Review: MicroRNAS in ocular surface and dry eye diseases

Rassi, Diane Meyre; Paiva, Cintia S. de; Dias, Lara Cristina; Módulo, Carolina Maria; Adriano, Leidiane; Fantucci, Marina Zílio; Rocha, Eduardo Melani

doi:10.1016/j.jtos.2017.05.007

Cited by 31 publications

(17 citation statements)

References 107 publications

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“…SS dry eye is a multifactorial disease, including genetic predisposition, environmental and epigenetic factors [12]. Recently, accumulating evidences have revealed that miRs are dysregulated in tears, PBMCs, and salivary gland of patients with SS [15,17,24]. Nevertheless, the miRs profiling in LGs of SS dry eye remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

et al. 2020

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Purpose: To identify the differential expression of microRNAs (miRs) and the related gene networks and signal pathways in lacrimal glands (LGs) of rabbit autoimmune dacryoadenitis. Methods: Autoimmune dacryoadenitis in rabbits was induced by transferring activated peripheral blood lymphocytes (PBLs). The LGs of normal and model group rabbits were collected for small RNA sequencing. The most differentially expressed miRs were validated by quantitative real time-polymerase chain reaction (qRT-PCR). Further, bioinformatics analysis including target gene prediction, Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Results: A total of 15 miRs were differentially expressed in the LGs of rabbit autoimmune dacryoadenitis relative to normal controls. GO and KEGG analysis revealed that most target genes of these dysregulated miRs were implicated in MAPK signaling pathway. Conclusion: Our results showed for the first time the differentially expressed miRs and the related pathways involved in the pathogenesis of rabbit autoimmune dacryoadenitis. These results may contribute to elucidating molecular pathogenesis of Sjögren's syndrome (SS) dry eye.

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Section: Discussionmentioning

confidence: 99%

“…For example, Shi et al demonstrated that the expression of miR-146a is upregulated and miR-155 is downregulated in PBMCs of patients with SS, and the expression levels of these miRs are correlated with the visual analog scale scores for dry eye [16]. However, little is known about the miRs expression profile in LGs of SS dry eye [17].…”

Section: Ivyspringmentioning

confidence: 99%

MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

et al. 2020

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“…Non-coding RNAs (ncRNAs), such as microRNA (miRNA), long non-codingRNA (lncRNA) and circlar RNA (circRNA), are a large category of functional RNA molecules involved in regulating many biological processes (Esteller, 2011). Numerous studies demonstrated that ncRNAs play important roles in various EDs (Li et al, 2016;Rassi et al, 2017;Zhang et al, 2017). For example, the lncRNA PVT1 is up-regulated in RB tissues and silencing PVT1 can suppress the tumor growth (Wu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nc2Eye: A Curated ncRNAomics Knowledgebase for Bridging Basic and Clinical Research in Eye Diseases

Zhang

Xue

Guo

et al. 2020

Front. Cell Dev. Biol.

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Eye diseases (EDs) represent a group of disorders affecting the visual system, most of which can lead to visual impairment and blindness. Accumulating evidence reveals that non-coding RNAs (ncRNAs) are closely associated with a wide variety of EDs. However, abundant associations between ncRNAs and EDs are scattered across the published literature, obstructing a global view of ncRNA-ED associations. A public resource of high-quality manually curated ncRNAomics knowledge associated with EDs remains unavailable. To address this gap, we thus developed Nc2Eye (http://nc2eye. bio-data.cn/), which is the first knowledgebase dedicated to providing a comprehensive ncRNAomics resource for bridging basic and clinical research in EDs. Through a comprehensive review of more than 2400 published papers, Nc2Eye catalogs 7088 manually curated ncRNA-ED associations involving 4363 ncRNAs across eight species. We also provide detailed descriptions and annotation information for each ncRNAdisease association such as ncRNA categories, experimental methods, expression pattern and related clinical drugs. To further expand the pathogenic ncRNAs, we also collected more than 90 high-throughput EDs-related transcriptome datasets. Furthermore, a user-friendly interface was constructed for convenient and flexible data browsing, querying, and retrieving. We believe that Nc2Eye is a timely and valuable knowledgebase for significantly improving and useful for discovery of new diagnostic and therapeutic biomarkers.

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“…To date, numbers of miRNAs have been discovered in different organisms, and diverse roles of these miRNAs have been described in physiological or pathological conditions . It has been reported that humans have approximately 1000 miRNAs that can interfere with approximately 30% of gene expression, mostly as gene suppressors (Rassi et al, 2017). MiRNAs play crucial roles in the development and progression of human cancers, such as hepatocellular carcinoma (Lang and Ling, 2012).…”

Section: Introductionmentioning

confidence: 99%

MiR-124 involvement of apoptosis, immunity and regulator of diseases

Sun¹,

Huang²,

Yu³

et al. 2020

Afr. J. Biotechnol.

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Most microRNAs (miRNAs) are noncoding, conserved RNA molecules in vertebrates, and their roles are similar and very important. MiRNAs usually have tissue-specific expression, and abnormal levels of miRNAs have been associated with diseases and have been used as disease biomarkers. MiRNAs are widely involved in biological processes by regulating target mRNAs. MiR-124 is one of the best studied miRNAs in organisms. By targeting different mRNAs, miR-124 plays important roles in the central nervous system, cellular infiltration, pathophysiological processes of cardiovascular diseases, inflammation, immunity and tolerance, etc. This review mainly focuses on tissue-specific or abnormal expression of miR-124 as a biomarker and on the ways miR-124 for the treatment of serious diseases such as cancers.

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Review: MicroRNAS in ocular surface and dry eye diseases

Cited by 31 publications

References 107 publications

MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

Nc2Eye: A Curated ncRNAomics Knowledgebase for Bridging Basic and Clinical Research in Eye Diseases

MiR-124 involvement of apoptosis, immunity and regulator of diseases

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