Review of multi-modality imaging update and diagnostic work up of Takotsubo cardiomyopathy

Priya, Sarv; Nagpal, Prashant; Aggarwal, Tanya; MD, None James Huynh,; Khandelwal, Kanika; Khandelwal, Ashish

doi:10.1016/j.clinimag.2021.08.027

Cited by 5 publications

(22 citation statements)

References 90 publications

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Section: Diagnostic Workup and Findings In Takotsubo Cardiomyopathymentioning

confidence: 99%

“…In TTC patients, the levels of cardiac enzymes, creatine kinase (CK), CK-MB, and cardiac troponin, and NT-proBNP are increased [13,26]. In addition, the levels of serum catecholamines, neuropeptide-Y, and serotonin are also increased [26]. ECG evaluation in these patients usually shows ST elevation or depression, inversion of the T-wave, and prolongation of the QT-interval [13,26].…”

Section: Diagnostic Workup and Findings In Takotsubo Cardiomyopathymentioning

confidence: 99%

“…In addition, the levels of serum catecholamines, neuropeptide-Y, and serotonin are also increased [26]. ECG evaluation in these patients usually shows ST elevation or depression, inversion of the T-wave, and prolongation of the QT-interval [13,26]. On echocardiography, which is the first-line imaging modality for TTC evaluation, LV dysfunction, ballooning (mostly apical), wall-motion abnormalities, and abnormalities of the valves are detected.…”

Section: Diagnostic Workup and Findings In Takotsubo Cardiomyopathymentioning

confidence: 99%

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COVID-19 vaccines-associated Takotsubo cardiomyopathy: A narrative review

2024

Infez Med

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Takotsubo cardiomyopathy (TTC) is a severe, acute, reversible, and self-limited cardiac dysfunction. It usually affects postmenopausal women and is mostly triggered by physical or emotional stressors. Following the COVID-19 pandemic, millions of doses of different types of COVID-19 vaccines are being administered globally. There have been reports of different cardiac complications after receiving COVID-19 vaccines. To our knowledge, there have been 16 reported cases of COVID-19 vaccination-associated TTC. In this study, we first provide a brief overview of TTC and then an overview of selected reported TTC cases following COVID-19 vaccinations. It is crucial to highlight that the occurrence of TTC after vaccination does not establish a direct cause-and-effect relationship between immunization and TTC. Further investigations are necessary to examine any potential association between COVID-19 vaccines and the incidence of TTC. Additionally, the benefits of receiving COVID-19 vaccines significantly outweigh the potential risks of developing adverse events.

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Section: Diagnostic Workup and Findings In Takotsubo Cardiomyopathymentioning

confidence: 99%

Section: Diagnostic Workup and Findings In Takotsubo Cardiomyopathymentioning

confidence: 99%

Section: Diagnostic Workup and Findings In Takotsubo Cardiomyopathymentioning

confidence: 99%

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COVID-19 vaccines-associated Takotsubo cardiomyopathy: A narrative review

2024

Infez Med

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“…VTAs are often detected on the left ventricle (LV) but can also be seen on the right ventricle (RV). The etiopathogenesis of VTAs may include myocardial infarction (MI), myocarditis, Chagas disease, and trauma, 1 , 3 , 4 their medical management may consist of anticoagulation to prevent thromboembolism and afterload reduction. Surgical treatment may be considered for large VTAs, a VTA with an increased size during follow-up, angina, rupture, or heart failure.…”

Section: Ventricular Outpouchingsmentioning

confidence: 99%

Cross-sectional imaging findings of cardiac outpouchings

Ufuk¹,

Hazırolan²

2023

dir

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A cardiac outpouching (CO) is a protrusion in a heart chamber's internal anatomical lining. Most COs are clinically insignificant, but some are of vital importance, requiring immediate surgery. Cross-sectional imaging findings of COs, such as location, morphology, size, and accompanying wall motion abnormalities, play an essential role in determining the correct diagnosis and appropriate clinical management. Therefore, radiologists should be familiar with them. This article reviews the key cross-sectional imaging findings and differential diagnoses of COs.

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“…The reaction to stressors depends on individual factors influencing both catecholamine production and myocyte and microvascular response to sympathetic stimulation [24], with estrogen deficiency, genetic factors, and neurologic and psychiatric disorders being predisposing factors to mental and physical triggers [25][26][27][28][29]. Despite the clinical presentation usually mimicking ACS [30], with patients often presenting with chest pain, followed by dyspnea and syncope [31], having electrocardiographic abnormalities (ST-segment elevation, ST-segment depression, T-wave negative conversion, and QT prolongation) [32] and showing a mild elevation of myocardionecrosis enzyme levels, as well as the marked elevation of brain natriuretic peptide (BNP) and N-terminal pro-BNP [33][34][35][36], TTC is formally considered a benign self-limiting state presenting a favorable prognosis [37] and it is generally characterized by a temporary impairment with complete recovery within 3 weeks. However, complications including lethal ventricular arrhythmia, pump failure, outflow tract obstruction, cardiac rupture, and systemic embolization may occur in the acute phase and cause morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy

De Feo,

Conte,

Frantellizzi

et al. 2024

Applied Sciences

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Background: In addition to the typical form resembling the classical Japanese octopus trap, atypical variants of Takotsubo cardiomyopathy (TTC) sparing the left ventricular apex have emerged over the years. The aim of this systematic review is to provide a comprehensive overview of the cardiac nuclear imaging findings in atypical variants. Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The literature research was carried out online on the Pubmed, Scopus, Central (Cochrane Library), and Web Of Science databases. Results: A total of 14 articles were ultimately selected. Myocardial perfusion scintigraphy was performed in nine studies, followed by 123I-mIBG scintigraphy, 123I-BMIPP scintigraphy, and 18F-FDG PET. In seven cases, a single cardiac nuclear imaging technique was performed, while in the remaining five and two cases, two and three different imaging modalities were, respectively, used. The most common atypical variant of our selection was the midventricular form, followed by reverse/inverted/basal TTC, with only a single case reported of a focal pattern. Conclusions: As the reason why TTC variants occur is still not clear, a deeper understanding of the current knowledge could be the basis for providing more insights into this fascinating disorder and its uncommon manifestations.

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Review of multi-modality imaging update and diagnostic work up of Takotsubo cardiomyopathy

Cited by 5 publications

References 90 publications

COVID-19 vaccines-associated Takotsubo cardiomyopathy: A narrative review

COVID-19 vaccines-associated Takotsubo cardiomyopathy: A narrative review

Cross-sectional imaging findings of cardiac outpouchings

Cardiac Nuclear Imaging Findings in Atypical Variants of Takotsubo Cardiomyopathy

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