or thought to be known and, on the contrary, all points which were in doubt or unknown. Then I suggested to him that if he would take for his subject one of the unknown facts about a certain disease and work with the idea of solving the problem, he not only would become a dis¬ coverer but would also learn the technic and methods of original inves¬ tigation. It is needless to say that only a few of the young men were eager to adopt my suggestion.