Review of Adaptive Programmable Materials and Their Bioapplications

Fan, Xiaoshan; Chung, J. Y.; Lim, Yong Xiang; Liu, Yupeng; Loh, Xian Jun

doi:10.1021/acsami.6b09110

Cited by 117 publications

(104 citation statements)

References 131 publications

(196 reference statements)

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“…Without a solvent, sufficient temperature is required for movement of the polymer backbone, which allows for shape change associated with the return the entropic maximum that determines the primary shape of the material. In the presence of a solvent that can interrupt the hydrogen bonding, such as water or ethanol, the required temperature for the shape to change to occur is dramatically reduced, and shape recovery can be achieved at lower temperatures through the use of solvent as opposed to a purely thermally-driven recovery mechanism, due to the increased mobility of the crosslinking segments with disruption of the hydrogen bonded urethane and urea segments [40,41,48,49]. …”

Section: Discussionmentioning

confidence: 99%

Shape memory polyurethanes with oxidation-induced degradation: In vivo and in vitro correlations for endovascular material applications

et al. 2017

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The synthesis of thermoset shape memory polymer (SMP) polyurethanes from symmetric, aliphatic alcohols and diisocyanates has previously demonstrated excellent biocompatibility in short term in vitro and in vivo studies, although long term stability has not been investigated. Here we demonstrate that while rapid oxidation occurs in these thermoset SMPs, facilitated by the incorporation of multi-functional, branching amino groups, byproduct analysis does not indicate toxicological concern for these materials. Through complex multi-step chemical reactions, chain scission begins from the amines in the monomeric repeat units, and results, ultimately, in the formation of carboxylic acids, secondary and primary amines; the degradation rate and product concentrations were confirmed using liquid chromatography mass spectrometry, in model compound studies, yielding a previously unexamined degradation mechanism for these biomaterials. The rate of degradation is dependent on the hydrogen peroxide concentration, and comparison of explanted samples reveals a much slower rate in vivo compared to the widely accepted literature in vitro real-time equivalent of 3% H2O2. Cytotoxicity studies of the material surface, and examination of the degradation product accumulations, indicate that degradation has negligible impact on cytotoxicity of these materials.

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Section: Discussionmentioning

confidence: 99%

Shape memory polyurethanes with oxidation-induced degradation: In vivo and in vitro correlations for endovascular material applications

et al. 2017

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“…Amphiphilc star polymers with their hydrophobic cores are especially useful in encapsulating hydrophobic drugs to deliver into aqueous in vivo environments, which otherwise would be unachievable with free drug delivery alone . There are two primary methods for encapsulating hydrophobic drugs in micelles of star polymers, or micelles of any other polymers for that matter; the dialysis and the oil in water (o/w) emulsion methods.…”

Section: Properties Of Star‐shaped Polymersmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

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119

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With the advancement of polymer engineering, complex star-shaped polymer architectures can be synthesized with ease, bringing about a host of unique properties and applications. The polymer arms can be functionalized with different chemical groups to fine-tune the response behavior or be endowed with targeting ligands or stimuli responsive moieties to control its physicochemical behavior and self-organization in solution. Rheological properties of these solutions can be modulated, which also facilitates the control of the diffusion of the drug from these star-based nanocarriers. However, these star-shaped polymers designed for drug delivery are still in a very early stage of development. Due to the sheer diversity of macromolecules that can take on the star architectures and the various combinations of functional groups that can be cross-linked together, there remain many structure-property relationships which have yet to be fully established. This review aims to provide an introductory perspective on the basic synthetic methods of star-shaped polymers, the properties which can be controlled by the unique architecture, and also recent advances in drug delivery applications related to these star candidates.

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“…Poly(lactic acid) (PLA), an important bioplastic, has attracted wide attention due to its good biocompatibility and biodegradability. In addition, PLA is a good biomedical polymer material with wide application in tissue engineering, human organs, controlled drug release, bionic intelligent materials, etc . However, PLA also has some shortcomings such as a relatively low glass transition temperature of about 60 °C and poor toughness.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the crystallization behavior of poly(ethylene glycol) and stereocomplex crystallization of poly(L‐lactic acid)/poly(D‐lactic acid)

Luo

Yang

Xiao

et al. 2018

Polymer International

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Poly(l‐lactic acid) (PLLA) is a good biomedical polymer material with wide applications. The addition of poly(ethylene glycol) (PEG) as a plasticizer and the formation of stereocomplex crystals (SCs) have been proved to be effective methods for improving the crystallization of PLLA, which will promote its heat resistance. In this work, the crystallization behavior of PEG and PLLA/poly(d‐lactic acid) (PDLA) in PLLA/PDLA/PEG and PEG‐b‐PLLA/PEG‐b‐PDLA blends has been investigated using differential scanning calorimetry, polarized optical microscopy and X‐ray diffraction. Both SCs and homocrystals (HCs) were observed in blends with asymmetric mass ratio of PLLA/PDLA, while exclusively SCs were observed in blends with approximately equal mass ratio of PLLA/PDLA. The crystallization of PEG was only observed for the symmetric blends of PLLA39k/PDLA35k/PEG2k, PLLA39k/PDLA35k/PEG5k, PLLA69k/PDLA96k/PEG5k and PEG‐b‐PLLA31k/PEG‐b‐PDLA27k, where the mass ratio of PLLA/PDLA was approximately 1/1. The results demonstrated that the formation of exclusively SCs would facilitate the crystallization of PEG, while the existence of both HCs and SCs could restrict the crystallization of PEG. The crystallization of PEG is related to the crystallinity of PLLA and PDLA, which will be promoted by the formation of SCs. © 2017 Society of Chemical Industry

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Review of Adaptive Programmable Materials and Their Bioapplications

Cited by 117 publications

References 131 publications

Shape memory polyurethanes with oxidation-induced degradation: In vivo and in vitro correlations for endovascular material applications

Shape memory polyurethanes with oxidation-induced degradation: In vivo and in vitro correlations for endovascular material applications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Relationship between the crystallization behavior of poly(ethylene glycol) and stereocomplex crystallization of poly(L‐lactic acid)/poly(D‐lactic acid)

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