Review of Prediabetes

Metformin: An Important Treatment Consideration for Persons with Prediabetes Taking Antipsychotics

“…5 Metformin has numerous randomized control trials supporting its use to prevent and delay type 2 diabetes and is used worldwide to treat prediabetes. 4,6 Despite this, the US Food and Drug Administration has not approved metformin or any other pharmacologic agent to treat prediabetes. 4 Thus, prescribing metformin for prediabetes is technically considered off-label.…”

“…4,6 Despite this, the US Food and Drug Administration has not approved metformin or any other pharmacologic agent to treat prediabetes. 4 Thus, prescribing metformin for prediabetes is technically considered off-label. However, the American Diabetes Association (ADA) denotes metformin therapy as a consideration for individuals with prediabetes, especially those with BMI ≥35 kg/m 2 , those age <60 years, and women with a history of gestational diabetes (Table 2).…”

“…Lifestyle modification is the first-line intervention to address prediabetes, but metformin can also be considered as a treatment option. 2,4 Metformin decreases serum glucose by reducing gluconeogenesis and increasing systemic glucose disposal. 5 Metformin has numerous randomized control trials supporting its use to prevent and delay type 2 diabetes and is used worldwide to treat prediabetes.…”