2012
DOI: 10.2147/ijnrd.s19165
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Review of eprodisate for the treatment of renal disease in AA amyloidosis

Abstract: Secondary (AA) amyloidosis is a multisystem disorder complicating chronic infections or inflammatory diseases. It is characterized by extracellular deposit of fibrils composed of fragments of serum amyloid A (SAA), an acute phase reactant protein. The kidney is the most frequent organ involved, manifesting as progressive proteinuria and renal impairment. Attenuation of the level of circulating SAA protein by treating the underlying inflammatory condition remains the primary strategy in treating AA amyloidosis.… Show more

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Cited by 10 publications
(3 citation statements)
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“…To this end, high dose chemotherapy is used to non-specifically eliminate monoclonal plasma cells in patients with AL, and anti-inflammatory agents are employed to halt the production of the acute phase sAA protein. Other approaches include the use of small molecules to block protein-protein interactions [35], [36], orthotopic liver transplantation for patients with hereditary ATTR [37], and more recently, small interfering RNA techniques have been used to specifically target and reduce the production of amyloid precursor proteins [38][40].…”
Section: Discussionmentioning
confidence: 99%
“…To this end, high dose chemotherapy is used to non-specifically eliminate monoclonal plasma cells in patients with AL, and anti-inflammatory agents are employed to halt the production of the acute phase sAA protein. Other approaches include the use of small molecules to block protein-protein interactions [35], [36], orthotopic liver transplantation for patients with hereditary ATTR [37], and more recently, small interfering RNA techniques have been used to specifically target and reduce the production of amyloid precursor proteins [38][40].…”
Section: Discussionmentioning
confidence: 99%
“…3335 In addition, sulfonated molecules such as 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid have been shown to be effective inhibitors of A β and serum amyloid A aggregation, respectively. 36,37 …”
Section: Resultsmentioning
confidence: 99%
“…GAG mimetics such as 3-amino-1-propanesulfonic acid ( 3 ) 63 and eprodisate disodium ( 4 ) 64 have been tested as anti-amyloid agents for the treatment of Alzheimer’s disease and amyloidosis. Polysulfonated compounds such as suramin ( 5 ), 65 poly(sodium-4-styrene sulfonate) ( 6 ), 66 and sulfonate polymers have been tested as well.…”
Section: Targeting Heparan Sulfate-protein Interactionsmentioning
confidence: 99%