Review of Recent Studies on Statistical Optimization  in Drug Delivery Technologies

Patil, Sumit; Yeramwar, Shriniwas; Sharma, Pankaj Kumar; Bhargava, Anurag

doi:10.22270/jddt.v4i5.954

Cited by 3 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…Final formulation parameters are then defined using optimization, where the levels of all critical factors are determined. [27][28] Central composite design (CCD) is second-order design most frequently employed to study & optimize tablet formulations. Using CCD, response surfaces that permit the rating of each factor depending on its significance on the responses studied are possibly created.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, these designs are extensively used to optimize various drug delivery technologies such as sustained-release tablets, liposomes, microspheres and nanoparticles. 28 This study aims to investigate and optimize the effect of non-conventional used Cajanus cajan starch (CCS) concentrations and wet massing granulation time on physicochemical properties of metronidazole (MNA) tablets.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Optimization of Immediate Release Cajanus Cajan Starch-Based Tablets Containing Metronidazole

Abdelgader

Abdallah

Hamedelniel

et al. 2020

Orient J Phys Sciences

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Starch is found almost in all organs of plants as a carbohydrate reserve. It is considered one of the most commonly used pharmaceutical additives, mainly in tablet dosage forms; it used as a tablet binder when incorporated through the wet granulation process or as a disintegrant. Cajanus cajan has a high level of carbohydrate, which makes it another potential choice as a source for starch. This study aims to investigate and optimize the effect of Cajanus cajan starch concentrations as well as wet massing granulation time on physicochemical properties of metronidazole tablets. The hardness, friability percentage, and disintegration time of prepared tablets were determined, and the central composite design was employed in the optimization process. Then the tablets of optimized batch were compared against those tablets in which maize starch and sodium starch glycolate were used instead of Cajanus cajan starch. The results indicated that metronidazole tablets containing the upper level of starch paste (Cajanus cajan and/or maize starch paste) exhibited better percentage friability, hardness, and disintegration time than those formulated with lower levels and those without starch paste. The study showed that experimental design is a useful technique for optimizing Cajanus cajan starch-based tablets, which enabled a better understanding of how different variables could affect the responses. In addition, the study demonstrated that incorporation of Cajanus cajan starch in tablets formulation led to improvement of its physical properties compared to the formulations of maize starch and sodium starch glycolate respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Immediate Release Cajanus Cajan Starch-Based Tablets Containing Metronidazole

Abdelgader

Abdallah

Hamedelniel

et al. 2020

Orient J Phys Sciences

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“…Further it allows efficient experimentation covering a large number of factors which are varied together over a set of experiments, in contrast with the traditional approach of varying each factor while keeping other factors constant, which may fail to identify any interactions between these factors. [8,9,10] In current study, a computer-aided optimization technique using a three factor, two-level, full factorial design was used to investigate the effect of three formulation variables, i.e., concentration of Eudragit L 100-55, Diethyl phthalate and Polyethylene Glycol 6000. Table 1).…”

Section: Introductionmentioning

confidence: 99%

Quality by Design (QbD) approach to optimize the formulation of Multiunit Particulate System (MUPS).

Reddy¹

2019

JCPR

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The objective of this study was to develop and evaluate a MUPS formulation intended for treatment digestive tract ulcers.Work involves evaluation of different formulations of esomeprazole magnesium having enteric polymer and plasticizers to understand impact on dissolution. A three-factor, two-level, full factorial design was used to investigate the influence of Eudragit L 100 55, Diethyl phthalate and Polyethylene glycol 6000 of the coating composition on the response, i.e., dissolution. Eudragit L 100-55 and Diethyl phthalate had a significant influence on dissolution, while Polyethylene glycol 6000 within studied level showed nonsignificant impact. Graphical analysis from pare to chart and half normal plots, enabled identification of variables active on the selected responses. The optimized formulation comprised of Eudragit L-100-55: 46.42mg/tablet, Diethyl phthalate: 6.14mg/tablet and Polyethylene glycol 6000: 0.71mg/tablet showed acid resistance and a desired release of Esomeprazole magnesium. Gastro-resistant MUPS formulation has been successfully developed for Esomeprazole Magnesium.

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Optimization of bilayer tablet manufacturing process for fixed dose combination of sustained release high-dose drug and immediate release low-dose drug based on quality by design (QbD)

Won

Park

et al. 2021

International Journal of Pharmaceutics

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Review of Recent Studies on Statistical Optimization in Drug Delivery Technologies

Cited by 3 publications

References 4 publications

Formulation and Optimization of Immediate Release Cajanus Cajan Starch-Based Tablets Containing Metronidazole

Formulation and Optimization of Immediate Release Cajanus Cajan Starch-Based Tablets Containing Metronidazole

Quality by Design (QbD) approach to optimize the formulation of Multiunit Particulate System (MUPS).

Optimization of bilayer tablet manufacturing process for fixed dose combination of sustained release high-dose drug and immediate release low-dose drug based on quality by design (QbD)

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