Review of companion animal viral diseases and immunoprophylaxis

Patel, Jay; Heldens, J.G.M.

doi:10.1016/j.vaccine.2008.11.027

Cited by 25 publications

(24 citation statements)

References 130 publications

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“…44 In contrast, parvoviral infections in dogs are associated with a high mortality rate ( > 90%) and the disease is extremely contagious and can be devastating in a colony setting. 45 Because of the dangerous nature of the canine parvoviral infection, most puppies are immunized between 4 and 6 weeks of age to prevent disease. Both canine parvovirus and AAV are members of the Parvoviridae family and share sequence identity.…”

Section: Discussionmentioning

confidence: 99%

Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs

Nichols

Whitford

Arruda

et al. 2015

Human Gene Therapy Clinical Development

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Preclinical testing of new therapeutic strategies in relevant animal models is an essential part of drug development. The choice of animal models of disease that are used in these studies is driven by the strength of the translational data for informing about safety, efficacy, and success or failure of human clinical trials. Hemophilia B is a monogenic, X-linked, inherited bleeding disorder that results from absent or dysfunctional coagulation factor IX (FIX). Regarding preclinical studies of adeno-associated virus (AAV)-mediated gene therapy for hemophilia B, dogs with severe hemophilia B (<1% FIX) provide well-characterized phenotypes and genotypes in which a species-specific transgene can be expressed in a mixed genetic background. Correction of the hemophilic coagulopathy by sustained expression of FIX, reduction of bleeding events, and a comprehensive assessment of the humoral and cell-mediated immune responses to the expressed transgene and recombinant AAV vector are all feasible end points in these dogs. This review compares the preclinical studies of AAV vectors used to treat dogs with hemophilia B with the results obtained in subsequent human clinical trials using muscle- and liver-based approaches.

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Section: Discussionmentioning

confidence: 99%

Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs

Nichols

Whitford

Arruda

et al. 2015

Human Gene Therapy Clinical Development

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“…Many inactivated vaccines also contain adjuvants or immunopotentiators [168–170]. Veterinary vaccines are subjected to rigorous safety testing and evaluation prior to authorisation [171, 172] but vaccination is not without risks in humans, and in animals although these risks are low [29, 173–178]. …”

Section: The Possible Role Of Chronic Inflammationmentioning

confidence: 99%

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

Woodward¹

2011

ISRN Veterinary Science

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The etiology of feline injection-site sarcomas remains obscure. Sarcomas and other tumors are known to be associated with viral infections in humans and other animals, including cats. However, the available evidence suggests that this is not the case with feline injection-site sarcomas. These tumors have more in common with sarcomas noted in experimental studies with laboratory animals where foreign materials such as glass, plastics, and metal are the causal agent. Tumors arising with these agents are associated with chronic inflammation at the injection or implantation sites. Similar tumors have been observed, albeit infrequently, at microchip implantation sites, and these also are associated with chronic inflammation. It is suggested that injection-site sarcomas in cats may arise at the administration site as a result of chronic inflammation, possibly provoked by adjuvant materials, with subsequent DNA damage, cellular transformation, and clonal expansion. However, more fundamental research is required to elucidate the mechanisms involved.

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“…Canine distemper virus (CDV), a Morbillivirus of the family Paramyxoviridae causes a highly systemic infection with prominent respiratory, gastrointestinal, and nervous signs in dogs (Patel and Heldensb 2009). The disease is characterized by a rapid onset of severe leucopenia and loss of lymphocyte proliferation ability.…”

Section: Introductionmentioning

confidence: 99%

Isolation and molecular characterization of canine distemper virus from India

Pawar

Raj

Gopinath

et al. 2011

Trop Anim Health Prod

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Ocular swabs from canine distemper virus (CDV) suspected live or brain tissue from dead dogs were tested for the presence of CDV nucleoprotein (N) gene using reverse transcriptase polymerase chain reaction (RT-PCR). Partial "N" gene sequencing of the RT-PCR-positive samples and the local vaccine virus revealed that the Ind/Andaman 01/07 virus was highly divergent from the rest of the CDV isolates and from the vaccine strain. Quantitative real-time PCR (qRT-PCR) using SYBR Green I chemistry for CDV haemagglutinin "H" gene quantification showed C(t) values ranging from 29.76-30.67 in the RT-PCR-positive samples. Two of the positive samples, designated Ind/TN 01/07 and Ind/Andaman 01/07 were used for virus isolation in B95a cell line. Characteristic cytopathic changes such as rounding of cells, syncytia formation, and ballooning were seen from the first passage onwards. Specific cytoplasmic fluorescence was seen in infected cells with a commercial reference serum against CDV. To the best of our knowledge, this is the first report of CDV isolation from clinical cases in India.

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Review of companion animal viral diseases and immunoprophylaxis

Cited by 25 publications

References 130 publications

Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs

Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs

Origins of Injection-Site Sarcomas in Cats: The Possible Role of Chronic Inflammation—A Review

Isolation and molecular characterization of canine distemper virus from India

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