Review of Comorbidities of Hidradenitis Suppurativa: Implications for Daily Clinical Practice

Abstract

Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severity and effect of treatment, along with the use of clinically important patient reported outcomes, is essential. The potential of available treatments to negatively and positively affect these comorbidities should also be taken into account when designing treatment strategies. This review provides an outline of important HS comorbidities with emphasis on possible implications for daily clinical practice.

Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature

“…Children and adults with HS suffer from the same complications, such as anaemia, lymphoedema and sinus tract formation to the surrounding organs (bladder, rectum). 4,30 Serious cutaneous, extracutaneous and systemic infections, associated with higher mortality, may also complicate the course of HS patients. 31 HS is also associated with various comorbid disorders, with no reported differences between early and adult onset.…”

Quality of Life in Cohabitants of Patients with Hidradenitis Suppurativa: A Cross-sectional Study

“…It is characterized by nodules, abscesses, fistulae and large scarred areas and usually accompanied by pain and purulent secretions with unpleasant odor [ 1 , 2 ]. Obesity, tobacco and hormonal disorders have been postulated as the main factors that influence the onset and evolution of the disease [ 2 ], and it has been associated with multiple physical comorbidities such as spondyloarthritis, inflammatory bowel disease and increased cardiovascular risk [ 3 , 4 ]. Since HS is an autoinflammatory skin disorder [ 5 , 6 ] with a great clinical heterogeneity, a growing body of comorbidities both cutaneous [ 7 ] and extracutaneous [ 3 , 4 , 8 ] were claimed to be linked to it.…”

Hidradenitis suppurativa: Infektion, Autoimmunkrankheit oder beides?

“…Ein Drittel der HS Patienten gibt eine positive Familienanamnese an und die Erkrankung weist einen autosomaldominanten Erbgang auf. Zu den häufigsten Komorbiditäten der HS gehören unter anderem Morbus Crohn, Colitis ulcerosa, Spondylarthropathie und metabolisches Syndrom [2]. Genetische Prädisposition, endokrinologische Störungen, dysregulierte erworbene Immunität, bakterielle Superinfektion, Rauchen und Adipositas gehören zu den begünstigenden Faktoren [1].…”