Review of Amphotericin B for Invasive Fungal Infections in Neonates and Children

Abstract

Formulations of amphotericin B have come a long way since it was initially discovered. Studies of antifungals in the pediatric age-group are limited to those for cutaneous fungal infections. There are a few studies on the pharmacokinetics and safety of amphotericin B, and most dosage recommendations are extrapolated from adult data. A review of its use in the treatment of invasive fungal infections in neonates, children, and adolescents is the focus of this article.