Review of bimekizumab in the treatment of psoriasis

Koppu, Sindhuja; Singh, Rohan; Kaur, Kiranjit; Feldman, Steven R.

doi:10.1080/21645515.2022.2119767

Cited by 4 publications

(1 citation statement)

References 23 publications

(56 reference statements)

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“…The underlying pathogenesis involves dysregulated cutaneous immunity with dysfunction of T1 and T17 cells, dendritic cells, keratinocytes, fibroblasts, and macrophages. This results in keratinocyte hyperproliferation and the production of proinflammatory cytokines such as interleukin (IL)-17, IL-23, tumor necrosis factor-alpha (TNFα), and interferon-gamma (IFNγ) [ 1 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Risk of Cutaneous T Cell Lymphoma with Psoriasis Biologic Therapies

Davis,

Spencer,

Johnson

et al. 2023

Dermatol Ther (Heidelb)

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Background The risk of developing cutaneous T cell lymphoma (CTCL) in patients using psoriasis biologics has not been well characterized. The goals of this review were to investigate the incidence of CTCL in patients with psoriasis receiving biologic therapy in clinical trials and psoriasis registries, and to review cases of CTCL and biologic use reported in scientific publications. Methods The US National Library of Medicine clinical trials database (clinicaltrials.gov) was queried to identify phase 3 and 4 clinical trials of the 12 biologic agents currently FDA approved for psoriatic disease. The incidence of CTCL in these trials was examined and summarized. To examine the incidence of CTCL in psoriasis registries, a Medline search was conducted. Finally, we performed a systematic review of CTCL cases reported in the literature. Results Only two cases of CTCL were reported in 35,801 subjects with psoriasis receiving a biologic agent in the active arm of 108 psoriasis phase 3 clinical trials. One of these CTCL cases was determined by the investigator to be CTCL misdiagnosed as psoriasis prior to randomization. No cases of CTCL were reported in 5440 subjects with psoriasis in 34 phase 4 clinical trials. Only one case of CTCL was identified in 34,111 registry subjects. In the literature, tumor necrosis factor (TNF) inhibitors had the highest number of reported cases of CTCL (34 cases), followed by interleukin (IL)-17 inhibitors (7 cases), and IL-12/23 inhibitors (6 cases). No cases of CTCL were found to be reported with IL-23 inhibitors. Conclusion Our findings indicate that the development of CTCL is rare in the setting of psoriasis biologic use. Of the limited number of cases of CTCL found, most were in the setting of TNF inhibitor use and no cases of CTCL were reported in the setting of IL-23 inhibitor use. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-023-01074-z.

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Section: Introductionmentioning

confidence: 99%