Review – Late toxicity of abdominal and pelvic radiotherapy for childhood cancer

Hessels, Arno; Langendijk, Johannes A.; Gawryszuk, A.; Heersters, Mart A.A.M.; Salm, Nathalie L.M. van der; Tissing, Wim J. E.; Weide, H. L. van der; Maduro, John H.

doi:10.1016/j.radonc.2022.02.029

Cited by 6 publications

(2 citation statements)

References 104 publications

(208 reference statements)

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“…Over the years, radiotherapy has been developing as a crucial modality used in first‐line treatment of cancer 3 . However, RT can also bring toxicity to patients, 11,18,19 of which RT‐associated secondary cancer from radiotherapy of primary cancer cannot be neglected 13,20 . In previous literature, RT have been widely regarded as significant risk factor for secondary pelvic neoplasms 15,21 .…”

Section: Discussionmentioning

confidence: 99%

Risk and prognosis of secondary thoracic cancers after radiation therapy for esophageal cancer

Lin

et al. 2023

J of Gastro and Hepatol

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Background and Aim Radiation therapy (RT) is a crucial modality for the local control of esophageal cancer (EC), but the effect of RT on the development of secondary thoracic malignancies is still unclear. This study aims to identify the association between RT for the treatment of primary EC and subsequent secondary thoracic cancer (STC). Methods The primary EC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Fine‐Gray competing risk regression and standardized incidence ratio (SIR) were used to evaluate the radiotherapy‐associated cancer risk. Overall survival (OS) was compared by Kaplan–Meier analysis. Results A total of 40 255 EC patients from the SEER database were identified, of which 17 055 patients (42.37%) did not receive radiotherapy (NRT) and 23 200 patients (57.63%) had been treated with RT. After 12 months of latency, 162 patients (0.95%) in the NRT group and 272 patients (1.17%) in the RT group developed STC. The incidences of the RT group were significantly higher than the NRT group. Patients who have primary EC were at an increased risk of developing STC (SIR = 1.79, 95% CI: 1.63–1.96). The SIR of STC was 1.37 (95% CI: 1.16–1.60) in the NRT group and 2.10 (95% CI: 1.87–2.34) in the RT group. The OS of STC patients in the RT group was significantly lower than the NRT group (P = 0.006). Conclusion The RT for primary EC was associated with higher risks of developing STC than patients unexposed to radiotherapy. The EC patients treated with RT, especially young patients, require long‐term monitoring of the risk of STC.

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Section: Discussionmentioning

confidence: 99%

Risk and prognosis of secondary thoracic cancers after radiation therapy for esophageal cancer

Lin

et al. 2023

J of Gastro and Hepatol

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“…Ovarian failure has been reported in 90% of patients followed up long term after total body irradiation (10-15 Gy, ~2 Gy per fraction), and in 97% of the females treated with fractionated total abdominal irradiation (20-30 Gy, 1-2 Gy per fraction) during childhood ( Meirow et al, 2010 ; Wallace et al, 1989 ). Young patients treated with chemotherapy or radiotherapy, who can expect a normal life span, may suffer significant damage to the ovary ( Hessels et al, 2022 ; Levine et al, 2018 ; Lo Presti et al, 2004 ). Consequently, early and late effects after treatment are gaining greater importance for survivors and their families ( Tonorezos et al, 2022 ; Yurut-Caloglu et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of nuclear maturation, DNA damage and repair gene expression of bovine oocyte and cumulus cells submitted to ionizing radiation

et al. 2023

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Radiotherapy causes destruction of tumor cells, but also threatens the integrity and survival of surrounding normal cells. Then, woman submitted to irradiation for cancer treatment may present permanent ovary damage, resulting in impaired fertility. The objective of this study was to investigate the effects of therapeutic doses of ionizing radiation (IR), used for ovarian cancer treatment in humans, on bovine cumulus-oocyte complexes (COCs) as experimental model. Bovine ovaries were exposed to 0.9 Gy, 1.8 Gy, 3.6 Gy or 18.6 Gy IR, and then COCs were collected and used to evaluate: (a) oocyte nuclear maturation; (b) presence of phosphorylated H2A.X (γH2AX), as an indicator of DNA double-strand breaks (DSBs); and (c) expression of genes involved in DNA repair ( TP53BP1, RAD52, ATM, XRCC6 and XRCC5 ) and apoptosis ( BAX ). The radiation doses tested in this study had no detrimental effects on nuclear maturation and did not increase γH2AX in the oocytes. However, IR treatment altered the mRNA abundance of RAD52 (RAD52 homolog, DNA repair protein) and BAX (BCL2-associated X protein). We conclude that although IR doses had no apparent effect on oocyte nuclear maturation and DNA damage, molecular pathways involved in DNA repair and apoptosis were affected by IR exposure in cumulus cells.

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Correlation between plasma lycopene levels in patients with laryngeal carcinoma and postoperative adverse complications of chemoradiotherapy and nutritional risks

Wang,

Chen

et al. 2023

Eur Arch Otorhinolaryngol

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Review – Late toxicity of abdominal and pelvic radiotherapy for childhood cancer

Cited by 6 publications

References 104 publications

Risk and prognosis of secondary thoracic cancers after radiation therapy for esophageal cancer

Risk and prognosis of secondary thoracic cancers after radiation therapy for esophageal cancer

Analysis of nuclear maturation, DNA damage and repair gene expression of bovine oocyte and cumulus cells submitted to ionizing radiation

Correlation between plasma lycopene levels in patients with laryngeal carcinoma and postoperative adverse complications of chemoradiotherapy and nutritional risks

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