“…57 Monitoring of ICP in patients at risk of developing ACS has no significant complications, but failure to monitor may lead to a missed diagnosis. 2,10 The critical pressure that will lead to microcirculatory failure depends on the patient's blood pressure, the duration of pressure elevation, and many other local and systemic factors. 44 Both basic science and clinical studies have shown that muscle ischaemia in injured limbs generally occurs when the tissue pressure increases to within 20e30 mmHg of the diastolic pressure.…”