Review: Maintenance of the ruminant corpus luteum during pregnancy: interferon-tau and beyond

Wiltbank, Milo C.; Monteiro, P. L. J.; Domingues, Rafael R.; Andrade, João Paulo N.; Mezera, M.A.

doi:10.1016/j.animal.2023.100827

Cited by 8 publications

(4 citation statements)

References 75 publications

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“…IFNT helps maintain the corpus luteum function and regulates the maternal immune system to ensure embryo implantation (Bai et al, 2022;Martal et al, 1990;Talukder et al, 2017). IFNT has been shown to act in a paracrine manner on the endometrium by inhibiting the secretion of prostaglandin F2α (PGF2α), which prevents the lysis of the corpus luteum, ensuring that the ovarian corpus luteum continues to produce progesterone (Spencer et al, 2007;Wiltbank et al, 2023). IFNT can alter the transcriptome of the maternal endometrium early in pregnancy, increasing genetic expression that is known to promote embryo development and establish uterine receptivity to the embryo (Spencer et al, 2008).…”

Section: Ifnt and Isg Smentioning

confidence: 99%

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Gui,

Dai,

Guo

et al. 2024

Reprod Domestic Animals

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Early pregnancy loss is a primary cause of low reproductive rates in dairy cows, posing severe economic losses to dairy farming. The accurate diagnosis of dairy cows with early pregnancy loss allows for oestrus synchronization, shortening day open, and increasing the overall conception rate of the herd. Several techniques are available for detecting early pregnancy loss in dairy cows, including rectal ultrasound, circulating blood progesterone, and pregnancy‐associated glycoproteins (PAGs). Yet, there is a need to improve on existing techniques and develop novel strategies to identify cows with early pregnancy loss accurately. This manuscript reviews the applications of rectal ultrasound, circulating blood progesterone concentration, and PAGs in the diagnosis of pregnancy loss in dairy cows. The manuscript also discusses the recent progress of new technologies, including colour Doppler ultrasound (CDUS), interferon tau‐induced genes (ISGs), and exosomal miRNA in diagnosing pregnancy loss in dairy cows. This study will provide an option for producers to re‐breed cows with pregnancy loss, thereby reducing the calving interval and economic costs. Meanwhile, this manuscript might also act as a reference for exploring more economical and precise diagnostic technologies for early pregnancy loss in dairy cows.

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Section: Ifnt and Isg Smentioning

confidence: 99%

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Gui,

Dai,

Guo

et al. 2024

Reprod Domestic Animals

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“…A drawback of both P4 and PAG analysis is that the concentrations may remain high for some time after the embryo or fetus has died. There may be continued P4 production from the corpus luteum before it is fully luteolyzed (e.g., Wiltbank et al, 2023), and the long half-life of the PAG effectively means that it takes 7-14 days for the concentration to break down and decrease in circulation . Thus the cow can still test positive during this period .…”

Section: Differences and Similarities Between Automated Recording Of ...mentioning

confidence: 99%

Genetics of new phenotypes of pregnancy loss in dairy cattle

Ask Gullstrand

2024

Acta Universitatis Agriculturae Sueciae

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This thesis examined use of novel phenotypes of pregnancy loss to improve genetic progress in female fertility in dairy cattle. Genomic information was used to identify candidate genes associated with pregnancy loss traits, and to estimate the extent and effect of genetic defects on pregnancy outcome. Automatically recorded progesterone (P4) data from 14 Herd NavigatorTM herds and pregnancy-associated glycoprotein (PAG) levels recorded in 1119 herds affiliated to the Swedish milk recording scheme were used to evaluate embryo, fetal and total pregnancy loss. The extent of pregnancy loss was considerable according to both diagnosis methods, ranging from 30 to 60%. In most cases, Swedish Red cows showed better pregnancy maintenance than Swedish Holstein. The P4 and PAG concentrations in milk were significantly lower in initially pregnant cows after losing their pregnancy compared with full-term pregnant cows, which indicates the importance of continuously high P4 and PAG levels during gestation to support embryo and fetus development. Similarly to calving and insemination-based fertility traits, heritability estimates of pregnancy loss traits were low (0.00-0.07). A single-step genome-wide association study identified 19 candidate genes associated with pregnancy loss traits, several of which are known to influence embryonic and fetal development. Mating two carriers of genetic defects adversely affected fertility and caused 14-15% higher mortality compared with non-carrier matings. Considering pregnancy loss in future routine genetic and genomic evaluations of fertility in dairy cattle could genetically improve cow fertility by reducing pregnancy losses in milk production, while also preventing economic losses arising from extended service period and calving interval, and involuntary culling due to infertility.

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“…Although the mechanisms regulating the formation and regression of the bovine CL during the estrous cycle have been well studied, few studies have been conducted on the CL during the entire gestational period. Recently, an excellent review of functional changes in the CL during pregnancy was published [ 37 ]. Readers are referred to that review for details, whereas this review focuses on and discusses the expression of chemokines and their role in bovine CL during pregnancy.…”

Section: Chemokine Expression and Its Role In The Bovine CL During Pr...mentioning

confidence: 99%

Role of chemokines in regulating luteal and uterine functions in pregnant cows

SAKUMOTO

2024

Journal of Reproduction and Development

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Pregnancy is intricately regulated by the interactions between various bioactive substances secreted by the conceptus, uterus, and corpus luteum (CL). Interferon-τ, synthesized and secreted by the conceptus, plays a central role in the interaction mechanism of maternal recognition in cows. Chemokines, chemotaxis mediators that are primarily secreted by immune cells, regulate various reproductive responses in various species. Although there are scattered reports on the potential roles of chemokines in the bovine CL and the uterus during the estrous cycle, there is little information on chemokines in these organs during pregnancy. Therefore, in this review, we discuss the possible physiological roles of chemokines in the CL and uterus of pregnant cows, focusing on our recent findings on chemokines and changes in their receptor expression in the CL and endometrium of cows at some stages of pregnancy.

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Review: Maintenance of the ruminant corpus luteum during pregnancy: interferon-tau and beyond

Cited by 8 publications

References 75 publications

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Genetics of new phenotypes of pregnancy loss in dairy cattle

Role of chemokines in regulating luteal and uterine functions in pregnant cows

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