Review of cinacalcet hydrochloride in the management of secondary hyperparathyroidism

Yousaf, Farhanah; Charytan, Chaim

doi:10.3109/0886022x.2013.832319

Cited by 10 publications

(8 citation statements)

References 110 publications

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“…The studies by Jun-Bean (2013) [29], Jan-P v K [34] (2010), Marcello (2009) [33], Michael [21] (2013), W.-S. [30] (2010) and Grandi [24] (2012) targeted at CVD patients. While CKD patients were the main subjects in Andrew [28] (2013) and Bryan K [41] (2005) studies. We chose patients with CKD stages 1–2 as study subjects in studies like these.…”

Section: Resultsmentioning

confidence: 99%

Can Serum Levels of Alkaline Phosphatase and Phosphate Predict Cardiovascular Diseases and Total Mortality in Individuals with Preserved Renal Function? A Systemic Review and Meta-Analysis

Cui

Fan

et al. 2014

PLoS ONE

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BackgroundIt is demonstrated that elevated serum levels of alkaline phosphatase (ALP) and phosphate indicate a higher risks of cardiovascular disease (CVD) and total mortality in population with chronic kidney disease (CKD), but it remains unclear whether this association exists in people with normal or preserved renal function.MethodClinical trials were searched from Embase and PubMed from inception to 2013 December using the keywords “ALP”, “phosphate”, “CVD”, “mortality” and so on, and finally 24 trials with a total of 147634 patients were included in this study. Dose-response and semi-parametric meta-analyses were performed.ResultsA linear association of serum levels of ALP and phosphate with risks of coronary heart disease (CHD) events, CVD events and deaths was identified. The relative risk(RR)of ALP for CVD deaths was 1.02 (95% confidence interval [CI], 1.01–1.04). The RR of phosphate for CVD deaths and events was 1.05 (95% CI, 1.02–1.09) and 1.04 (95% CI: 1.03–1.06), respectively. A non-linear association of ALP and phosphate with total mortality was identified. Compared with the reference category of ALP and phosphate, the pooled RR of ALP for total mortality was 1.57 (95% CI, 1.27–1.95) for the high ALP group, while the RR of phosphate for total mortality was 1.33 (95% CI, 1.21–1.46) for the high phosphate group. It was observed in subgroup analysis that higher levels of serum ALP and phosphate seemed to indicate a higher mortality rate in diabetic patients and those having previous CVD. The higher total mortality rate was more obvious in the men and Asians with high ALP.ConclusionA non-linear relationship exists between serum levels of ALP and phosphate and risk of total mortality. There appears to be a positive association of serum levels of ALP/phosphate with total mortality in people with normal or preserved renal function, while the relationship between ALP and CVD is still ambiguous.

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Section: Resultsmentioning

confidence: 99%

Can Serum Levels of Alkaline Phosphatase and Phosphate Predict Cardiovascular Diseases and Total Mortality in Individuals with Preserved Renal Function? A Systemic Review and Meta-Analysis

Cui

Fan

et al. 2014

PLoS ONE

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“…Like the mGluRs, of more therapeutic relevance are the allosteric modulators of CaSR. The calcimimetic drug cinacalcet ( 164 , Figure ) was the first allosteric GPCR modulator that reached the pharmaceutical market, which has been approved for the treatment of hyperparathyroidism in 2004 . This drug, however, causes the adverse side effect hypocalcaemia, likely through the activation of CaSR in tissues other than the parathyroid gland.…”

Section: Biased Ligands/allosteric Modulators At Class C Gpcrsmentioning

confidence: 99%

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure–Functional Selectivity Relationships (SFSRs) and Therapeutic Potential

et al. 2018

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G protein-coupled receptors (GPCRs) signal through both G-protein-dependent and G-protein-independent pathways, and β-arrestin recruitment is the most recognized one of the latter. Biased ligands selective for either pathway are expected to regulate biological functions of GPCRs in a more precise way, therefore providing new drug molecules with superior efficacy and/or reduced side effects. During the past decade, biased ligands have been discovered and developed for many GPCRs, such as the μ opioid receptor, the angiotensin II receptor type 1, the dopamine D receptor, and many others. In this Perspective, recent advances in this field are reviewed by discussing the structure-functional selectivity relationships (SFSRs) of GPCR biased ligands and the therapeutic potential of these molecules. Further understanding of the biological functions associated with each signaling pathway and structural basis for biased signaling will facilitate future drug design in this field.

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“…We used the methods by Nicola et al [11] to judge linearity. We used a restricted cubic spline model with three knots at percentiles 10, 50, and 90 % of the levels of phosphate, and then estimated pooled RR using generalized least square regression taking into account the correlation among categories of one study.…”

Section: Discussionmentioning

confidence: 99%

Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis

Cui

2014

Neurol Sci

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Elevated serum phosphate is associated with cardiovascular and total mortality in patients with kidney diseases and healthy individuals. But whether serum phosphate is associated with stroke is controversial. We searched PubMed and Embase from January 1, 1970 to May 9, 2014 with keywords such as "serum phosphate", "serum phosphorus", and "stroke". Dose-response meta-analysis was conducted. A restricted cubic spline model was used, and then we estimated pooled RR using generalized least square regression taking into account the correlation among categories of each study. Five studies with a total of 32,608 patients were included. We identified a linear relationship between serum phosphate and risk of stroke (P for non-linearity = 0.5258). The RR of phosphate (1 mg/dL) for stroke was 1.00 (95 % CI 0.97-1.05), similar results were observed in subgroup analysis. A linear relationship between serum phosphate and risk of stroke is identified. There is no association between serum level of phosphate and stroke.

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Review of cinacalcet hydrochloride in the management of secondary hyperparathyroidism

Cited by 10 publications

References 110 publications

Can Serum Levels of Alkaline Phosphatase and Phosphate Predict Cardiovascular Diseases and Total Mortality in Individuals with Preserved Renal Function? A Systemic Review and Meta-Analysis

Can Serum Levels of Alkaline Phosphatase and Phosphate Predict Cardiovascular Diseases and Total Mortality in Individuals with Preserved Renal Function? A Systemic Review and Meta-Analysis

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure–Functional Selectivity Relationships (SFSRs) and Therapeutic Potential

Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis

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