Review of Outcome Measurement Instruments in Alzheimer's Disease Drug Trials: Psychometric Properties of Behavior and Mood Scales

Perrault, Anne; Oremus, Mark; Demers, Louise; Vida, Stephen; Wolfson, Christina

doi:10.1177/089198870001300403

Cited by 43 publications

(54 citation statements)

References 68 publications

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“…Later versions of the inventory, used in studies not reviewed, were translated into several languages. While the Neuropsychiatric Inventory is popular worldwide it has been criticized for not being responsive to change and score distributions (Perrault et al, 2000). Two of the 4 studies using the Neuropsychiatric Inventory, both conducted by Raglio et al (2008Raglio et al ( , 2010, showed significant decreases in anxiety scores: 3.34-2.93 (p = 0.002) and 2.63-0.93 (p < 0.001) (Raglio et al, 2008(Raglio et al, , 2010.…”

Section: Reliability and Validity Of The Measuresmentioning

confidence: 99%

Group music interventions for dementia-associated anxiety: A systematic review

Ing-Randolph

Phillips

Williams

2015

International Journal of Nursing Studies

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Section: Reliability and Validity Of The Measuresmentioning

confidence: 99%

Group music interventions for dementia-associated anxiety: A systematic review

Ing-Randolph

Phillips

Williams

2015

International Journal of Nursing Studies

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“…0.79 for frequency and 0.86 for severity) and good inter-rater reliability had been established (e.g. 84.1%À100% crude agreement) (Perrault et al, 2000). Folstein, & McHugh, 1975).…”

Section: Data Collectionmentioning

confidence: 99%

Factors influencing the person–carer relationship in people with anxiety and dementia

Spector

Orrell

Charlesworth

et al. 2015

Aging & Mental Health

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“…Moreover, patients undergoing cholinergic drug treatments have shown changes in mood (28). We therefore examined psychiatric-like behaviors in VAChT Six3-Cre-flox/flox mice.…”

Section: Forebrain Cholinergic Tone Is Involved In Spontaneous Locomomentioning

confidence: 99%

Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation

Martyn¹,

Jaeger

Magalhães³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Basal forebrain cholinergic neurons, which innervate the hippocampus and cortex, have been implicated in many forms of cognitive function. Immunolesion-based methods in animal models have been widely used to study the role of acetylcholine (ACh) neurotransmission in these processes, with variable results. Cholinergic neurons have been shown to release both glutamate and ACh, making it difficult to deduce the specific contribution of each neurotransmitter on cognition when neurons are eliminated. Understanding the precise roles of ACh in learning and memory is critical because drugs that preserve ACh are used as treatment for cognitive deficits. It is therefore important to define which cholinergic-dependent behaviors could be improved pharmacologically. Here we investigate the contributions of forebrain ACh on hippocampal synaptic plasticity and cognitive behavior by selective elimination of the vesicular ACh transporter, which interferes with synaptic storage and release of ACh. We show that elimination of vesicular ACh transporter in the hippocampus results in deficits in long-term potentiation and causes selective deficits in spatial memory. Moreover, decreased cholinergic tone in the forebrain is linked to hyperactivity, without changes in anxiety or depression-related behavior. These data uncover the specific contribution of forebrain cholinergic tone for synaptic plasticity and behavior. Moreover, these experiments define specific cognitive functions that could be targeted by cholinergic replacement therapy.Alzheimer's disease | Morris water maze | synaptic vesicle | Barnes maze T he mechanisms that underlie the formation of hippocampaldependent spatial memory have been broadly explored (1). However, the neurochemical basis underlying changes in the strength of synaptic connections necessary for memories to persist is still not precisely understood. In the case of the hippocampus, mechanisms for memory processing include mRNA-dependent (2) and mammalian target of rapamycin (mTOR)-mediated protein synthesis (3) as well as a sequence of biochemical events shared with or closely similar to that of long-term potentiation (LTP) (2). Indeed, the consolidation of two different aversive tasks (4) and of spatial recognition memory (5) is accompanied by LTP of the CA3-CA1 synapse and can be occluded by a preceding LTP.The basal forebrain cholinergic system, which innervates the hippocampus and cortex, has been suggested to modulate LTP in the hippocampus (6-9) and has been implicated in many forms of behavior (10). In addition, spatial memory has also been suggested to depend on cholinergic activity (10), although there are numerous controversies surrounding which behaviors acetylcholine (ACh) regulates (11, 12). Moreover, in few studies cholinergic denervation did not affect expression of LTP (13). Understanding the precise roles of ACh in learning and memory is of importance because in different types of dementia cholinergic function is decreased (14), and manipulations that boost ACh levels at synapses are used a...

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Review of Outcome Measurement Instruments in Alzheimer's Disease Drug Trials: Psychometric Properties of Behavior and Mood Scales

Cited by 43 publications

References 68 publications

Group music interventions for dementia-associated anxiety: A systematic review

Group music interventions for dementia-associated anxiety: A systematic review

Factors influencing the person–carer relationship in people with anxiety and dementia

Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation

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