Review of Outcome Measurement Instruments in Alzheimer's Disease Drug Trials: Psychometric Properties of Functional and Quality of Life Scales

Demers, Louise; Oremus, Mark; Perrault, Anne; Champoux, Nathalie; Wolfson, Christina

doi:10.1177/089198870001300402

Cited by 45 publications

(33 citation statements)

References 35 publications

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“…[112][113][114][115][116] The structure, administration method and target population for each measure are described here and summarised in 89 consists of 31 items covering six domains (positive affect, ability for communication, negative affect/negative action, spontaneity/activity, restlessness and attachment to others). The questionnaire is reported by a proxy (either nursing staff or a family carer).…”

Section: Critical Review Of Measures Of Hrqol In Dementiamentioning

confidence: 99%

Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology

Smith¹,

Lamping²,

Banerjee

et al. 2005

Health Technol Assess

512

520

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Section: Critical Review Of Measures Of Hrqol In Dementiamentioning

confidence: 99%

Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology

Smith¹,

Lamping²,

Banerjee

et al. 2005

Health Technol Assess

512

520

View full text Add to dashboard Cite

show abstract

“…However, proxy reports may be biased by personal beliefs regarding what constitutes QOL from the perspective of a person who is cognitively intact. Therefore, a scale based on direct observation of behavior and affect might have much to offer if it were sensitive to change [10].…”

Section: Introductionmentioning

confidence: 99%

Responsiveness of the Quality of Life in Late-Stage Dementia Scale to Psychotropic Drug Treatment in Late-Stage Dementia

Martin-Cook

Hynan²,

Rice-Koch

et al. 2005

Dement Geriatr Cogn Disord

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Background: We report on the responsiveness of a previously validated quality-of-life scale, the Quality of Life in Late-Stage Dementia scale (QUALID), as an outcome measure in a clinical trial of two psychotropic medications. Methods: Secondary analyses were conducted comparing outcome measures used in a randomized double-blind trial of two antipsychotics (olanzapine and risperidone) for the treatment of dementia-related behavioral symptoms. The QUALID was completed for 31 of the patients in addition to several measures of behavior-related dementia symptoms including the Neuropsychiatric Inventory, the Withdrawn Behavior subscale of the Multidimensional Observation Scale for Elderly Subjects, the Mini-Mental State Examination, and the Clinical Global Impression. Measures of safety and adverse effects included the Simpson-Angus Scale and records of specific adverse events. Results: A significant positive relationship was found between QUALID score and improvement in behavioral symptoms, and a negative association was found with adverse medication effects. Conclusions: The QUALID was sensitive to both the treatment effects and the adverse effects of medication in this sample of patients.

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“…Furthermore, the perceived difficulties of using everyday technology among people with cognitive impairment must be taken into consideration when evaluating function (Rosenberg et al, 2009). However, during the literature research no instrument was found to include all relevant ADL areas and existing instruments lacked validity and reliability (Sikkes et al, 2009, Demers et al, 2000.…”

Section: Assessment Instruments and Methodsmentioning

confidence: 99%

Cognitive impairment and its consequences in everyday life

Johansson

2015

Linköping University Medical Dissertations

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Review of Outcome Measurement Instruments in Alzheimer's Disease Drug Trials: Psychometric Properties of Functional and Quality of Life Scales

Cited by 45 publications

References 35 publications

Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology

Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology

Responsiveness of the Quality of Life in Late-Stage Dementia Scale to Psychotropic Drug Treatment in Late-Stage Dementia

Cognitive impairment and its consequences in everyday life

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