Review of oxidative stress in relevance to uremia

Prakash, Ravi; Singapalli, Tanuja; Gokulnath,

doi:10.1016/j.cqn.2012.06.002

Cited by 7 publications

(9 citation statements)

References 53 publications

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“…Excess ROS can damage proteins, lipids, DNA, or carbohydrates by altering their structure. They most often form lipid peroxides, reacting with polyunsaturated fatty acids, which lead to cells damage [ 16 , 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Phytochemical, Antioxidant, and Hemostatic Studies of Extract and Four Fractions from Paulownia Clone in Vitro 112 Leaves in Human Plasma

et al. 2020

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Background: The Paulownia Clone in Vitro 112, known as oxytree or oxygen tree, is a hybrid clone of the species Paulownia elongata and Paulownia fortunei (Paulowniaceae). The oxytree is a fast-growing hybrid cultivar that can adapt to wide variations in edaphic and climate conditions. In this work, Paulownia Clone in Vitro 112 leaves were separated into an extract and four fractions (A–D) differing in chemical content in order to investigate their chemical content using LC-MS analysis. The extract and fractions were also evaluated for their anticoagulant and antioxidant properties in a human plasma in vitro. Results: The Paulownia leaf extract contained mainly phenolic compounds (e.g., verbascoside), small amounts of iridoids (e.g., aucubin or 7-hydroxytometoside) and triterpenoids (e.g., maslinic acid) were also detected. Our results indicate that the extract and fractions have different effects on oxidative stress in human plasma treated with H2O2/Fe in vitro, which could be attributed to differences in their chemical content. For example, the extract and all the fractions, at the two highest concentrations of 10 and 50 µg/mL, significantly inhibited the plasma lipid peroxidation induced by H2O2/Fe. Fractions C and D, at all tested concentrations (1–50 µg/mL) were also found to protect plasma proteins against H2O2/Fe-induced carbonylation. The positive effects of fraction C and D were dependent on the dose. Conclusions: The extract and all four fractions, but particularly fractions C and D, which are rich in phenolic compounds, are novel sources of antioxidants, with an inhibitory effect on oxidative stress in human plasma in vitro. Additionally, the antioxidant potential of fraction D may be associated with triterpenoids.

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Section: Discussionmentioning

confidence: 99%

Comparative Phytochemical, Antioxidant, and Hemostatic Studies of Extract and Four Fractions from Paulownia Clone in Vitro 112 Leaves in Human Plasma

et al. 2020

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“…Tissue damage is due to a number of enzyme and non-enzyme-mediated biochemical reactions which produce extremely reactive intermediate compoundsfree radicals. These free radicals are either endogenous and/or exogenous [1,2]. Major reactive oxygen species as divided into free radicals and reactive oxygen species are listed in the Table 1 [3].…”

Section: Introductionmentioning

confidence: 99%

Today’s oxidative stress markers

Czerska¹,

Mikołajewska²,

Zieliński³

et al. 2015

Med Pr

151

103

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Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously. Med Pr 2015;66(3):393-405Key words: isoprostanes, oxidative stress, oxidative stress markers, allantoin, metabolites of isoprostanes StreszczenieStres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów. Równowaga ta może być zakłócona w wyniku zwiększonego działania wolnych rodników lub spadku aktywności antyoksydacyjnej. Zaburzenia te mogą występować zarówno na poziomie komórkowym, jak i całego organizmu. Ponieważ stres oksydacyjny może być podłożem wielu zespołów chorobowych, niezwykle istotne jest znalezienie odpowiednich markerów, które mogą być wykorzystane do oceny jego poziomu in vivo. Stosowane od wielu lat markery -ocenę stężenia aldehyd dimalonowy (MDA) i substancji reagujących z kwasem tiobarbiturowym (thiobarbituric acid reactive substances -TBARS) -stopniowo uzupełnia się nowymi, takimi jak alantoina czy izoprostany (IzoP) wraz z ich metabolitami (IzoP-M). W niniejszej pracy skupiono się na zaprezentowaniu nowych, obiecujących markerów stresu oksydacyjnego (alantoina, IzoP, IzoP-M), ukazując korzyści wynikające z ich stosowania i prognozując dalsze kierunki badań nad ich zastosowaniem. Med. Pr. 2015;66(3):393-405 Słowa kluczowe: izoprostany, stres oksydacyjny, markery stresu oksydacyjnego, alantoina, metabolity izoprostanów Corresponding author / Autorka do korespondencji: Marta Czerska,

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“…12 A ingestão recomendada pelas diretrizes da EBPG (European Best Practice Guidelines) para saudáveis.…”

Section: Discussionunclassified

“…17,18 diminuídas, sendo sua suplementação a terapia antioxidante mais utilizada nesse caso. 12 ingestão de vitamina E consistem na suplementação diária 13 O estudo de Boaz et al 19 analisou os efeitos da suplementação observou melhora no estresse oxidativo e redução na incidência de doenças cardiovasculares nos pacientes que receberam a vitamina E. 19 No presente estudo, encontrou-se uma média e de 4,32 mg no grupo masculino, com todos os pacientes apresentando inadequação de consumo, demonstrando que provavelmente os sistemas antioxidantes relacionados à vitamina E estão debilitados nesses grupos.…”

Section: Discussionunclassified

Inadequação do consumo alimentar de nutrientes antioxidantes em nefropatas crônicos em hemodiálise

Santos¹,

Barroso

Araújo³

et al. 2017

Rev. Med. UFC

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INTRODUÇÃO: o consumo de nutrientes antioxidantes por pacientes em hemodiálise é importante, pois a doença renal pode desencadear desequilíbrio oxidativo decorrente da intensa produção de espécies reativas, falhas nos sistemas antioxidantes e retenção do soluto oxidado. OBJETIVO: avaliar a adequação do consumo alimentar de nutrientes antioxidantes por pacientes renais crônicos em hemodiálise. MÉTODOS: o estudo foi desenvolvido com pacientes em tratamento de hemodiálise, afiliados a duas clínicas especializadas em Fortaleza, Ceará, Brasil. Os dados foram coletados por meio de três recordatórios de 24h e tabulados no programa Excel 2007®. Foram realizadas análises qualitativa e quantitativa da ingestão de selênio, zinco, vitamina A, vitamina C e vitamina E. O estudo incluiu 26 homens e 18 mulheres entre 19 e 83 anos de idade. RESULTADOS: encontraram-se médias de ingestão abaixo da EAR (Estimated Average Requeriment) de zinco, vitamina A, C e E e prevalências de risco de inadequação superior a 50% para todos os micronutrientes analisados, exceto o selênio. A ingestão de vitamina E foi inferior a EAR em 100% dos pacientes. CONCLUSÃO: os pacientes renais crônicos em hemodiálise se encontravam com ingestão inadequada de micronutrientes antioxidantes, contribuindo para o aumento do estresse oxidativo.

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Review of oxidative stress in relevance to uremia

Cited by 7 publications

References 53 publications

Comparative Phytochemical, Antioxidant, and Hemostatic Studies of Extract and Four Fractions from Paulownia Clone in Vitro 112 Leaves in Human Plasma

Comparative Phytochemical, Antioxidant, and Hemostatic Studies of Extract and Four Fractions from Paulownia Clone in Vitro 112 Leaves in Human Plasma

Today’s oxidative stress markers

Inadequação do consumo alimentar de nutrientes antioxidantes em nefropatas crônicos em hemodiálise

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