Review of Chemical Sensors for Hydrogen Sulfide Detection in Organisms and Living Cells

Abstract

As the third gasotransmitter, hydrogen sulfide (H2S) is involved in a variety of physiological and pathological processes wherein abnormal levels of H2S indicate various diseases. Therefore, an efficient and reliable monitoring of H2S concentration in organisms and living cells is of great significance. Of diverse detection technologies, electrochemical sensors possess the unique advantages of miniaturization, fast detection, and high sensitivity, while the fluorescent and colorimetric ones exhibit exclusive visualization. All these chemical sensors are expected to be leveraged for H2S detection in organisms and living cells, thus offering promising options for wearable devices. In this paper, the chemical sensors used to detect H2S in the last 10 years are reviewed based on the different properties (metal affinity, reducibility, and nucleophilicity) of H2S, simultaneously summarizing the detection materials, methods, linear range, detection limits, selectivity, etc. Meanwhile, the existing problems of such sensors and possible solutions are put forward. This review indicates that these types of chemical sensors competently serve as specific, accurate, highly selective, and sensitive sensor platforms for H2S detection in organisms and living cells.

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer’s Disease: A Recent Systematic Review

“…Elevated H 2 S levels have been linked to various diseases, including Alzheimer's and type 1 diabetes, underscoring the necessity for efficient diagnostic tools. The ECL system employs a novel redox-stable chemosensor, an iridium (III) complex (Probe) that features a "turn-on" mechanism triggered by the specific cleavage of 2,4-dinitrophenyl ether (DNP) in the presence of H 2 S. This approach fills a gap in current detection methodologies, which often suffer from high operational complexity, cost, and time consumption [159].…”

Influence of Be vacancy on 2D BeN4 single-layer for enhanced H2S sensing: prediction from first-principles simulations

“…Gas chromatography and/or spectrometry are commonly used analytical methods to quantify H 2 S concentration in air. Among the gas sensing devices developed for industrial purposes, chemiresistive, electrochemical, and optical sensors are the most popular for H 2 S detection [6,7]. The principle of electrochemical H 2 S sensors is that H 2 S disperses over a previous sheath, and as the fraction of H 2 S upsurges in air, an oxidation or reduction response happens at either electrode.…”