Review of Consecutive Ten Year Intervals

Adashek, Kenneth; Sanger, James R.; Longmire, William P.

doi:10.1097/00000658-197901000-00002

Cited by 104 publications

(27 citation statements)

References 4 publications

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“…These figures are not likely to change until fibreoptic endoscopy becomes a screening procedure rather than a diagnostic one, as the Japanese experience has shown [7]. The overall operative mortality of 12.3% was related more to the stage of disease rather than the extent of operation in this series, as in others [3,[8][9][10]. Prognosis depends upon the overall stage of disease at presentation especially the status of regional lymph nodes.…”

Section: Discussionmentioning

confidence: 56%

“…Most published series report poor survival figures in stomach cancer, with the five year survival varying between 7-10% [3,5,8] with upto 54% of all cases having surgically incurable lesions at laparotomy [9]. Review of our data indicates that the proportion of early, curable gastric cancers being operated has not increased despite increased use of fibreoptic endoscopy.…”

Section: Discussionmentioning

confidence: 82%

“…are associated with higher operative mortality and do not prolong survival [3,8,10]. In this series, the number of extended resection carried out is too small to permit us to draw any meaningful conclusions in this regard.…”

Section: Discussionmentioning

confidence: 99%

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Adenocarcinoma Stomach a Review of 168 Cases

Vohra

Subhas

Rajagopal³

et al. 1994

Medical Journal Armed Forces India

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ABSTRACfMedical records of 168 patients with gastric adenocarcinoma treated at Malignant Diseases Treatment Centre. Command Hospital (SC)Pune over a ten year period were analysed. Laparotomy was performed in 146 patients; in 82 patients a gastric resection was done. palliative gastrojejunostomy was done in 42 patients. while in 22 patients only a diagnostic biopsy was done. The resection was considered to be curative in 21 patients. Overall operative mortality was 12.3%. According to the international TNM Classification 16% patients were in Stage 1,13.7% in Stage 11.34.3% in Stage III and 35.8% in Stage IV. A significant correlation was found between five year survival rate and overall stage of disease as well as regional lymph node involvement (p < 0.001). Significantly better survival rates were seen in those who had curative resection as opposed to palliative resection (p < 0.01). Overall survival rate at five years-in our patients was 8.3% this poor outcome was probably related to the advanced stage of disease at presentation. M]AF11994. 50: 89-91

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 82%

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Adenocarcinoma Stomach a Review of 168 Cases

Vohra

Subhas

Rajagopal³

et al. 1994

Medical Journal Armed Forces India

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“…Similarly, in gastric cancer, DC infiltration into the primary tumor was reported to decrease the progression of nodal involvement and lead to good survival rates (20)(21)(22)(23)(24)(25). Lymph node metastasis is a crucial factor that influences prognosis, and patients with nodal involvement in gastric cancer have a poor clinical course compared with those without metastasis (26). However, the clinical significance of micrometastases (MM) still remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of immune response according to the metastatic status in the regional lymph nodes in patients with gastric carcinoma

Nakamura

Ninomiya²,

Oyama³

et al. 2010

Oncol Rep

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Abstract. The immunological response in the regional lymph nodes (LN) of gastric cancer patients who had metastasis was studied by investigating both the degree of metastasis and the maturation status of dendritic cells (DCs). A total of 732 LNs was obtained from 29 gastric cancer patients, including 25 patients whose LNs were pathological metastasis-negative and 4 patients with metastasis-positive LNs. Micrometastasis (MM) in the LNs was analyzed by immunohistochemical staining of cytokeratin (CK) (IHC-MM) and by amplifying CEA and CK19 mRNA by quantitative real-time RT-PCR (PCR-MM). Distribution and density of mature DCs were evaluated in 119 LNs from pathological metastasis-positive cases by examining CD83 expression immunohistochemically. Then, following the examination of PCR-MM, immunological responses were analyzed by amplifying CD83, CD86, CD1a and IFNÁ mRNA by quantitative real-time RT-PCR in 613 LNs from 25 pathological metastasis-negative cases. Among 119 LNs from 4 patients with LN metastasis, 20 LNs had histological metastasis and 6 histological metastasis-negative LNs had IHC-MM. The distribution and density of mature DCs were identical in the LNs regardless of metastasis status. Among 613 LNs from 25 patients without histological LN metastasis, 15 LNs (2.45%) from 6 cases (24%) were PCR-MM positive. The expression levels of CD83 and CD86 mRNA were significantly higher in the 15 PCR-MM-positive LNs than in the 598 PCR-MMnegative LNs. The expression levels of CD83 and CD86 mRNA in 136 PCR-MM-negative LNs from 6 PCR-MMpositive cases were also higher than those in 462 LNs from 19 PCR-MM-negative cases. In gastric cancer patients, activation of the immune response by maturation of DCs is wide-spread in regional lymph nodes at a stage before metastasis is detected histologically, including detection by IHC-MM.

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“…Lymph node and peritoneal métastasés of gastric cancer arc the major factors [1,2] influencing prognosis after surgery in patients with gastric cancer. Our previous studies [3][4][5][6][7][8] reveal ed that activated carbon particles adsorb a large amount of mitomycin(MMC) on their surface and subsequently release the drug.…”

Section: Introductionmentioning

confidence: 99%

Intensive Intraoperative Local Chemotherapy for Lymph Node and Peritoneal Metastases in Gastric Cancer

Takahashi¹,

Hagiwara²,

Sawai³

et al. 1991

Oncol Res Treat

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Two types of local chemotherapies were combined intraoperatively with gastric resection for gastric cancer. One chemotherapy was intralymph nodal injection of mitomycin C adsorbed on small activated carbon particles suspension for lymph nodal metastases. This therapy improved the survival rates statistically significantly as compared with those of the historical control group. The other chemotherapy was intraperitoneal administration of mitomycin C adsorbed on relatively large particles of activated carbon for the prophylaxis and the treatment of peritoneal metastases in gastric cancer with macroscopically remarkable serosal infiltration. This therapy also improved the survival rates statistically significantly as compared with those of the control groups in a randomized study.

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Review of Consecutive Ten Year Intervals

Cited by 104 publications

References 4 publications

Adenocarcinoma Stomach a Review of 168 Cases

Adenocarcinoma Stomach a Review of 168 Cases

Evaluation of immune response according to the metastatic status in the regional lymph nodes in patients with gastric carcinoma

Intensive Intraoperative Local Chemotherapy for Lymph Node and Peritoneal Metastases in Gastric Cancer

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