Review of migraine incidence and management in obstetrics and gynaecology

Tanos, Vasilios; Raad, Elissa Abi; Berry, Kelsey Elizabeth; Toney, Zara Abigail

doi:10.1016/j.ejogrb.2019.07.021

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…With an estimated global prevalence of 14.7%, migraine, on the other hand, is the most disabling neurologic disorder and the third most common illness worldwide [3,4]. Like endometriosis, women in their reproductive and most productive years are more commonly affected with migraine [5,6]. A typical migraine presents with a recurrent, unilateral and episodic headache of moderate to severe intensity [7].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, Danazol (a synthetic androgen for managing endometriosis) has been reported to reduce the frequency of migraine attacks [25]. In addition to their shared similarities and risk factors, the comorbidity (co-occurrence of two or more conditions in the same individual) of endometriosis with migraine has been consistently reported by observational epidemiological studies [5,6,18,[26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

Adewuyi

Sapkota

Auta

et al. 2020

Genes

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Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we examined the relationship between endometriosis and migraine using genome-wide association study (GWAS) data. Single nucleotide polymorphism (SNP) effect concordance analysis found a significant concordance of SNP risk effects across endometriosis and migraine GWAS. Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation (rG = 0.38, P = 2.30 × 10−25) between endometriosis and migraine. A meta-analysis of endometriosis and migraine GWAS data did not reveal novel genome-wide significant SNPs, and Mendelian randomisation analysis found no evidence for a causal relationship between the two traits. However, gene-based analyses identified two novel loci for migraine. Also, we found significant enrichment of genes nominally associated (Pgene < 0.05) with both traits (Pbinomial-test = 9.83 × 10−6). Combining gene-based p-values across endometriosis and migraine, three genes, two (TRIM32 and SLC35G6) of which are at novel loci, were genome-wide significant. Genes having Pgene < 0.1 for both endometriosis and migraine (Pbinomial-test = 1.85 ×10−°3) were significantly enriched for biological pathways, including interleukin-1 receptor binding, focal adhesion-PI3K-Akt-mTOR-signaling, MAPK and TNF-α signalling. Our findings further confirm the comorbidity of endometriosis and migraine and indicate a non-causal relationship between the two traits, with shared genetically-controlled biological mechanisms underlying the co-occurrence of the two disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

Adewuyi

Sapkota

Auta

et al. 2020

Genes

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“…A migraine itself rather than its treatment is also associated with an increased risk of adverse perinatal outcomes. A systematic study confirmed that migraineurs have an increased risk of preterm birth and low birth weight baby by 1.72-fold and 1.8-fold respectively, compared to nonmigraineurs [3]. However, there is a hypothesis that low birth weight may be the consequence of comorbid conditions rather than the migraine itself [23].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is a hypothesis that low birth weight may be the consequence of comorbid conditions rather than the migraine itself [23]. Pregnant migraineurs also have an increased risk of preeclampsia, need for the Caesarean section, gestational hypertension [3], placental abruption [24], and even stroke [25]. Unfortunately, there is no data reporting a link between new-onset migraine and adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…According to the latest study of the Global Burden of Disease, a migraine is the second highest cause of years lived with disability for both genders and the first among young women [1]. Among all headache disorders, a migraine, followed by a tension-type headache (TTH), has the highest prevalence during gestation [2], and it is estimated to be around 20% [3].…”

Section: Introductionmentioning

confidence: 99%

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De novo migraine with aura in the third trimester of pregnancy: a case report and literature review

Paškevičiūtė

Bužinskienė

Ryliškienė

2021

AML

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Background: Among all headache disorders, migraine has the highest prevalence during gestation. The majority of migraineurs experience improvement during pregnancy, but a few may experience migraine for the first time. This poses a diagnostic challenge in the differential diagnosis between primary and life-threatening secondary headache disorders. Because pregnancy itself is an independent risk factor for secondary headache disorders, it is mandatory to exclude these conditions in order to diagnose migraine. There is a large body of literature about pre-existing migraine course during pregnancy and its link with adverse pregnancy outcomes, but there are no studies examining these aspects among women with new-onset migraine during pregnancy.Case report. A 31-year-old female at 33 weeks of gestation (gravida 2, para 2) was referred to the neurologist eds disturbances, which were followed by pressing severe headache, rated as 8 out of 10 on a numeric rating scale and accompanied by dizziness. The headache lasted for one day, and dizziness continued to the following day. The patient was investigated for a secondary headache disorder, but laboratory and neuroimaging results were unremarkable. A migraine with aura was diagnosed. The patient was advised to keep a consistent sleep schedule, maintain regular low physical activity, eat regularly and take magnesium supplementation. The patient was informed about a safe treatment approach in case of an acute attack. At 40 weeks of gestation the patient delivered female newborn, weighing 3750g, with Apgar scores of 8 and 9 (due to a nuchal cord). The postpartum period was uneventful. During the subsequent 4 years, the patient did not experience any recurrent migraine attacks and had no pregnancies.Conclusion. In order to diagnose a migraine during pregnancy, exclusion of secondary headache disorders is mandatory. Pregnant migraineur should be regularly monitored for adverse birth outcomes. It is essential to educate patients, provide information about the safe treatment of migraine attacks, and explain nonpharmacological prevention and supplementation benefits.

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A systematic review and meta-analyses on the prevalence of pregnancy outcomes in migraine treated patients: a contribution from the IMI2 ConcePTION project

et al. 2021

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Review of migraine incidence and management in obstetrics and gynaecology

Cited by 19 publications

References 31 publications

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity

De novo migraine with aura in the third trimester of pregnancy: a case report and literature review

A systematic review and meta-analyses on the prevalence of pregnancy outcomes in migraine treated patients: a contribution from the IMI2 ConcePTION project

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