Review of Peripheral Giant Cell Granulomas

Boffano, Paolo; Benech, Rodolfo; Roccia, Fabio; Gallesio, Cesare; Garzaro, Massimiliano; Pecorari, Giancarlo

doi:10.1097/scs.0b013e31829a8316

Cited by 15 publications

(31 citation statements)

References 25 publications

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“…The second most common site for PGCG was posterior maxilla (21%), whereas anterior mandible was involved in CGCG (19.45%). In contrast to our results Boffano et al showed maxilla as the most frequent site for PGCGs 19 . The clinical features of CGCGs varied considerably and is hard to predict 9 .…”

Section: Resultscontrasting

confidence: 99%

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

Saghafi

Zare-Mahmoodabadi

Ghazi

et al. 2016

Bangladesh J Med Sci

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Abstract:Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (PGCGs) in Iranian population. Methods: The data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to our department between 1972 and 2010. This 38-year retrospective study was based on existing data. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented. Results: A total of 1019 patients were affected GCGLs including 435 CGCGs and 584 PGCGs during the study. The mean age was 28.91 ± 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases (57.70%), whereas PGCGs were more frequent in males (50.85%). Five hundred and ninety-eight cases of all giant cell lesions (58.7 %) occurred in the mandible. Posterior mandible was the most frequent site for both CGCG and PGCG cases. The second most common site for PGCG was posterior maxilla (21%), whereas anterior mandible was involved in CGCG (19.45%). The majority of patients were asymptomatic. Conclusions: In contrast to most of previous studies PGCGs occur more common in the first decade and also more frequently in male patients. Although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations which may help in the diagnosis and management of these lesions.

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Section: Resultscontrasting

confidence: 99%

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

Saghafi

Zare-Mahmoodabadi

Ghazi

et al. 2016

Bangladesh J Med Sci

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“…Increased prevalence occurs when lesions present posteriorly, possibly related to difficult access for oral hygiene or occlusal load experienced posteriorly, as opposed to that experienced by the anterior teeth. Boffano et al . reported overall PGCG recurrence of 10.5% in the first 36 months post‐surgery associated with initial presence of ulceration.…”

Section: Discussionmentioning

confidence: 99%

“…Even though the etiopathogenesis of this lesion is still unclear, PGCG is commonly associated with local irritating factors such as ill‐fitting dental restorations and dentures, complex tooth extraction, dental implants, systemic disease, food impaction, plaque, and calculus as well as chronic trauma …”

Section: Introductionmentioning

confidence: 99%

Esthetic Management of Peripheral Giant Cell Granuloma Affecting a Dental Implant in the Esthetic Zone

Mordini

2019

Clin Adv Periodontics

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Introduction A size increase of the gingiva can be a manifestation of gingival disease. While gingival lesions can affect periodontal tissue, only few reports described the association between peripheral giant‐cell granuloma (PGCG) with dental implants and their clinical management. Their clinical relevance is of a great interest since some lesions may lead to extensive bone resorption, esthetic alterations, or even tooth/implant loss. To the author's best knowledge, no specific guidelines for the treatment of PGCG affecting dental implant in the esthetic zone have been reported. The aim of this paper was to report an extensive PGCG associated with a dental implant in the esthetic area and its surgical management. Case Presentation A 39‐year‐old suffered from concussive trauma on her anterior maxillary dentition leading to an expanded, purplish soft tissue lesion surrounding the implant provisional crown on right central maxillary incisor. After complete lesion excision, the implant neck was carefully and gently debrided. Histological analysis confirmed the diagnosis of PGCG. The patient was then evaluated weekly for the first 3 weeks then monthly. No episodes of recurrence were identified. After 16 weeks of undisturbed healing, a soft tissue augmentation via tunnel technique was elected as the first treatment option to improve esthetics. Final implant restoration was delivered. Follow up at 22 months from biopsy excluded any recurrence of PGCG with stability of peri‐implant soft tissues. Conclusion Excisional biopsy, careful removal of irritating factors, monitoring, and connective tissue grafting can esthetically improve a malpositioned implant and showed no recurrence over a period of 22 months.

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“…Tiene una ligera inclinación por el sexo femenino, mostrando una mayor incidencia en la 4ta década de vida. Algunos autores describen su asociación a condiciones sistémicas como el hiperparatiroidismo (Smith et al, 1988;Guimarães et al, 2006;Choi et al, 2008;Boffano et al, 2013;Patil et al, 2014), siendo menos frecuente esta asociación que a las otras lesiones de células gigantes como el tumor pardo y el granuloma central de células gigantes. Clínicamente se observa como una masa pediculada, bien delimitada de color rojo oscuro y que puede sangrar a la palpación.…”

Section: Introductionunclassified

“…Puede dejar una impronta en el tejido óseo subyacente, pero no debiera ocasionar destrucción ósea. El tratamiento consiste en la extirpación quirúrgica de la lesión con legrado del hueso y periostio además de eliminar el factor irritante local (Smith et al; Choi et al; Boffano et al), logrando bajos niveles de recurrencia 5 -17,5 % (Boffano et al;Lester et al, 2014).…”

Section: Introductionunclassified

Granuloma Periférico de Células Gigantes e Hiperparatiroidismo. Presentación de un Caso

Alarcón-Arratia

Muñoz-Repetto²,

Schnettler

et al. 2019

Int. J. Odontostomat.

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ALARCÓN, A.; MUÑOZ, R. M.; SCHNETTLER, K. & ULLOA, M. C. Granuloma periférico de células gigantes e hiperparatiroidismo. presentación de un caso. Int. J. Odontostomat., 13(3):266-270, 2019. RESUMEN:Se presenta el caso de un paciente sexo femenino 31 años, insuficienciente renal crónica en hemodiálisis, hipertensa secundaria, consulta por aumento de volumen oral en relación a encía marginal vestibular izquierda, 6 meses de evolución. Al examen se observa aumento de volumen de 15 mm en relación a piezas. 3.6 y 3.7. Radiografía muestra compromiso periodontal pieza 3.7. Se realiza biopsia excisional y exodoncia pieza 3.7. Histopatología informa granuloma periférico de células gigantes. Se solicitan exámenes de laboratorio para estudio de hiperparatiroidismo (PTH elevada, calcemia fosfatemia normales). Evoluciona favorablemente. Sin signos de recidiva a los 3 meses. El diagnóstico histopatológico de lesión de células gigantes debe ser complementado con la clínica, exámenes de laboratorio e imagenología, el objetivo final es definir si tal diagnóstico corresponde a un tumor pardo, a un granuloma central de células gigantes o a un granuloma periférico de células gigantes. En la literatura los reportes de asociación entre granuloma periférico de células gigantes e hiperparatiroidismo son escasos. Este caso corresponde a granuloma periférico células gigantes, asociado a hipersecreción de paratohormona.PALABRAS CLAVE: granuloma periférico, células gigantes. hiperparatiroidismo. insuficiencia renal crónica.

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Review of Peripheral Giant Cell Granulomas

Cited by 15 publications

References 25 publications

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

Esthetic Management of Peripheral Giant Cell Granuloma Affecting a Dental Implant in the Esthetic Zone

Granuloma Periférico de Células Gigantes e Hiperparatiroidismo. Presentación de un Caso

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