Review of Cardiovascular Disease in HIV-Infected Women

Adekunle, Ruth

doi:10.4172/2155-6113.1000557

Cited by 2 publications

(5 citation statements)

References 50 publications

(70 reference statements)

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“…Our study included only patients in the United States, which may limit the generalizability of our findings to patient populations in other countries. However, some of our findings have been reported in other countries . Due to the nature of the database, long‐term follow‐up of these patients is not available.…”

Section: Discussionmentioning

confidence: 77%

“…Females with HIV have been associated with young age and a higher prevalence of both HTN and DM as compared with men with HIV . Young black females in particular appear to be at an increased risk of ACS in the setting of HIV infection .…”

Section: Discussionmentioning

confidence: 99%

“…9 Females with HIV have been associated with young age and a higher prevalence of both HTN and DM as compared with men with HIV. [27][28][29] Young black females in particular appear to be at an increased risk of ACS in the setting of HIV infection. 29,30 The reasons behind this observation may be multifactorial, inclusive of CVD risk factors, HIV-related systemic inflammation, HAART treatment, and socioeconomic disadvantages often observed in this population.…”

Section: Hiv and Cvdmentioning

confidence: 99%

“…[27][28][29] Young black females in particular appear to be at an increased risk of ACS in the setting of HIV infection. 29,30 The reasons behind this observation may be multifactorial, inclusive of CVD risk factors, HIV-related systemic inflammation, HAART treatment, and socioeconomic disadvantages often observed in this population. 28,30 Our study found a higher incidence of AMI in black females as well.…”

Section: Hiv and Cvdmentioning

confidence: 99%

“…However, some of our findings have been reported in other countries. 2,29 Due to the nature of the database, long-term follow-up of these patients is not available.…”

Section: Management Of MI and Cvdmentioning

confidence: 99%

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Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction

Ogunbayo

Bidwell

Misumida

et al. 2018

Clinical Cardiology

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Hiv and Cvdmentioning

confidence: 99%

Section: Hiv and Cvdmentioning

confidence: 99%

“…However, some of our findings have been reported in other countries. 2,29 Due to the nature of the database, long-term follow-up of these patients is not available.…”

Section: Management Of MI and Cvdmentioning

confidence: 99%

See 3 more Smart Citations

Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction

Ogunbayo

Bidwell

Misumida

et al. 2018

Clinical Cardiology

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Circulating Microparticles Are Elevated in Treated HIV‐1 Infection and Are Deleterious to Endothelial Cell Function

Hijmans

Stockelman

Garcia

et al. 2019

JAHA

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Background Circulating microparticles have emerged as biomarkers and effectors of vascular disease. Elevated rates of cardiovascular disease are seen in HIV ‐1–seropositive individuals. The aims of this study were to determine: (1) if circulating microparticles are elevated in antiretroviral therapy–treated HIV ‐1–seropositive adults; and (2) the effects of microparticles isolated from antiretroviral therapy –treated HIV ‐1–seropositive adults on endothelial cell function, in vitro. Methods and Results Circulating levels of endothelial‐, platelet‐, monocyte‐, and leukocyte‐derived microparticles were determined by flow cytometry in plasma from 15 healthy and 15 antiretroviral therapy–treated, virologically suppressed HIV ‐1–seropositive men. Human umbilical vein endothelial cells were treated with microparticles from individual subjects for 24 hours; thereafter, endothelial cell inflammation, oxidative stress, senescence, and apoptosis were assessed. Circulating concentrations of endothelial‐, platelet‐, monocyte‐, and leukocyte‐derived microparticles were significantly higher (≈35%–225%) in the HIV ‐1–seropositive compared with healthy men. Microparticles from HIV ‐1–seropositive men induced significantly greater endothelial cell release of interleukin‐6 and interleukin‐8 (≈20% and ≈35%, respectively) and nuclear factor‐κB expression while suppressing anti‐inflammatory microRNAs (miR‐146a and miR‐181b). Intracellular reactive oxygen species production and expression of reactive oxygen species –related heat shock protein 70 were both higher in cells treated with microparticles from the HIV ‐1–seropositive men. In addition, the percentage of senescent cells was significantly higher and sirtuin 1 expression lower in cells treated with HIV ‐1–related microparticles. Finally, caspase‐3 was significantly elevated by microparticles from HIV ‐1–seropositive men. Conclusions Circulating concentrations of endothelial‐, platelet‐, monocyte‐, and leukocyte‐derived microparticles were higher in antiretroviral therapy–treated HIV ‐1–seropositive men and adversely affect endothelial cells promoting cellular inflammation, oxidative stress, senescence, and apoptosis. Circulating microparticles may contribute to the vascular risk associated with HIV ‐1 infection.

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Review of Cardiovascular Disease in HIV-Infected Women

Cited by 2 publications

References 50 publications

Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction

Sex differences in the contemporary management of HIV patients admitted for acute myocardial infarction

Circulating Microparticles Are Elevated in Treated HIV‐1 Infection and Are Deleterious to Endothelial Cell Function

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