Review: <i>Regional Imperative: The Administration of U.S. Foreign Policy towards South Asian States under Presidents Johnson and Nixon</i>, by Lloyd I. Rudolph and Susanne Hoeber Rudolph

Swomley, John M.

doi:10.2307/3639104

Cited by 1 publication

(1 citation statement)

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“…This group shows GO enrichment for proteins associated with the oxidation-reduction process with 14 proteins included in that grouping and many others involved in other aspects of metabolism. It has been shown previously that the functionality of antioxidants and therefore mediation of oxidative stress can be associated with AD [42][43][44] and that these effects can vary significantly by region with age and potentially neurodegeneration [45].…”

Section: Differentially Expressed Proteinsmentioning

confidence: 99%

Proteomic Atlas of the Human Brain in Alzheimer’s Disease

McKetney¹,

Runde²,

Hebert³

et al. 2019

J. Proteome Res.

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The brain represents one of the most divergent and critical organs in the human body. Yet, it can be afflicted by a variety of neurodegenerative diseases specifically linked to aging, about which we lack a full biomolecular understanding of onset and progression, such as Alzheimer's Disease (AD). Here we provide a proteomic resource comprising nine anatomically distinct sections from three aged individuals, across a spectrum of disease progression, categorized by quantity of neurofibrillary tangles. Using state-of-the-art mass spectrometry, we identify a core brain proteome that exhibits only small variance in expression, accompanied by a group of proteins that are highly differentially expressed in individual sections and broader regions. AD affected tissue exhibited slightly elevated levels of tau protein with similar relative expression to factors associated with the AD pathology. Substantial differences were identified between previous proteomic studies of mature adult brains and our aged cohort. Our findings suggest considerable value in examining specifically the brain proteome of aged human populations from a multiregional perspective. This resource can serve as a guide, as well as a point of reference for how specific regions of the brain are affected by aging and neurodegeneration.

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