Review: Gastric cancer: Basic aspects

Resende, Carlos; Gomes, Carla Pereira; Machado, José Carlos

doi:10.1111/hel.12739

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Multiple genes are associated with gastric tumorigenesis [ 17 , 18 ]. In an effort to identify the genes responsible for the tumorigenesis of GC, we performed a genome-wide gene expression analysis of human GC and adjacent normal tissues from 27 Korean GC patients (NCBI GEO accession GSE30727) [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Lee,

Hwang,

Hong

et al. 2024

Genom. Inform.

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Here, we investigated that the heat shock protein 47 (HSP47) plays a crucial role in the progression of gastric cancer (GC). We analyzed HSP47 gene expression in GC cell lines and patient tissues. The HSP47 mRNA and protein expression levels were significantly higher in GC cell lines and tumor tissues compared to normal gastric mucosa. Using siRNA to silence the expression of HSP47 in GC cells resulted in a significant reduction in their proliferation, wound healing, migration, and invasion capacities. Additionally, we also showed that the mRNA expression of matrix metallopeptidase-7 (MMP-7), a metastasis-promoting gene, was significantly reduced in HSP47 siRNA-transfected GC cells. We confirmed that the HSP47 promoter region was methylated in the SNU-216 GC cell line expressing low levels of HSP47 and in most non-cancerous gastric tissues. It means that the expression of HSP47 is regulated by epigenetic regulatory mechanisms. These findings suggest that targeting HSP47, potentially through its promoter methylation, could be a useful new therapeutic strategy for treating GC.

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Section: Discussionmentioning

confidence: 99%

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Lee,

Hwang,

Hong

et al. 2024

Genom. Inform.

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“…However, decoding the mechanisms of GC is of vital importance, as the molecular pathogenesis of GC has not been fully perceived. 2 According to what was mentioned above and since numerous studies have emphasized the destructive impact of H. pylori on human health, the current study discussed the association and mechanism of H. pylori inflammation and its role in GC.…”

Section: Introductionmentioning

confidence: 88%

“…1 Gastric cancer (GC) is the second major cause of mortality across the world. 2 The most common form of GC is adenocarcinoma, originating from the innermost layer of the gastric wall or mucosal layer. The second most frequent cause of cancer mortality around the world is gastric adenocarcinoma, and infection with the bacterial pathogen Helicobacter pylori is the most substantial recognized risk factor for this malignancy.…”

Section: Introductionmentioning

confidence: 99%

The Role of Cytokines and Pattern Recognition Receptors in Inflammation Caused by Helicobacter pylori Infection in Gastric Cancer

Ganjali

Fakheri

Bahari

et al. 2022

Int J Basic Sci Med

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One of the most common and most critical mortality causes in modern society is gastrointestinal (GI) cancer. Helicobacter pylori is one of the most potent risk factors of gastric cancer. This bacterium can suppress the immune system by various pathogenic factors and mechanisms, lead to chronic inflammatory responses, and play a critical role in the induction of cancer. The first part of this article begins with a description of H. pylori carcinogenicity and in the next part, the roles of innate immunity pattern recognition receptors (PRRs), Toll-like receptors (TLRs), cytokines, and inflammatory regulatory mechanisms in H. pylori infection are discussed. According to our current knowledge, screening and on-time diagnosis of the disease, timely treatment, and immediate eradication of H. pylori are the most critical ways to barricade gastric cancer progression. In the end, it is suggested that, considering the expensive costs of gastric cancer treatment, H. pylori diagnostic screening tests be done at least annually in middle-aged and at-risk people.

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“…This was based on the estimated occurrence of 1 million cases worldwide [ 3 ]. As a result of the late detection of the disease at a more advanced stage, the mortality rate of gastric cancer is significant; for example, in 2020, it was 768,793, which places it as the fifth most prevalent cause of death due to cancer [ 4 , 5 ]. Despite the fact that surgery is the primary treatment with the intention of curing the disease, 40%–60% of those patients who undergo resection surgery show disease relapse [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Molecular Analyses of Notch Pathway-Related Genes to Predict Prognosis and Immunotherapy Response in Patients with Gastric Cancer

Song

Gao

Yang

et al. 2023

Journal of Oncology

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Gastric cancer (GC) is a highly molecular heterogeneous tumor with unfavorable outcomes. The Notch signaling pathway is an important regulator of immune cell differentiation and has been associated with autoimmune disorders, the development of tumors, and immunomodulation caused by tumors. In this study, by developing a gene signature based on genes relevant to the Notch pathway, we could improve our ability to predict the outcome of patients with GC. From the TCGA database, RNA sequencing data of GC tumors and associated normal tissues were obtained. Microarray data were collected from GEO datasets. The Molecular Signature Database (MSigDB) was accessed in order to retrieve sets of human Notch pathway-related genes (NPRGs). The LASSO analysis performed on the TCGA cohort was used to generate a multigene signature based on prognostic NPRGs. In order to validate the gene signature, the GEO cohort was utilized. Using the CIBERSORT method, we were able to determine the amounts of immune cell infiltration in the GC. In this study, a total of 21 differentially expressed NPRGs were obtained between GC specimens and nontumor specimens. The construction of a prognostic prediction model for patients with GC involved the identification and selection of three different NPRGs. According to the appropriate cutoff value, the patients with GC were divided into two groups: those with a low risk and those with a high risk. The time-dependent ROC curves demonstrated that the new model had satisfactory performance when it came to prognostic prediction. Multivariate assays confirmed that the risk score was an independent marker that may be used to predict the outcome of GC. In addition, the generated nomogram demonstrated a high level of predictive usefulness. Moreover, the scores of immunological infiltration of the majority of immune cells were distinctly different between the two groups, and the low-risk group responded to immunotherapy in a significantly greater degree. According to the results of a functional enrichment study of candidate genes, there are multiple pathways and processes associated with cancer. Taken together, a new gene model associated with the Notch pathway may be utilized for the purpose of predicting the prognosis of GC. One potential method of treatment for GC is to focus on NPRGs.

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Review: Gastric cancer: Basic aspects

Cited by 5 publications

References 33 publications

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

Overexpression of heat shock protein 47 is associated with increased proliferation and metastasis in gastric cancer

The Role of Cytokines and Pattern Recognition Receptors in Inflammation Caused by Helicobacter pylori Infection in Gastric Cancer

Comprehensive Molecular Analyses of Notch Pathway-Related Genes to Predict Prognosis and Immunotherapy Response in Patients with Gastric Cancer

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