Review of current clinical studies of vitiligo treatments

Коробко, И. В.

doi:10.1111/dth.12008

Cited by 18 publications

(10 citation statements)

References 101 publications

(246 reference statements)

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“…Along with that, several experimental topical agents were reported, among which are prostaglandins (prostaglandin E2 and prostaglandin F2α analogue latanoprost) investigated in several small‐size pilot studies . Similarly to many other examples , combination of latanoprost with narrow‐band ultraviolet B (NB‐UVB) phototherapy showed superior effect over either of the monotherapy , thus pointing on beneficial effect of combination NB‐UVB with topical prostaglandins. Notably, while several pilot evaluations suggest beneficial effects of topical prostaglandins on repigmentation in vitiligo, their efficiency compared with conventional topical drugs used in vitiligo treatment has not been addressed before.…”

Section: Introductionmentioning

confidence: 98%

“…Along with that, several experimental topical agents were reported, among which are prostaglandins (prostaglandin E2 and prostaglandin F2a analogue latanoprost) investigated in several small-size pilot studies (1)(2)(3). Similarly to many other examples (4,5), combination of latanoprost with narrow-band ultraviolet B (NB-UVB) phototherapy showed superior effect over either of the monotherapy (3), thus pointing on Ctrl.…”

Section: Introductionmentioning

confidence: 99%

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A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo

Коробко¹,

Lomonosov

2016

Dermatologic Therapy

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Prostaglandins and their analogues are beneficial as topical agents in vitiligo treatment, yet neither of the previous study addressed their comparative efficiency with conventional topical agents used in vitiligo treatment. In this pilot (24 patients) left-right comparative study we addressed efficiency of prostaglandin F2α analogue latanoprost versus tacrolimus when combined with narrow-band ultraviolet B and microneedling in repigmentation of nonsegmental vitiligo lesions. Our results confirm potency of prostaglandins, in particular, that of latanoprost, in inducing repigmentation, with the efficiency being at least comparable to that of tacrolimus, while contribution of microneedling remains unclear. In summary, results of our study provide further evidences for justified use of prostaglandins, in particular, latanoprost, in vitiligo treatment. In turn, this warrants future studies on the topic aiming to conclusively introduce prostaglandin-based formulations as conventional agents for vitiligo management.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo

Коробко¹,

Lomonosov

2016

Dermatologic Therapy

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“…The results of different treatments are controversial and often undesirable. Several therapies for vitiligo include: topical and systemic corticosteroids, calcineurin inhibitors, PUVA (psoralen and UV A radiation), NBUVB (narrow band UV B radiation), various surgical and laser methods, vitamin D analogues, antioxidants, herbal products, etc (Korobko, 2012;Rodrigues et al, 2017). There is not yet a single therapeutic approach with high efficacy and low side effects to cure vitiligo (Speeckaert, Speeckaert, & van Geel, 2015).…”

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confidence: 99%

Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double‐blind clinical trial study

Dailami

Hosseini

Rokni

et al. 2019

Dermatologic Therapy

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Numerous studies have demonstrated that the pigmentation of iris and around the eyelid is a common side effect of latanoprost, a prostaglandin F2alpha analogue used in the treatment of glaucoma. Hence, the authors decided to study the effectiveness of topical latanoprost on vitiligo patches around the eyelid. In this randomized, double-blind, clinical trial study, 31 patients with vitiligo vulgaris and focal vitiligo involving the eyelids were evaluated. Patients were randomly divided into two groups. First group received topical latanoprost gel twice daily for 12 weeks, whereas the second group received placebo with the same protocol. To evaluate severity of the disease the VIDA rating system was used. Serial photos of the patches were taken to compare and evaluate the repigmentation percentage of the patches. The patients in both groups had almost similar VIDA score (p > .05). First group showed improved pigmentation, whereas participants in the second group did not show any improvement in the pigmentation. The group treated with latanoprost showed significant reduction in the symptoms of the disease, whereas those treated with placebo did not show any alteration (p > .05). No significant complications were observed in either groups. Latanoprost proved effective in treating vitiligo disease involving eyelids.

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“…Several factors seem to predict Na‐AAA treatment efficacy. Among them, shorter disease duration and younger age were also noted as favorable prognostic factors for several other vitiligo treatment modalities , thus further warranting early after onset vitiligo treatment. Although significance and accuracy of the identified predicting factors are to be verified in larger studies, they potentially provide a basis for individual choice of the most efficient treatment modality.…”

Section: Discussionmentioning

confidence: 99%

Acridone acetic acid, sodium salt, as an agent to stop vitiligo progression: a pilot study

Коробко¹,

Lomonosov

2014

Dermatol Ther

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Vitiligo progression is attributed to immune system malfunctioning, thus immunomodulating compounds might be beneficial in stopping vitiligo progression which is a prerequisite for successful repigmentation. The goal of this study was to assess efficacy of acridone acetic acid, sodium salt (Na-AAA), an immunomodulating compound with favorable safety profile, in stabilizing active vitiligo, and to reveal prognostic factors of treatment outcome. Sixty consecutive patients with progressing nonsegmental vitiligo were treated with 10 i.m. injections of Na-AAA every other day. Disease stability was assessed in 1, 3, 6, and 12 months post-treatment. Statistical analysis was applied to correlate treatment outcome and available clinical parameters. Of the 60 patients treated, vitiligo stopped progression in 44 patients (73.3%). Older age (p = 0.0219), age of 35 and older (p = 0.0189, odds ratio (OR) = 5.2, 95% confidence interval (CI) 1.30-20.84) or age of 40 and older (p = 0.0039, OR = 6.48, 95% CI 1.86-22.61), longer disease duration (p = 0.0234), pre-treatment interleukin-6 level over 2 pg/mL (p = 0.0005, OR = 13.7, 95% CI 2.97-63), and over the reference threshold value 5.9 pg/mL (p = 0.0009, OR = 25.8, 95% CI 2.8-239) as well as presence of other autoimmune diseases (p = 0.038, OR = 7.0, 95% CI 1.14-42.97) were negative prognostic factors of treatment success. In conclusion, acridone acetic acid, sodium salt, emerges as an efficient option for stopping vitiligo progression.

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Review of current clinical studies of vitiligo treatments

Cited by 18 publications

References 101 publications

A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo

A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo

Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double‐blind clinical trial study

Acridone acetic acid, sodium salt, as an agent to stop vitiligo progression: a pilot study

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