Review: Maintenance of the ruminant corpus luteum during pregnancy: interferon-tau and beyond

Wiltbank, Milo C.; Monteiro, P. L. J.; Domingues, Rafael R.; Andrade, João Paulo N.; Mezera, M.A.

doi:10.1016/j.animal.2023.100827

Cited by 7 publications

(3 citation statements)

References 75 publications

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“…IFNT helps maintain the corpus luteum function and regulates the maternal immune system to ensure embryo implantation (Bai et al, 2022;Martal et al, 1990;Talukder et al, 2017). IFNT has been shown to act in a paracrine manner on the endometrium by inhibiting the secretion of prostaglandin F2α (PGF2α), which prevents the lysis of the corpus luteum, ensuring that the ovarian corpus luteum continues to produce progesterone (Spencer et al, 2007;Wiltbank et al, 2023). IFNT can alter the transcriptome of the maternal endometrium early in pregnancy, increasing genetic expression that is known to promote embryo development and establish uterine receptivity to the embryo (Spencer et al, 2008).…”

Section: Ifnt and Isg Smentioning

confidence: 99%

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Gui,

Dai,

Guo

et al. 2024

Reprod Domestic Animals

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Early pregnancy loss is a primary cause of low reproductive rates in dairy cows, posing severe economic losses to dairy farming. The accurate diagnosis of dairy cows with early pregnancy loss allows for oestrus synchronization, shortening day open, and increasing the overall conception rate of the herd. Several techniques are available for detecting early pregnancy loss in dairy cows, including rectal ultrasound, circulating blood progesterone, and pregnancy‐associated glycoproteins (PAGs). Yet, there is a need to improve on existing techniques and develop novel strategies to identify cows with early pregnancy loss accurately. This manuscript reviews the applications of rectal ultrasound, circulating blood progesterone concentration, and PAGs in the diagnosis of pregnancy loss in dairy cows. The manuscript also discusses the recent progress of new technologies, including colour Doppler ultrasound (CDUS), interferon tau‐induced genes (ISGs), and exosomal miRNA in diagnosing pregnancy loss in dairy cows. This study will provide an option for producers to re‐breed cows with pregnancy loss, thereby reducing the calving interval and economic costs. Meanwhile, this manuscript might also act as a reference for exploring more economical and precise diagnostic technologies for early pregnancy loss in dairy cows.

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Section: Ifnt and Isg Smentioning

confidence: 99%

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Gui,

Dai,

Guo

et al. 2024

Reprod Domestic Animals

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“…Although the mechanisms regulating the formation and regression of the bovine CL during the estrous cycle have been well studied, few studies have been conducted on the CL during the entire gestational period. Recently, an excellent review of functional changes in the CL during pregnancy was published [ 37 ]. Readers are referred to that review for details, whereas this review focuses on and discusses the expression of chemokines and their role in bovine CL during pregnancy.…”

Section: Chemokine Expression and Its Role In The Bovine CL During Pr...mentioning

confidence: 99%

Role of chemokines in regulating luteal and uterine functions in pregnant cows

SAKUMOTO

2024

Journal of Reproduction and Development

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Pregnancy is intricately regulated by the interactions between various bioactive substances secreted by the conceptus, uterus, and corpus luteum (CL). Interferon-τ, synthesized and secreted by the conceptus, plays a central role in the interaction mechanism of maternal recognition in cows. Chemokines, chemotaxis mediators that are primarily secreted by immune cells, regulate various reproductive responses in various species. Although there are scattered reports on the potential roles of chemokines in the bovine CL and the uterus during the estrous cycle, there is little information on chemokines in these organs during pregnancy. Therefore, in this review, we discuss the possible physiological roles of chemokines in the CL and uterus of pregnant cows, focusing on our recent findings on chemokines and changes in their receptor expression in the CL and endometrium of cows at some stages of pregnancy.

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“…This hormone plays a key role in conceptus development, uterine receptivity, and the establishment and maintenance of pregnancy through its effects on oocyte quality and the uterine endometrium. Numerous studies have demonstrated that elevated concentrations of circulating P4 in the period immediately following conception are associated with advancement in conceptus elongation, increased IFNt production, and higher pregnancy rates; conversely, low P4 concentrations are associated with reductions in conceptus growth and elongation, decreased IFNt production, and lower pregnancy rates [29][30][31]. Therefore, there is a close relationship between P4 and IFNt in the delicate phase of the peri-implantation period.…”

Section: Introductionmentioning

confidence: 99%

Interferon-Tau in Maternal Peripheral Blood and Its Relationship with Progesterone and Pregnancy-Associated Glycoproteins in the Early Phases of Gestation in Water Buffalo

Barbato,

Menchetti,

Casano

et al. 2024

Animals

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The aim of this study was to investigate the interferon tau (IFNt) concentration in the peripheral maternal blood during the early phase of pregnancy in buffalo cows and improve the knowledge on the physiological importance of circulating IFNt, evaluating the possible interaction with pregnancy-associated glycoproteins (PAGs) and progesterone (P4). Blood samples were taken from buffalo cows on day 0 (day of AI), 7, 14, 18, 28, and 40 post insemination for the IFNt, PAG, and P4 analysis and to determine the IFNt mRNA expression. The animals were categorized ex post into Pregnant, Non-pregnant and Embryo mortality groups. The interferon value was influenced by group (p = 0.003), being always higher in pregnant buffalo cows than in non-pregnant ones, while the embryo mortality group showed intermediate values between those for pregnant and non-pregnant animals. The mRNA expression of IFNt was not influenced by groups or any time points. The regression analysis that included IFNt as the independent variable showed that PAGs, from day 18 (p < 0.01), and P4, from day 28 (p < 0.05), were positively associated with IFNt values. The close associations among IFNt, PAGs and P4 demonstrate that all three molecules work together for fetal–placental well-being and pregnancy support. Unfortunately, the great individual variability in circulating IFNt makes this analysis unsuitable for early pregnancy diagnosis.

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Review: Maintenance of the ruminant corpus luteum during pregnancy: interferon-tau and beyond

Cited by 7 publications

References 75 publications

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Recent advances in early pregnancy loss diagnosis in dairy cows: New approaches

Role of chemokines in regulating luteal and uterine functions in pregnant cows

Interferon-Tau in Maternal Peripheral Blood and Its Relationship with Progesterone and Pregnancy-Associated Glycoproteins in the Early Phases of Gestation in Water Buffalo

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