Review of Prevalence and Outcome of Vascular Disease in Patients with Diabetes Mellitus

Weiss, Jeffrey; Sumpio, Bauer E.

doi:10.1016/j.ejvs.2005.08.015

Cited by 83 publications

(53 citation statements)

References 63 publications

(152 reference statements)

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“…Weiss and Sumpio reported in a meta-analysis that graft patency was equivalent in patients with and without diabetes. 18 A Swedish study found a lower amputation-free survival rate in diabetic patients after leg bypass surgery, 19 contrary to the findings of the present study. These other reports, however, included differing preoperative patient profiles, severity of disease, operative procedures and follow-up systems.…”

Section: Discussioncontrasting

confidence: 57%

Diabetes and Old Age Could Affect Long-Term Patency of Paramalleolar Distal Bypass for Peripheral Arterial Disease in Japanese Patients

Komai

Obitsu

Shigematsu

2011

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp istal bypass has been established as the most effective treatment for critical limb ischemia of peripheral arterial disease (PAD). In particular, bypass to the paramalleolar arteries is considered to enable complete revascularization through the pedal lesion. It is still a challenging procedure, however, because the long-term patency rate is not satisfactory, despite recent progress in surgical techniques and postoperative management. Early graft failure might be due to poor anastomotic technique, presence of inadequate run-off vessels, or marked calcification of the target artery and/or poor quality of the conduit vein. Although many papers have been published concerning the long-term patency of distal bypass, 1-3 the factors subsequently affecting the patency rate have not yet been elucidated. In the present report, data were reviewed and the factors affecting long-term patency were investigated. Patient background profile and technical factors involved in the distal bypass operation to the paramalleolar tibial artery were considerably similar in each patient due to the presence of similar risk factors of atherosclerosis and coexistent atherosclerotic vascular diseases. The extent of the disease was similar, variation in surgical techniques was limited, and surgical procedures and postoperative care were uniform in general. Thus, we believe that it would be beneficial to analyze the results of paramalleolar distal bypass to elucidate the risk factors of graft failure. In particular, Japanese subjects are very homogeneous genetically, 4,5 which favors determination of the substantial factors involved in graft failure. MethodsWe retrospectively studied 65 legs of 60 consecutively treated Japanese patients (49 men, 11 women; age range, 42-87 years; average, 70.5 years) with PAD who underwent distal bypass to the paramalleolar tibial artery (artery supplying the distal third of the calf) 6 for critical limb ischemia (Table 1). All the patients had lower extremity ischemic ulcer or necrosis. Ankle brachial pressure index, skin perfusion pressure and angiography showed the lesions to be of ischemic origin, and they met the criteria for critical limb ischemia in the Trans-Atlantic Inter-Society Consensus (TASC) guidelines. Comorbidity factors consisted of diabetes in 43 patients (66%), hypertension in 42 (65%), dyslipidemia in 12 (18%), chronic renal failure Background: The results of paramalleolar distal bypass for critical limb ischemia in patients with peripheral arterial disease were reviewed to determine the factors affecting the long-term patency of this procedure in Japanese subjects.

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Section: Discussioncontrasting

confidence: 57%

Diabetes and Old Age Could Affect Long-Term Patency of Paramalleolar Distal Bypass for Peripheral Arterial Disease in Japanese Patients

Komai

Obitsu

Shigematsu

2011

Circ J

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“…In the developed world, diabetes is the most significant cause of adult blindness in the non-elderly and the leading cause of non-traumatic amputation in adults, and diabetic nephropathy is the main illness requiring renal dialysis in the USA [65].…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Pharmacological significance of triazole scaffold

Kharb

Sharma

Yar

2010

Journal of Enzyme Inhibition and Medicinal Chemistry

469

236

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“…11 Even more strikingly, in contrast to the strong association of diabetes mellitus with arterial obstructive disease, large epidemiology screening studies demonstrated either a negative association or no association between diabetes and AAA. 12 In a screening study of 73 451 men, Lederle and colleagues 3 found that the detection of an AAA on ultrasound screening was approximately half as likely in patients with diabetes as in nondiabetic patients. Moreover, the progression of AAA was shown to be slower in patients with diabetes, which suggests a pathobiological mechanism by which the aortic media may be protected from aneurysmal degradation in these individuals.…”

mentioning

confidence: 99%

Determinants of Aneurysmal Aortic Disease

Diehm

Baumgartner

2009

Circulation

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Review of Prevalence and Outcome of Vascular Disease in Patients with Diabetes Mellitus

Abstract: Stroke, graft patency, and limb salvage rates in patients with diabetes after surgery are similar to patients without diabetes; however, their risk of complications is increased after surgery and the mortality risk may be higher after CEA.

Cited by 83 publications

References 63 publications

Diabetes and Old Age Could Affect Long-Term Patency of Paramalleolar Distal Bypass for Peripheral Arterial Disease in Japanese Patients

Diabetes and Old Age Could Affect Long-Term Patency of Paramalleolar Distal Bypass for Peripheral Arterial Disease in Japanese Patients

Pharmacological significance of triazole scaffold

Determinants of Aneurysmal Aortic Disease

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