Review of analytical and bioanalytical techniques for the determination of first-line anticytomegalovirus drugs

V., Ganesh; Sahini, K.; Basuri, P. Poorna; Nalini, C.N.

doi:10.1016/j.cjac.2022.100123

Cited by 2 publications

(2 citation statements)

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“…Valganciclovir (VGC) is a firstline antiviral drug that is used for the treatment of CMV infections. 1,2 After oral administration, it undergoes hydrolysis in the intestine by hepatic esterase, which is a hydrolase enzyme, and is rapidly converted into ganciclovir (i.e., VGC is a prodrug of ganciclovir). 3,4 This drug was approved by the Food and Drug Administration in the year 2001 for the treatment of CMV infections.…”

Section: Introductionmentioning

confidence: 99%

“…Cytomegalovirus (CMV) is a virus that is associated with serious conditions such as mononucleosis and hepatitis in immunocompromised patients. Valganciclovir (VGC) is a first-line antiviral drug that is used for the treatment of CMV infections. , After oral administration, it undergoes hydrolysis in the intestine by hepatic esterase, which is a hydrolase enzyme, and is rapidly converted into ganciclovir (i.e., VGC is a prodrug of ganciclovir). , This drug was approved by the Food and Drug Administration in the year 2001 for the treatment of CMV infections. The major side effect of VGC is a decrease in the function of bone marrow, which leads to a drop in the level of blood cells (e.g., RBCs, WBCs, and platelets) and a decrease in the body’s immune response.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Strip Sensor Based on a Silver Nanoparticle-Embedded Conducting Polymer for Sensitive In Vitro Detection of an Antiviral Drug

Kummari

Panicker

Gobi

et al. 2023

ACS Appl. Nano Mater.

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A straightforward and disposable electrochemical sensor was developed by the direct electrodeposition of silver nanoparticles (AgNPs) on a conducting polymer and an acidfunctionalized carbon nanotube-modified screen-printed carbon electrode (f-CNT/SPCE) for the detection of the antiviral drug valganciclovir (VGC). A scaffold layer of the conducting polymer 2,6-diaminopyridine (p-DAP) was electrodeposited on an f-CNT/ SPCE surface via a potentiodynamic polarization method. Later, homogeneous deposition of AgNPs was carried out on the polymer-modified scaffold layers. The electrode activities related to the concentration of the polymer substrate and the AgNP precursor were systematically optimized. The electrochemical oxidation of VGC by SPCE/f-CNT/p-DAP-AgNPs was investigated by square-wave voltammetry. The modified sensor exhibited an attractive electroanalytical performance toward VGC with high sensitivity (nanomolar range), selectivity (in the presence of uric acid and dopamine), reproducibility, and long-term storage stability. Potential real-world applications of the modified screen-printed sensor were demonstrated using artificial urine/serum and industrial water samples. The straightforward design and attractive analytical performance of the conductive polymer-embedded AgNP -modified screen-printed sensor suggest considerable promise for use of this sensor in the point-of-care screening of antiviral drugs. The sensor strip would also be useful in the screening of antiviral drugs in industrial (quality control) and environmental (industry effluents) applications.

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