Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms

Maqbool, Faheem; Mostafalou, Sara; Bahadar, Haji; Abdollahi, Mohammad

doi:10.1016/j.lfs.2015.10.022

Cited by 259 publications

(118 citation statements)

References 119 publications

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“…The endocrine disrupting effects in relation to different systems, organs and sources of exposure have been examined in a recent review, including both experimental and epidemiological data [11]. A key role for EDCs has been proposed in the pathogenesis of early puberty, infertility, altered quality of sperm, and reproductive disorders later in life in both animal and human studies [11]. Altered thyroid and adrenal hormones biosynthesis and functions have been also included among commonly occurring EDCs adverse effects [11].…”

Section: Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

“…A key role for EDCs has been proposed in the pathogenesis of early puberty, infertility, altered quality of sperm, and reproductive disorders later in life in both animal and human studies [11]. Altered thyroid and adrenal hormones biosynthesis and functions have been also included among commonly occurring EDCs adverse effects [11]. In addition, a growing body of evidence indicates a pivotal role for EDCs in promoting the obesity epidemics [12].…”

Section: Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

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Endocrine Aspects of Environmental “Obesogen” Pollutants

Nappi

Barrea

Somma

et al. 2016

IJERPH

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Growing evidence suggests the causal link between the endocrine-disrupting chemicals (EDCs) and the global obesity epidemics, in the context in the so-called “obesogenic environment”. Dietary intake of contaminated foods and water, especially in association with unhealthy eating pattern, and inhalation of airborne pollutants represent the major sources of human exposure to EDCs. This is of particular concern in view of the potential impact of obesity on chronic non-transmissible diseases, such as type 2 diabetes, cardiovascular disease, and hormone-sensitive cancers. The key concept is the identification of adipose tissue not only as a preferential site of storage of EDCs, but also as an endocrine organ and, as such, susceptible to endocrine disruption. The timing of exposure to EDCs is critical to the outcome of that exposure, with early lifetime exposures (e.g., fetal or early postnatal) particularly detrimental because of their permanent effects on obesity later in life. Despite that the mechanisms operating in EDCs effects might vary enormously, this minireview is aimed to provide a general overview on the possible association between the pandemics of obesity and EDCs, briefly describing the endocrine mechanisms linking EDCs exposure and latent onset of obesity.

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Section: Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

Section: Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

Endocrine Aspects of Environmental “Obesogen” Pollutants

Nappi

Barrea

Somma

et al. 2016

IJERPH

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“…For example, Mouly et al found an inconclusive relationship between PCB and breast cancer 53 ; two other reviews showed a positive association between PCB and breast cancer. 54,56 Similarly, our content analysis showed that of the webpages discussing research studies, 56.3% (n=9) showed non-significant or inconclusive relationship, while 43.8% (n=7) showed increased risk due to PCB exposure. While webpages mainly discussed the negative aspects of PCB exposure and breast cancer risk, the uncertainty about the exact nature of the relationship was evident.…”

Section: Discussionmentioning

confidence: 68%

A Comprehensive Analysis of How Environmental Risks of Breast Cancer Are Portrayed on the Internet

Kulkarni

Lewis

Adams

et al. 2018

American Journal of Health Education

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Background Effective online communication about the environmental risk factors of breast cancer is essential because of the multitude of environmental exposures and debate regarding the conclusiveness of scientific evidence. Purpose The aim of this study was to assess the content, readability, and cultural sensitivity of online resources focused on the environmental risks factors of breast cancer. Methods A purposive sample of webpages focused on environmental risk factors of breast cancer was obtained through a Google search using 17 search terms. Using nonparametric statistics, we assessed the content, readability, and cultural appropriateness of 235 webpages. Results Eighty-two percent of webpages referred to research studies in their content. For the majority of sites, readability was at a high-school reading grade level. Webpages were not explicitly intended for specific racial/ethnic groups. Discussion Technical language and non-culturally specific messages may hinder users’ attention to and comprehension of online breast cancer information. Additional research is needed to examine in-depth the accuracy of this online content. Translation to Health Education Practice Findings suggest that collaborations between scientists, health educators, website designers/media professionals, and the community will be critical to the delivery of accurate, up-to-date, plain-language, and culturally sensitive information about breast cancer and the environment.

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“…The treated male was being observed for their ability in mating the normal female rats where the results showed low mating and fertility indices (El-Mazoudy et al, 2011). According to the researchers, Chlorpyrifos knew as the estrogenic agent that acts by catalysing androgen and estrogen production through P450 aromatase stimulation hence disrupting the regulation of steroid hormone biosynthesis by testis (Maqbool et al, 2015). Besides, Chlorpyrifos-ethyl which was given orally at various doses such as 3.5, 5.25 and 10.5 mg/kg have been reported to give the same effects towards male rats which also due to the alterations in the male jas.ccsenet.org Journal of Agricultural Science Vol.…”

Section: Endocrine Disruptionmentioning

confidence: 99%

Pesticide Exposures Induce Male-Mediated Reproductive Toxicity: A Review

Yusoff¹,

Budin²,

Taib³

2017

JAS

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Infertility remains a continuing globally problem wherever couples worldwide were infertile as much as 42 million in 1990 and keep projecting to 48.5 million in 2010. Male-mediated infertility becomes one of the numerous concerns due to pesticide especially sperm quality as revealed with raising number of animal and human studies in latter-day among researchers. Pesticides have been used since the early days as pest control in agriculture, as vector controls in malaria and dengue as well as subject to much regulation. The reproductive system might be affected with some negative effects from pesticides that lead to interference with the male hormonal function. Polyunsaturated fatty acid (PUFA) content in the sperm cell membrane makes it become highly susceptible towards reactive oxygen species (ROS), thus leading to sperm damage. Besides known genetic and environmental factors, research during the last two decades has highlight on several mechanisms and their association with male infertility. The male germ line undergoes extensive epigenetic modifications throughout fetal to adult life hence vulnerable to environmental factors that may influence fertility. The present literature will help in understanding the mechanisms of pesticide in inducing male-mediated reproductive toxicity.

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Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms

Cited by 259 publications

References 119 publications

Endocrine Aspects of Environmental “Obesogen” Pollutants

Endocrine Aspects of Environmental “Obesogen” Pollutants

A Comprehensive Analysis of How Environmental Risks of Breast Cancer Are Portrayed on the Internet

Pesticide Exposures Induce Male-Mediated Reproductive Toxicity: A Review

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