Review of orbital exenterations in Korle-Bu Teaching Hospital

Ackuaku-Dogbe, E

doi:10.4314/gmj.v45i2.68927

Cited by 13 publications

(10 citation statements)

References 10 publications

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“…In an other study with 25 cases, SCC rate was reported as 76%. 9 In our study eyelid BCC (43.75%) were the most common neoplasms leading to exenteration.…”

Section: Discussionmentioning

confidence: 51%

Orbital Exenterations: Our experience at Ankara Oncology Research And Training Hospital.

Duman¹

2013

UHOD

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The aim of this study is to review our 5 year experience with orbital exenterations and to evaluate the demographic and clinical features of patients, indications and outcomes. Between January 2008 and December 2012, 16 patients who underwent orbital exenteration were included in the study. Most of the lesions originated from eyelid (n= 14) and remaining 2 lesions originated from orbit. Histopathological examination of the lesions were consistent with basal cell carcinoma (n= 7), squamous cell carcinoma (n=5), sebaceous carcinoma (n= 2), choroidal melanoma (n= 1) and adenoid cystic carcinoma (n= 1). Secondary orbital tumours are the major indication for orbital exenteration. Aggressive removal of primary tumours can reduce the frequency of this disfiguring procedure.Keywords: Orbital exenteration, Orbital tumour, Squamous cell carcinoma, Basal cell carcinoma, Eyelid sebaceous carcinoma ÖZET Orbital Ekzenterasyonlar: Ankara Onkoloji Araflt›rma ve E¤itim Hastanesindeki DeneyimlerimizBu çal›flman›n amac› orbital ekzenterasyonlarla ilgili befl y›ll›k deneyimlerimlerimizi gözden geçirmek, hastalar›n demografik ve klinik özelliklerini, endikasyonlar›n› ve sonuçlar›n› de¤erlendirmektir. Ocak 2008 ile Aral›k 2012 aras›nda, orbital ekzenterasyon yap›lan 16 hasta çal›flmaya al›nd›. Lezyonlar›n ço¤u göz kapa¤›ndan kaynaklanmakta, geriye kalan 2 lezyon ise orbitadan (% 12.5) kaynaklanmakta idi. Lezyonlar›n histopatolojik incelemesi bazal hücreli karsinom (n= 7), skuamöz hücreli karsinom (n= 5), sebase karsinom (n= 25), koroidal melanom (n= 1) ve adenoid kistik karsinom (n= 1) ile uyumlu idi. Ekzenterasyonlar›n en önemli endikasyonu sekonder orbita tümörleri idi. Primer tümörlerin agresif tedavisi kötü görünüme sebep olan bu prosedür s›kl›¤›n› azaltabilir.Anahtar Kelimeler: Orbital ekzenterasyon, Orbital tümör, Yass› hücreli karsinom, Bazal hücreli karsinom, Göz kapa¤›n›n sebase bez karsinomu ULUSLARARASı HEMATOLOJI-ONKOLOJI DERGISI ARTICLE

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“…In an other study with 25 cases, SCC rate was reported as 76%. 9 In our study eyelid BCC (43.75%) were the most common neoplasms leading to exenteration.…”

Section: Discussionmentioning

confidence: 51%

Orbital Exenterations: Our experience at Ankara Oncology Research And Training Hospital.

Duman¹

2013

UHOD

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“…It has been previously shown, as in this research, that larger tumours such as those seen in patients with HIV infection tend to be invasive, need more extensive surgery, and frequently recur after surgery [ 4 , 8 , 14 , 15 ]. This raises the question of what adequate initial surgery should be performed and what criteria to use to initiate adjuvant radiotherapy or other therapies following surgical intervention [ 9 , 14 ].…”

Section: Discussionmentioning

confidence: 75%

Evaluation of the radiotherapy management of ocular surface squamous neoplasia in a high HIV prevalence setting- a retrospective review

Ndlovu

Ndarukwa

Kadzatsa

et al. 2016

Infect Agents Cancer

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BackgroundThis article evaluates a single institute’s radiotherapy management of OSSN, a previously regarded as rare malignancy, for possible future development of strategies to clearly define the role of adjuvant radiotherapy in improving treatment outcomes.Materials and methodsA retrospective review of 153 patients treated from January 2003 to December 2009.ResultsThere was no difference in OSSN prevalence by gender (male to female ratio 1.07). Of 80/153 patients tested 79 (98.8 %) were HIV positive. Most patients (62.9 %) had prior orbital exenteration. Moderately and poorly differentiated grade (82.3 %) was associated with significantly higher stage and incidence of positive regional lymph nodes. External beam therapy dose mostly used was 60Gy in 30 fractions at 200 cGy per fraction in 5 fractions per week (34.8 %). 90Strontium therapy was given to 13.5 % (60Gy in 6 fractions at 10Gy per fraction weekly). Favourable response (complete and partial) was seen in about 80 % of patients associated with higher total doses. Regional lymph node positivity was associated with poorer outcome.ConclusionAdjuvant radiotherapy could have an important role in the management of patients presenting with locally advanced OSSN who are mostly HIV positive in developing countries. Prospective studies to evaluate the role of radiotherapy with or without chemotherapy in the management of OSSN in these settings are warranted.

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“…Similar results were found in Ghana by Ackuaku-Dogbe. 1 Several risk factors for the development of this ocular surface neoplasm including solar radiation, melanoderma, and high prevalence of HIV 12 are present in Cameroon. Squamous cell carcinoma is highly aggressive, with a higher incidence of corneal, sclera, and orbital invasion when associated with HIV infection.…”

Section: Discussionmentioning

confidence: 99%

“…Several different methods for orbital reconstruction have been described, including the use of midline forehead flaps, temporalis muscle transposition, dermal grafts, dermis fat grafts, and split skin grafts. 1 , 18 Although primary reconstruction provides a better postoperative esthetic appearance, early recurrences can be missed. In our study, no primary orbital reconstruction was performed.…”

Section: Discussionmentioning

confidence: 99%

“…Orbital exenteration (OE) is a disfiguring procedure that typically involves removal of the entire contents of the orbit, including the periorbital, appendages, eyelids, and sometimes a varying amount of surrounding skin and bone. 1 This procedure is indicated for the treatment of potential life-threatening malignancies arising from the orbit, para nasal sinuses, or periocular skin. 2 , 3 Orbital malignancy can also be a metastasis of other cancers.…”

Section: Introductionmentioning

confidence: 99%

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Orbital exenteration in immunodeficiency virus-infected patients

Kagmeni

Bilong

Arlette

et al. 2016

OPTH

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BackgroundOrbital exenteration (OE) is a disfiguring procedure most commonly performed for locally advanced and potentially life-threatening periorbital malignancies.MethodsWe retrospectively reviewed records of 11 consecutive HIV patients who underwent OE for invasive orbital malignancy at our institution from January 2005 to December 2015. Patient demographic and clinic data and histopathology of the tumor were analyzed.ResultsThere were eight (72.72%) female and three (27.28%) male participants ranging in age from 31 to 52 years with an mean of 39.4 years. Nine patients had been known to be HIV-positive for at least 2 years, and HIV-positive status was revealed at presentation for two patients. The mean CD4 cell count was 154.4 cells/mm3. Histopathological examination showed invasive orbital squamous cell carcinomas in nine patients (81.81%), achromic orbital melanoma in one patient (9.09%), and adenoid cystic carcinoma in one patient (9.09%). None of the patients underwent primary orbital reconstruction. The mean follow-up time was 3.4 months. Only one patient who underwent adjuvant radiotherapy was seen after 12 months.ConclusionOculo-orbital malignancies are very aggressive in HIV-positive individuals, especially in untreated patients. Routine screening for suspected ocular surface lesions and early surgical removal of all these lesions could help to avoid the need to perform the radical and disfiguring OE procedure.

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Review of orbital exenterations in Korle-Bu Teaching Hospital

Cited by 13 publications

References 10 publications

Orbital Exenterations: Our experience at Ankara Oncology Research And Training Hospital.

Orbital Exenterations: Our experience at Ankara Oncology Research And Training Hospital.

Evaluation of the radiotherapy management of ocular surface squamous neoplasia in a high HIV prevalence setting- a retrospective review

Orbital exenteration in immunodeficiency virus-infected patients

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