Review of Metal, Carbon and Polymer Nanoparticles for Infrared Photothermal Therapy

Graham, Elizabeth G.; MacNeill, Christopher M.; Levi‐Polyachenko, Nicole

doi:10.1142/s1793984413300021

Cited by 30 publications

(15 citation statements)

References 230 publications

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“…Nowadays, nanomaterials are more and more exploited to enhance sensing performances due to the possibility to immobilize more bioreceptor units at reduced volumes and even to act themselves as transduction elements. Nanoparticles, including metallic ones (Baioni et al, 2008;Hrapovic et al, 2004;Salimi et al, 2009;Su et al, 2003), polymer ones (Graham et al, 2013;Kumari et al, 2010;Pu et al, 2014;van Vlerken and Amiji, 2006), magnetic ones (Ito et al, 2005;McBain et al, 2008;Reiss and Hutten, 2005), have all found great usage in biomedical applications.…”

Section: Molecular Targets and Biomarker Sensingmentioning

confidence: 99%

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

Zhang

Wang

Khalili

et al. 2016

OMICS: A Journal of Integrative Biology

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We live in exciting times for a new generation of biomarkers being enabled by advances in the design and use of biomaterials for medical and clinical applications, from nano-to macro-materials, and protein to tissue. Key challenges arise, however, due to both scientific complexity and compatibility of the interface of biology and engineered materials. The linking of mechanisms across scales by using a materials science approach to provide structure-process-property relations characterizes the emerging field of 'materiomics,' which offers enormous promise to provide the hitherto missing tools for biomaterial development for clinical diagnostics and the next generation biomarker applications towards personal health monitoring. Put in other words, the emerging field of materiomics represents an essentially systematic approach to the investigation of biological material systems, integrating natural functions and processes with traditional materials science perspectives. Here we outline how materiomics provides a game-changing technology platform for disruptive innovation in biomaterial science to enable the design of tailored and functional biomaterials-particularly, the design and screening of DNA aptamers for targeting biomarkers related to oral diseases and oral health monitoring. Rigorous and complementary computational modeling and experimental techniques will provide an efficient means to develop new clinical technologies in silico, greatly accelerating the translation of materiomics-driven oral health diagnostics from concept to practice in the clinic.

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Section: Molecular Targets and Biomarker Sensingmentioning

confidence: 99%

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

Zhang

Wang

Khalili

et al. 2016

OMICS: A Journal of Integrative Biology

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“…Ablative hyperthermia represents a therapy capable of achieving necrotic cell death through elevated temperature (T > 45 °C), but current methods of ablation cannot safely address diffuse disease 10 – 12 . A method of targeting ablative hyperthermia to diffuse micrometastases is through the use of photothermal nanoparticles, which are capable of producing heat under photoexcitation 13 , 14 . Such nanoparticles can be tuned to absorb near-infrared (NIR) light to exploit the maximum penetration of longer wavelengths into tissue within the biological absorption minimum window 15 .…”

Section: Introductionmentioning

confidence: 99%

Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids

McCarthy

Cudykier

Singh

et al. 2021

Sci Rep

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Colorectal cancer (CRC) treatment is currently hindered by micrometastatic relapse that cannot be removed completely during surgery and is often chemotherapy resistant. Targeted theranostic nanoparticles (NPs) that can produce heat for ablation and enable tumor visualization via their fluorescence offer advantages for detection and treatment of disseminated small nodules. A major hurdle in clinical translation of nanoparticles is their interaction with the 3D tumor microenvironment. To address this problem tumor organoid technology was used to evaluate the ablative potential of CD44-targeted polymer nanoparticles using hyaluronic acid (HA) as the targeting agent and coating it onto hybrid donor acceptor polymer particles (HDAPPs) to form HA-HDAPPs. Additionally, nanoparticles composed from only the photothermal polymer, poly[4,4-bis(2-ethylhexyl)-cyclopenta[2,1-b;3,4-b’]dithiophene-2,6-diyl-alt-2,1,3-benzoselenadiazole-4,7-diyl] (PCPDTBSe), were also coated with HA, to form HA-BSe NPs, and evaluated in 3D. Monitoring of nanoparticle transport in 3D organoids revealed uniform diffusion of non-targeted HDAPPs in comparison to attenuated diffusion of HA-HDAPPs due to nanoparticle-matrix interactions. Computational diffusion profiles suggested that HA-HDAPPs transport may not be accounted for by diffusion alone, which is indicative of nanoparticle/cell matrix interactions. Photothermal activation revealed that only HA-BSe NPs were able to significantly reduce tumor cell viability in the organoids. Despite limited transport of the CD44-targeted theranostic nanoparticles, their targeted retention provides increased heat for enhanced photothermal ablation in 3D, which is beneficial for assessing nanoparticle therapies prior to in vivo testing.

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“…More localized and effective hyperthermia can be achieved with heat-generating-nanoparticles compared to direct heating of the bulk carrier fluid by heat exchanger [18][19][20]. A recent study has shown that rapid hyperthermia generated by photothermal nanoparticles (nanoparticles capable of generating heat following light stimulation) can achieve increased cell killing in thermotolerant breast cancer stem cells compared to bulk heating [21].…”

Section: Introductionmentioning

confidence: 99%

Oxaliplatin-resistant colorectal cancer models for nanoparticle hyperthermia

McCarthy

Singh

Levi‐Polyachenko

2021

International Journal of Hyperthermia

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Introduction: Metastatic colorectal cancer (CRC) is complicated by chemotherapy-resistant cell populations. Oxaliplatin is used in heated intraperitoneal hyperthermic chemoperfusion (HIPEC) for treatment of disseminated CRC. Photothermal nanoparticles can provide focal heating to improve the response of CRC cells to oxaliplatin, by confining heating near individual cells. Reduction in cellular luciferase signal may allow single-cell-resolution recording of thermal dosimetry. Methods: Oxaliplatin resistant (OxR) variants of luciferase-expressing CT26.WT-Fluc-Neo CRC cells were developed and their sensitivity to hyperthermia was evaluated. Polymer-based photothermal nanoparticles were developed, characterized and used to explore their potential for imparting a thermal dose to improve cell response to oxaliplatin. A correlation of thermal dose to intracellular luciferase activity was established using quantitative luminescence monitoring and microscopy. Results: Luciferase-based monitoring of thermal dose within CT26 cell lines was validated within the ranges of 0.04-8.33 CEM43 for parental cells and 0.05-9.74 CEM43 for OxR CT26 cells. This was further confirmed using nanoparticle-induced hyperthermia, where the single-cell resolution of the thermal dose can be achieved. The nanoparticles enhance cell killing of resistant cells when combined with oxaliplatin and stimulated to generate heat. Conclusion: Nanoparticle-based hyperthermia is effective for augmenting chemotherapy and can be coupled with reductions in CT26 luciferase expression to monitor thermal dose at single-cell resolution. The development of OxR CT26.WT-Fluc-Neo CRC cells sets the stage for pre-clinical evaluations to measure nanoparticle-induced hyperthermia to augment chemotherapy (Nano-HIPEC) in a chemotherapy-resistant model of disseminated CRC.

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Review of Metal, Carbon and Polymer Nanoparticles for Infrared Photothermal Therapy

Cited by 30 publications

References 230 publications

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids

Oxaliplatin-resistant colorectal cancer models for nanoparticle hyperthermia

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