Review of Colorectal Studies Using the National Cancer Database

Kelley, Katherine A.; Tsikitis, Vassiliki L.

doi:10.1055/s-0038-1673356

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…Studies have evaluated the research utility of the US NCDB (National Cancer Database) and SEER (Surveillance, Epidemiology and End Results) database, which emphasizes the importance of promoting awareness of the data available to facilitate research. 34,35 In terms of future development of these data sources, patient reported outcome measures and functional bowel outcomes that would impact on quality of life after cancer surgery are increasingly recognized outcome measures influencing treatment decision making in cancer care. 36,37 Benign surgical outcomes such as incisional hernia rate and small bowel obstruction could similarly have an impact on patient quality of life.…”

Section: Discussionmentioning

confidence: 99%

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Colorectal cancer databases and registries in Australia: what data is available?

Tham

Skandarajah

Hayes

2021

ANZ Journal of Surgery

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Background There are multiple data sources relating to colorectal cancer (CRC) nationwide. Prospective clinical cancer databases, population‐based registries and linked administrative data are powerful tools in clinical outcomes research and provide real‐world perspective on cancer treatments. This study aims to review the different Australian data sources for CRC from the perspective of conducting comparative research studies using a PICO (patient, intervention, comparison, outcome) framework. Methods Data dictionaries from the different data sources were evaluated for the types of exposure and outcome variables contained to highlight their differing research utility. Results State or territory‐based cancer registries contain limited histology, cancer staging and treatment detail. They enable investigation of population‐level patterns in overall survival (OS) of cancer patients with different demographics. Prospective clinical cancer databases contain more detail, especially surgical. Their strength is in auditing short‐term surgical outcomes. They vary in the amount of data collected for other cancer treatments and completion of follow up data. Linked administrative databases have broad population coverage but less surgical detail. They provide population‐level data on treatment patterns, short‐term outcome measures and OS, as well as long‐term surgical outcomes such as identifying patients who did not undergo stoma reversal. These databases cannot assess disease‐free survival. Conclusion Of the various CRC data sources within Australia, linked administrative databases have the potential to provide the widest population coverage combined with the broadest range of exposures and outcomes, and arguably the most research utility.

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Section: Discussionmentioning

confidence: 99%

“…This has not been previously conducted in Australia. Studies have evaluated the research utility of the US NCDB (National Cancer Database) and SEER (Surveillance, Epidemiology and End Results) database, which emphasizes the importance of promoting awareness of the data available to facilitate research 34,35 …”

Section: Discussionmentioning

confidence: 99%

Colorectal cancer databases and registries in Australia: what data is available?

Tham

Skandarajah

Hayes

2021

ANZ Journal of Surgery

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“…A retrospective review of NSCLC was carried out using data from the National Cancer Database (NCDB), a public database maintained by Commission on Cancer (CoC)-accredited facilities. Sponsored by the American Cancer Society and the American College of Surgeons, this nationwide database encompasses patient and facility data from all 50 states and captures approximately 70% of all cancer cases [ 12 ]. The NCDB contains de-identified patient statistics, including information on demographics, socioeconomic factors, tumor characteristics, and outcomes [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Association Between Demographic and Socioeconomic Factors and Diagnosis of Advanced Non-small Cell Lung Cancer: An Analysis of the National Cancer Database

Verplancke,

Keirns,

McMahon

et al. 2023

Cureus

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Introduction Lung cancer is a prevalent and potentially lethal cancer. The stage at initial presentation for diagnosis predicts mortality and helps to guide treatment options. Thus, it is critical to determine what factors impact the stage of cancer at diagnosis. This study sought to determine if certain socioeconomic and demographic factors are associated with receiving an early (Stage 0-I) or advanced (Stage IV) diagnosis of non-small cell lung cancer (NSCLC). Methods Using the National Cancer Database (NCDB), 1,149,539 patients were identified as having an NCDB Analytic Stage Group diagnosis of Stage 0-I (early) versus Stage IV (advanced) NSCLC between 2004 and 2018. Patients with early and delayed diagnoses were compared based on specific characteristics including sex, race, ethnicity, number of comorbid conditions, insurance status, median annual income, level of education, geographic location, and reporting facility. Using IBM SPSS Statistics for Windows, Version 28 (Released 2021; IBM Corp., Armonk, New York, United States), the data underwent analysis using binary multivariate logistic regression, chi-square analyses, and one-way ANOVA. Results Factors associated with an advanced diagnosis of NSCLC include being male, Black, Native American, or Hispanic. Compared to patients with at least one comorbid condition, those without comorbid conditions are more likely to present with advanced disease. Patients with private insurance, Medicaid, Medicare, or other government insurance are all less likely to present with advanced-stage cancer than patients without insurance. Compared to patients in the lowest median household income quartile, those in the second and fourth quartiles are diagnosed earlier. Patients living in areas where a higher proportion of residents lack a high school diploma are more likely to present with advanced NSCLC. Additionally, living in the Midwest and Western United States and presenting to Community Cancer programs are associated with advanced disease at initial presentation. Conclusions Factors that were associated with the advanced presentation of NSCLC included being male, Black, Native American, or Hispanic, having a lack of comorbid conditions or insurance, earning a lower median annual income, and living in a zip code where a higher proportion of residents lack a high school diploma. Additionally, residing in the Midwest and Western United States and seeking care at Community Cancer programs were associated with advanced disease at initial presentation. Understanding that certain socioeconomic and demographic factors impact the stage at initial diagnosis of NSCLC can allow for targeted intervention strategies aimed at the most at-risk individuals, areas, and facilities.

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“…The NCDB is a very large database managed by the American College of Surgeons, comprising information from Commission on Cancer (CoC)-accredited facilities. The database has been used in several cancer-focused studies (Losk et al 2016 ; Kelley and Tsikitis 2019 ). Data were obtained from the NCDB Participant Use Data File (PUF).…”

Section: Methodsmentioning

confidence: 99%

Associated factors and outcomes of delaying adjuvant chemotherapy in breast cancer by biologic subtypes: a National Cancer Database study

Kumar

Paulraj

Wang

et al. 2021

J Cancer Res Clin Oncol

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Review of Colorectal Studies Using the National Cancer Database

Cited by 4 publications

References 31 publications

Colorectal cancer databases and registries in Australia: what data is available?

Colorectal cancer databases and registries in Australia: what data is available?

Association Between Demographic and Socioeconomic Factors and Diagnosis of Advanced Non-small Cell Lung Cancer: An Analysis of the National Cancer Database

Associated factors and outcomes of delaying adjuvant chemotherapy in breast cancer by biologic subtypes: a National Cancer Database study

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