Review of Mouse Models Applied to the Study of Asthma

Garcia, Fabien; Marcos-Vadillo, Elena

doi:10.1007/978-1-4939-3652-6_15

Cited by 15 publications

(16 citation statements)

References 54 publications

(50 reference statements)

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“…Multiple in vivo animal models that reflect the pathogenesis of human lung diseases have been developed in the past. As a detailed discussion about animal models representing lung disorders would far exceed the scope of this review, we therefore refer the reader to a number of excellent reviews for further reading [156][157][158][159][160][161][162]. In particular, studies on mesenchymal cells, which are physiologically embedded within the ECM, may profit from in vitro, in vivo or ex vivo models that closely resemble the structure and biomechanics of pulmonary interstitial ECM [163][164][165].…”

Section: Ecm Model Systemsmentioning

confidence: 99%

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

et al. 2017

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The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and provides mechanical stability and elastic recoil, which are essential for physiological lung function. Biochemical and biomechanical signals initiated by the ECM direct cellular function and differentiation, and thus play a decisive role in lung development, tissue remodelling processes and maintenance of adult homeostasis. Recent proteomic studies have demonstrated that at least 150 different ECM proteins, glycosaminoglycans and modifying enzymes are expressed in the lung, and these assemble into intricate composite biomaterials. These highly insoluble assemblies of interacting ECM proteins and their glycan modifications can act as a solid phase-binding interface for hundreds of secreted proteins, which creates an information-rich signalling template for cell function and differentiation. Dynamic changes within the ECM that occur upon injury or with ageing are associated with several chronic lung diseases. In this review, we summarise the available data about the structure and function of the pulmonary ECM, and highlight changes that occur in idiopathic pulmonary fibrosis (IPF), pulmonary arterial hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma and lung cancer. We discuss potential mechanisms of ECM remodelling and modification, which we believe are relevant for future diagnosis and treatment of chronic lung disease.

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Section: Ecm Model Systemsmentioning

confidence: 99%

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

et al. 2017

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“…Such more flexible model systems allow deeper and more precise investigations of the mechanisms underlying the development of different phenotypes and a much better characterization of the orchestration of different regulatory and effector T cell subsets in dependence of allergen administration on a continuum between Th2 and Th1/Th17-driven inflammation. In addition, these mouse models mimic the natural situation more closely by using common allergens and a potential natural route of sensitization and thus became helpful for understanding the diverse clinical phenotypes of allergic and non-allergic as well as mild and severe asthma ( 57 , 58 ). By switching between different effector T cell responses in these experimental set-ups substantial knowledge is currently added to our understanding of clinical manifestations in asthma.…”

Section: Challenges From the Clinics And Lessons From Animal Models –mentioning

confidence: 99%

The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate

2021

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During its 30 years history, the Hygiene Hypothesis has shown itself to be adaptable whenever it has been challenged by new scientific developments and this is a still a continuously ongoing process. In this regard, the mini review aims to discuss some selected new developments in relation to their impact on further fine-tuning and expansion of the Hygiene Hypothesis. This will include the role of recently discovered classes of innate and adaptive immune cells that challenges the old Th1/Th2 paradigm, the applicability of the Hygiene Hypothesis to newly identified allergy/asthma phenotypes with diverse underlying pathomechanistic endotypes, and the increasing knowledge derived from epigenetic studies that leads to better understanding of mechanisms involved in the translation of environmental impacts on biological systems. Further, we discuss in brief the expansion of the Hygiene Hypothesis to other disease areas like psychiatric disorders and cancer and conclude that the continuously developing Hygiene Hypothesis may provide a more generalized explanation for health burden in highly industrialized countries also relation to global changes.

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“…Mouse models of asthma, or allergic airways dysfunction, have been used extensively to elucidate basic mechanisms of proinflammatory signaling leading to cellular recruitment and remodeling of the respiratory tract (6). These models routinely involve one or two intraperitoneal sensitizations with antigen in complex with adjuvant (typically alum) followed by multiple, sequential challenges directly to the respiratory tract.…”

mentioning

confidence: 99%