Review: Impact of <i>Helicobacter pylori</i> on Alzheimer's disease: What do we know so far?

Doulberis, Michael; Kotronis, Georgios; Thomann, Robert V.; Polyzos, Stergios A.; Boziki, Marina; Gialamprinou, Dimitra; Deretzi, Georgia; Katsinelos, Panagiotis; Kountouras, Jannis

doi:10.1111/hel.12454

Cited by 104 publications

(106 citation statements)

References 252 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…H. pylori induces other diseases of the alimentary tract, including gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma, GERD symptoms, and dyspepsia [41][42][43][44][45][46]. There is an increasing interest in the role of H. pylori in the pathogenesis of ischemic heart disease, diabetes mellitus, and Alzheimer's disease [47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Baj

Korona-Głowniak

Forma

et al. 2020

Cells

117

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of the world's population. Approximately 20% of the infected patients develop gastric ulcers or neoplastic changes in the gastric stroma. An infection also leads to the progression of epithelial-mesenchymal transition within gastric tissue, increasing the probability of gastric cancer development. This paper aims to review the role of H. pylori and its virulence factors in epithelial-mesenchymal transition associated with malignant transformation within the gastric stroma. The reviewed factors included: CagA (cytotoxin-associated gene A) along with induction of cancer stem-cell properties and interaction with YAP (Yes-associated protein pathway), tumor necrosis factor α-inducing protein, Lpp20 lipoprotein, Afadin protein, penicillin-binding protein 1A, microRNA-29a-3p, programmed cell death protein 4, lysosomal-associated protein transmembrane 4β, cancer-associated fibroblasts, heparin-binding epidermal growth factor (HB-EGF), matrix metalloproteinase-7 (MMP-7), and cancer stem cells (CSCs). The review summarizes the most recent findings, providing insight into potential molecular targets and new treatment strategies for gastric cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Baj

Korona-Głowniak

Forma

et al. 2020

Cells

117

View full text Add to dashboard Cite

show abstract

“…Hp selectively infects and colonizes mostly the gastric epithelium, oral cavity, and intestinal epithelium. It is strongly involved in the development of several pathologies, particularly in the upper or lower gastrointestinal tracts, and a variety of systemic disorders and neurodegenerative diseases, such as Alzheimer's disease (AD) and glaucoma . Behaving as microbiota, Hp and its virulent products induce lasting chronic gastrointestinal inflammatory processes and systemic inflammatory reactions by orchestrating and modifying the character of immune system responses.…”

Section: Hp In No‐related Glaucoma Pathophysiologymentioning

confidence: 99%

“…Behaving as microbiota, Hp and its virulent products induce lasting chronic gastrointestinal inflammatory processes and systemic inflammatory reactions by orchestrating and modifying the character of immune system responses. Therefore, it contributes to the pathophysiology of gastrointestinal and systemic disorders …”

Section: Hp In No‐related Glaucoma Pathophysiologymentioning

confidence: 99%

See 1 more Smart Citation

Impact of nitric oxide's bidirectional role on glaucoma: focus onHelicobacter pylori–related nitrosative stress

Papaefthymiou

Doulberis

Katsinelos

et al. 2019

Annals of the New York Academy of Sciences

Self Cite

View full text Add to dashboard Cite

Nitric oxide (NO), a small molecule generated ubiquitously, targets a plethora of tissues to regulate both physiological and pathophysiological functions. NO overproduction, stimulated by microenvironmental conditions, is the main component that dysregulates the tight balance between its beneficial and damaging roles in ocular homeostasis. Considering the protective functions of NO against glaucoma, its endogenous release facilitates aqueous humor drainage and regulates ocular blood flow, maintaining a normal intraocular pressure. NO overproduction generates free radicals, such as peroxynitrite, which induce a vicious circle of vascular disharmony and dysregulation, transient ischemia, nitrosative stress, neuronal degeneration, and permanent glaucomatic injury. Helicobacter pylori (Hp) is considered a burdening factor of glaucoma. NO overproduction and possible systematic dispersion in Hp infection (Hp‐I) could suggest a potential pathophysiological bridge between these conditions. In this review, we aim to elucidate the role of NO in glaucoma with respect to Hp‐I, with the aim to stimulate further studies.

show abstract

“…According to current guidelines [10], peptic ulcer disease, gastritis, gastric atrophy, gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma, idiopathic thrombocytopenic purpura or iron-deficiency anemia necessitate a Hp test and treat strategy, whereas a plethora of further disorders have been connected with Hp-I, such as colorectal cancer and esophageal adenocarcinoma. In certain subpopulations, insulin resistance, non-alcoholic liver disease, and neurodegenerative conditions have also been associated with Hp-I [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?

et al. 2020

Self Cite

View full text Add to dashboard Cite

Helicobacter pylori (Hp) management has undoubtedly resulted in a notable economic burden on healthcare systems globally, including Greece. Its cost has never been estimated so far, especially during the recent 10-year unprecedented financial crisis. Direct medical and procedural costs for one attempt “outpatient” Hp eradication treatment were estimated as the following: (I) first-line regimens: 10 and 14 days standard triple, 10 and 14 days sequential, 10 and 14 days concomitant non-bismuth quadruple, 14 days hybrid, (II) second-line salvage regimens: 10 and 14 days levofloxacin-containing triple regimens. Treatment costs using prototypes and/or generic drugs were calculated. Drug prices were collected and confirmed from two official online medical databases including all medicines approved by the Greek National Organization for Medicines. Regimens based on generics were more affordable than prototypes and those including pantoprazole yielded the lowest prices (mean: 27.84 €). Paradoxically, 10-day concomitant and 14-day hybrid regimens (currently providing good (90–94%) first-line eradication rates in Greece) cost the same (mean: 34.76 €). The expenditures for Hp eradication treatment regimens were estimated thoroughly for the first time in Greece. These data should be taken into account by Public Health policymakers both in Greece and the European Union, aiming for a better and less expensive therapeutic approach.

show abstract

Review: Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

Abstract: Background: Helicobacter pylori has changed radically gastroenterologic world, offer-

Cited by 104 publications

References 252 publications

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Impact of nitric oxide's bidirectional role on glaucoma: focus onHelicobacter pylori–related nitrosative stress

Evaluation of the Direct Economic Cost per Eradication Treatment Regimen against Helicobacter pylori Infection in Greece: Do National Health Policy-Makers Need to Care?

Contact Info

Product

Resources

About