Review of Porphyrin Derivatives and Application in Photodynamic Therapy

Annunzio, Sarah Raquel de; Costa, Natalia Caroline Silva

doi:10.31219/osf.io/zmu7a

Cited by 1 publication

(1 citation statement)

References 87 publications

(118 reference statements)

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“…Photodynamic therapy (PDT) has garnered attention as a less invasive treatment option for various cancer types and infectious diseases, including bacteria-infected wounds, acne vulgaris, human papillomavirus viral warts, and cutaneous leishmaniasis [ 1 , 2 , 3 ]. Notably, PDT demonstrates remarkable advantages in treating solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Kim,

Chang

2023

Pharmaceutics

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Photodynamic therapy (PDT) is an emerging and less invasive treatment modality for various types of cancer. This review provides an overview of recent trends in PDT research, ranging from basic research to ongoing clinical trials, focusing on different cancer types. Lung cancer, head and neck cancer, non-melanoma skin cancer, prostate cancer, and breast cancer are discussed in this context. In lung cancer, porfimer sodium, chlorin e6, and verteporfin have shown promising results in preclinical studies and clinical trials. For head and neck cancer, PDT has demonstrated effectiveness as an adjuvant treatment after surgery. PDT with temoporfin, redaporfin, photochlor, and IR700 shows potential in early stage larynx cancer and recurrent head and neck carcinoma. Non-melanoma skin cancer has been effectively treated with PDT using methyl aminolevulinate and 5-aminolevulinic acid. In prostate cancer and breast cancer, PDT research is focused on developing targeted photosensitizers to improve tumor-specific uptake and treatment response. In conclusion, PDT continues to evolve as a promising cancer treatment strategy, with ongoing research spanning from fundamental investigations to clinical trials, exploring various photosensitizers and treatment combinations. This review sheds light on the recent advancements in PDT for cancer therapy and highlights its potential for personalized and targeted treatments.

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Section: Introductionmentioning

confidence: 99%